Tyw1 tRNA-yW synthesizing protein 1 homolog [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Tyw1provided by RGD
Full Name: tRNA-yW synthesizing protein 1 homologprovided by RGD
Primary source: RGD:1310420
See related: Ensembl:ENSRNOG00000024352 AllianceGenome:RGD:1310420
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rsafd1; RGD1310420
Summary: Predicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; FMN binding activity; and tRNA-4-demethylwyosine synthase activity. Predicted to be involved in wybutosine biosynthetic process. Predicted to be integral component of membrane. Orthologous to several human genes including TYW1 (tRNA-yW synthesizing protein 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 173.9), Kidney (RPKM 157.1) and 9 other tissues See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12q12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (31968198..32054454, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (26332020..26418286, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (29824990..29919240, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH143463 (e-PCR)
- UniSTS:232710

AU046764 (e-PCR)
- UniSTS:111153

D12Got63 (e-PCR)
- UniSTS:115345

RH133721 (e-PCR)
- UniSTS:217004

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables FMN binding	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in wybutosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: tRNA wybutosine-synthesizing protein 1 homolog

Names: S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase-like; radical S-adenosyl methionine and flavodoxin domains 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107137.1 → NP_001100607.1 tRNA wybutosine-synthesizing protein 1 homolog

See identical proteins and their annotated locations for NP_001100607.1

Status: PROVISIONAL

Source sequence(s)

CH473973

UniProtKB/TrEMBL

A0A8I6AB63, A6J0M1, B5DF48, F7FB90

Related

ENSRNOP00000038092.4, ENSRNOT00000038092.6

Conserved Domains (4) summary

cd01335
Location:404 → 596

Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...

PRK13762
Location:342 → 654

PRK13762; tRNA-modifying enzyme; Provisional

pfam00258
Location:76 → 227

Flavodoxin_1; Flavodoxin

pfam08608
Location:586 → 649

Wyosine_form; Wyosine base formation