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    Rad51d RAD51 paralog D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303375, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rad51dprovided by RGD
    Official Full Name
    RAD51 paralog Dprovided by RGD
    Primary source
    RGD:1306944
    See related
    Ensembl:ENSRNOG00000007596 AllianceGenome:RGD:1306944
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rad51l3
    Summary
    Predicted to enable ATP-dependent activity, acting on DNA; gamma-tubulin binding activity; and single-stranded DNA binding activity. Predicted to contribute to four-way junction DNA binding activity. Predicted to be involved in DNA recombination. Predicted to act upstream of or within DNA repair; chromosome organization; and regulation of cell cycle. Predicted to be located in chromosome, telomeric region; cytoplasm; and nucleus. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Predicted to be active in centrosome and replication fork. Human ortholog(s) of this gene implicated in hereditary breast ovarian cancer syndrome. Orthologous to human RAD51D (RAD51 paralog D). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 112.0), Kidney (RPKM 81.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q26
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (68303350..68322002, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (67805720..67824452, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70222703..70241352, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547954 Neighboring gene DNA ligase 3 Neighboring gene ring finger and FYVE-like domain containing E3 ubiquitin protein ligase Neighboring gene U6 spliceosomal RNA Neighboring gene fibronectin type III domain containing 8 Neighboring gene notchless homolog 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Extensive chromosomal instability in Rad51d-deficient mouse cells. Smiraldo PG, et al. Cancer Res, 2005 Mar 15. PMID 15781618
    2. The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2. Braybrooke JP, et al. J Biol Chem, 2000 Sep 15. PMID 10871607
    3. Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex. Kurumizaka H, et al. J Biol Chem, 2002 Apr 19. PMID 11834724
    4. The splicing-factor related protein SFPQ/PSF interacts with RAD51D and is necessary for homology-directed repair and sister chromatid cohesion. Rajesh C, et al. Nucleic Acids Res, 2011 Jan. PMID 20813759, Free PMC Article
    5. Homologous recombination proteins are associated with centrosomes and are required for mitotic stability. Cappelli E, et al. Exp Cell Res, 2011 May 1. PMID 21276791

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP-dependent activity, acting on DNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to four-way junction DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA strand invasion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA strand invasion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within chromosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance via recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Rad51B-Rad51C-Rad51D-XRCC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rad51B-Rad51C-Rad51D-XRCC2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair protein RAD51 homolog 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107029.2 → NP_001100499.1  DNA repair protein RAD51 homolog 4

      See identical proteins and their annotated locations for NP_001100499.1

      Status: PROVISIONAL

      Source sequence(s)
      BC169062
      UniProtKB/TrEMBL
      A0A8I5ZUK5, A6HHE8, A6HHF0, B5DFH5, F7ET37
      Related
      ENSRNOP00000036257.3, ENSRNOT00000038376.6
      Conserved Domains (2) summary
      PRK09302
      Location:61 → 114
      PRK09302; circadian clock protein KaiC; Reviewed
      cd19489
      Location:94 → 299
      Rad51D; RAD51D recombinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      68303350..68322002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597307.3 → XP_017452796.1  DNA repair protein RAD51 homolog 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKB7, A0A8L2Q4J8
      Related
      ENSRNOP00000093509.1

    2. XM_063269087.1 → XP_063125157.1  DNA repair protein RAD51 homolog 4 isoform X3

    3. XM_063269086.1 → XP_063125156.1  DNA repair protein RAD51 homolog 4 isoform X1

    4. XM_006246997.5 → XP_006247059.1  DNA repair protein RAD51 homolog 4 isoform X4

      See identical proteins and their annotated locations for XP_006247059.1

      UniProtKB/TrEMBL
      A0A8I5ZUK5, A0A8I6AMP7, A6HHE8, A6HHE9
      Related
      ENSRNOP00000096856.1
      Conserved Domains (2) summary
      cl21455
      Location:82 → 264
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl23768
      Location:13 → 85
      ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    Nucleotide Protein Strain
    Heading Accession and Version

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