Ebag9 estrogen receptor binding site associated antigen 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ebag9provided by RGD
Official Full Name: estrogen receptor binding site associated antigen 9provided by RGD
Primary source: RGD:1307293
See related: Ensembl:ENSRNOG00000004220 AllianceGenome:RGD:1307293
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in apoptotic process. Located in secretory granule. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human EBAG9 (estrogen receptor binding site associated antigen 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 64.3), Spleen (RPKM 53.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q31

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (77695213..77713565)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (75810950..75828902)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (83564563..83582516)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBAG9 and Snapin have roles in controlling exocytosis processes
Title: EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin.

Submit: New GeneRIF Correction

General gene information

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Markers

RH137875 (e-PCR)
- UniSTS:219962

Ebag9 (e-PCR), detects polymorphism
- UniSTS:532422

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune memory response involving T cells and B cells	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adaptive immune memory response involving T cells and B cells	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: receptor-binding cancer antigen expressed on SiSo cells

Names: estrogen receptor-binding fragment-associated gene 9 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009665.1 → NP_001009665.1 receptor-binding cancer antigen expressed on SiSo cells

See identical proteins and their annotated locations for NP_001009665.1

Status: PROVISIONAL

Source sequence(s)

BC087093

UniProtKB/Swiss-Prot

Q5PQP2

UniProtKB/TrEMBL

A0A8I6AKF8, A6HRB8

Related

ENSRNOP00000093345.1, ENSRNOT00000105068.1

Conserved Domains (1) summary

pfam07946
Location:160 → 203

DUF1682; Protein of unknown function (DUF1682)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

77695213..77713565

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263241.1 → XP_063119311.1 receptor-binding cancer antigen expressed on SiSo cells isoform X1

UniProtKB/TrEMBL

A0A8L2Q2E3
XM_063263242.1 → XP_063119312.1 receptor-binding cancer antigen expressed on SiSo cells isoform X2

UniProtKB/Swiss-Prot

Q5PQP2

UniProtKB/TrEMBL

A6HRB8