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    Galnt7 polypeptide N-acetylgalactosaminyltransferase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29750, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Galnt7provided by RGD
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 7provided by RGD
    Primary source
    RGD:620362
    See related
    Ensembl:ENSRNOG00000012037 AllianceGenome:RGD:620362
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to act upstream of or within protein O-linked glycosylation. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Orthologous to human GALNT7 (polypeptide N-acetylgalactosaminyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 109.7), Spleen (RPKM 63.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    16p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (37589368..37713911)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (32578643..32703189)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (35935059..36062734)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase-like 6 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134482370 Neighboring gene uncharacterized LOC120097422 Neighboring gene uncharacterized LOC120097421 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene high mobility group box 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of a UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase that displays glycopeptide N-acetylgalactosaminyltransferase activity. Ten Hagen KG, et al. J Biol Chem, 1999 Sep 24. PMID 10488133
    2. Cloning and characterization of a ninth member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, ppGaNTase-T9. Ten Hagen KG, et al. J Biol Chem, 2001 May 18. PMID 11278534
    3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylgalactosaminyltransferase 7
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
    galNAc-T7
    polypeptide GalNAc transferase 7
    pp-GaNTase 7
    protein-UDP acetylgalactosaminyltransferase 7
    NP_075215.1
    XP_006253145.1
    XP_038950365.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022926.2 → NP_075215.1  N-acetylgalactosaminyltransferase 7

      See identical proteins and their annotated locations for NP_075215.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q9R0C5
      UniProtKB/TrEMBL
      A0A8L2R704, A6KIU5
      Related
      ENSRNOP00000072171.2, ENSRNOT00000084707.2
      Conserved Domains (4) summary
      cd02510
      Location:210 → 518
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:210 → 331
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:535 → 651
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:534 → 649
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      37589368..37713911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253083.4 → XP_006253145.1  N-acetylgalactosaminyltransferase 7 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q857, A0A8L2R704
      Related
      ENSRNOP00000016474.3
      Conserved Domains (4) summary
      cd02510
      Location:210 → 518
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG1215
      Location:210 → 438
      BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]
      cd00161
      Location:535 → 651
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:534 → 649
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. XM_039094437.2 → XP_038950365.1  N-acetylgalactosaminyltransferase 7 isoform X2

      Conserved Domains (2) summary
      cd02510
      Location:1 → 295
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:311 → 426
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0C5.1 GenPept UniProtKB/Swiss-Prot:Q9R0C5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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