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    Cst7 cystatin F [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296257, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cst7provided by RGD
    Official Full Name
    cystatin Fprovided by RGD
    Primary source
    RGD:1309154
    See related
    Ensembl:ENSRNOG00000006767 AllianceGenome:RGD:1309154
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity and protein homodimerization activity. Predicted to be involved in inhibition of cysteine-type endopeptidase activity; negative regulation of microglial cell activation; and positive regulation of myelination. Predicted to be located in multivesicular body. Predicted to be active in several cellular components, including Golgi apparatus; late endosome; and lysosome. Orthologous to human CST7 (cystatin F). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 42.5), Kidney (RPKM 41.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3q41
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (159857221..159865987)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (139396830..139405557)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (146363913..146373365)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene galactokinase 1 like 1 Neighboring gene galactokinase 1, pseudogene 4 Neighboring gene ribosomal protein SA, pseudogene 6 Neighboring gene adipocyte plasma membrane associated protein Neighboring gene acyl-CoA synthetase short-chain family member 1 Neighboring gene uncharacterized LOC102547396

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibitory properties of cystatin F and its localization in U937 promonocyte cells. Langerholc T, et al. FEBS J, 2005 Mar. PMID 15752368
    2. Regulated expression and intracellular localization of cystatin F in human U937 cells. Nathanson CM, et al. Eur J Biochem, 2002 Nov. PMID 12423348
    3. Cystatin F is a biomarker of prion pathogenesis in mice. Nuvolone M, et al. PLoS One, 2017. PMID 28178353, Free PMC Article
    4. Cystatin F is secreted, but artificial modification of its C-terminus can induce its endocytic targeting. Cappello F, et al. Exp Cell Res, 2004 Jul 15. PMID 15212960
    5. Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis. Hamilton G, et al. EMBO J, 2008 Feb 6. PMID 18256700, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inhibition of cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of microglial cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of myelination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in multivesicular body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cystatin-F
    Names
    cystatin F (leukocystatin)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106523.1 → NP_001099993.1  cystatin-F precursor

      See identical proteins and their annotated locations for NP_001099993.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474050
      UniProtKB/TrEMBL
      A6KHF1, A6KHF2, D3ZCV2
      Related
      ENSRNOP00000008865.4, ENSRNOT00000008865.5
      Conserved Domains (1) summary
      smart00043
      Location:39 → 148
      CY; Cystatin-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      159857221..159865987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235213.5 → XP_006235275.1  cystatin-F isoform X2

      Conserved Domains (1) summary
      smart00043
      Location:71 → 180
      CY; Cystatin-like domain

    2. XM_039104598.2 → XP_038960526.1  cystatin-F isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADY1
      Related
      ENSRNOP00000092435.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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