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    Cul4b cullin 4B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302502, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cul4bprovided by RGD
    Official Full Name
    cullin 4Bprovided by RGD
    Primary source
    RGD:1564494
    See related
    Ensembl:ENSRNOG00000002585 AllianceGenome:RGD:1564494
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564494
    Summary
    Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Predicted to contribute to damaged DNA binding activity. Involved in neuron projection development. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Orthologous to human CUL4B (cullin 4B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 139.8), Thymus (RPKM 133.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cul4b in Genome Data Viewer
    Location:
    Xq35
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (122154332..122192299, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (117287481..117326688, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (124831391..124870329, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene lysosomal-associated membrane protein 2 Neighboring gene ragulator complex protein LAMTOR5-like Neighboring gene uncharacterized LOC134484034 Neighboring gene MCTS1, re-initiation and release factor Neighboring gene C1GALT1-specific chaperone 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CUL4B promotes the pathology of adjuvant-induced arthritis in rats through the canonical Wnt signaling. Miao C, et al. J Mol Med (Berl), 2018 Jun. PMID 29626254
    2. MiR-674-5p Suppresses the Proliferation and Migration of Glioma Cells by Targeting Cul4b. Li W, et al. Neurochem Res, 2022 Mar. PMID 34779995
    3. Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage. Dooley S, et al. Gastroenterology, 2008 Aug. PMID 18602923
    4. X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression. Nakagawa T, et al. Mol Cell, 2011 Aug 5. PMID 21816345, Free PMC Article
    5. The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels. Chen YA, et al. Sci Rep, 2015 May 29. PMID 26021757, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circ_0011058 alleviates RA pathology through the circ_0011058/miR-335-5p/CUL4B signal axis.
      Title: Circ_0011058 alleviates RA pathology through the circ_0011058/miR-335-5p/CUL4B signal axis.
    2. MiR-674-5p Suppresses the Proliferation and Migration of Glioma Cells by Targeting Cul4b.
      Title: MiR-674-5p Suppresses the Proliferation and Migration of Glioma Cells by Targeting Cul4b.
    3. CUL4B expression is up-regulated in synovium and FLS from adjuvant-induced arthritis (AIA) rats. Increased CUL4B promotes the canonical Wnt signaling and promotes the pathogenesis of AIA rats. Decreased miR-101-3p contributes to disordered CUL4B.
      Title: CUL4B promotes the pathology of adjuvant-induced arthritis in rats through the canonical Wnt signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UV-damage excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul4A-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul4B-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul4B-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cullin-4B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106951.1 → NP_001100421.1  cullin-4B

      See identical proteins and their annotated locations for NP_001100421.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473991
      UniProtKB/TrEMBL
      A0A8I6B5A8, A6JMK5, D3ZK73
      Related
      ENSRNOP00000060639.1, ENSRNOT00000065023.3
      Conserved Domains (3) summary
      smart00182
      Location:654 → 794
      CULLIN; Cullin
      smart00884
      Location:900 → 965
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:276 → 871
      Cullin; Cullin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      122154332..122192299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257489.5 → XP_006257551.1  cullin-4B isoform X1

      UniProtKB/TrEMBL
      A0A8I6B5A8
      Conserved Domains (3) summary
      smart00182
      Location:592 → 732
      CULLIN; Cullin
      smart00884
      Location:838 → 903
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:214 → 809
      Cullin; Cullin family

    2. XM_039099624.2 → XP_038955552.1  cullin-4B isoform X2

      UniProtKB/TrEMBL
      A0A8I6B5A8
      Related
      ENSRNOP00000097090.1
      Conserved Domains (2) summary
      smart00884
      Location:711 → 776
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:86 → 683
      Cullin; Cullin family
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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