Alox5ap arachidonate 5-lipoxygenase activating protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Alox5approvided by RGD
Official Full Name: arachidonate 5-lipoxygenase activating proteinprovided by RGD
Primary source: RGD:2097
See related: Ensembl:ENSRNOG00000000907 AllianceGenome:RGD:2097
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables enzyme binding activity and identical protein binding activity. Contributes to arachidonate 5-lipoxygenase activity. Involved in leukotriene biosynthetic process; lipoxygenase pathway; and positive regulation of acute inflammatory response. Located in cytosol; endoplasmic reticulum; and nuclear envelope. Used to study pulmonary hypertension. Biomarker of glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including asthma; brain infarction (multiple); breast cancer; cerebral palsy; and coronary artery disease (multiple). Orthologous to human ALOX5AP (arachidonate 5-lipoxygenase activating protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 111.6), Spleen (RPKM 67.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (10785254..10809295, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (5748941..5772986, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (6854930..6879112, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bexarotene Exerts Protective Effects Through Modulation of the Cerebral Vascular Smooth Muscle Cell Phenotypic Transformation by Regulating PPARgamma/FLAP/LTB4 After Subarachnoid Hemorrhage in Rats.
Title: Bexarotene Exerts Protective Effects Through Modulation of the Cerebral Vascular Smooth Muscle Cell Phenotypic Transformation by Regulating PPARγ/FLAP/LTB(4) After Subarachnoid Hemorrhage in Rats.
The time-dependent reorganization has been reported of both 5-LO and FLAP into higher-order assemblies or clusters in the process of leukotriene C4 biosynthesis on the nuclear envelope in response to cell activation via the IgE receptor.
Title: The organization of leukotriene biosynthesis on the nuclear envelope revealed by single molecule localization microscopy and computational analyses.
Study results suggest that the association of ALOX5/ALOX5AP contributes to leukotriene-induced inflammation and predisposes the trauma and hemorrhagic shock rats to lung injury.
Title: Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue.
BRP-7 potently suppresses leukotriene biosynthesis by interacting with FLAP in rat pleurisy model
Title: The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP).
To evaluate whether mRNA levels of Pde4d and Alox5ap were associated with hypertensive stroke and hypertension in stroke-prone renovascular hypertensive rats (RHRSP) which could simulate human being's hypertensive cerebral stroke.
Title: [Association between mRNA level of Pde4d and Alox5ap and hypertensive stroke as well as hypertension in rats].
hyperoxia increases LTB(4) output, as well as protein levels of 5-LO and FLAP, in newborn rat lungs during early postnatal life.
Title: Hyperoxia increases protein mass of 5-lipoxygenase and its activating protein, flap, and leukotriene B(4) output in newborn rat lungs.
This protein is expressed in peritoneal macrophages during ovalbumin-induced immediate cutaneous hypersensitivity reactions.
Title: Increased expression of cytosolic phospholipase A2, 5-lipoxygenase and 5-lipoxygenase-activating protein in rat peritoneal macrophages during ovalbumin-induced sensitization.

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General gene information

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Markers

Alox5ap (e-PCR), detects polymorphism
- UniSTS:526779

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to arachidonate 5-lipoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonic acid binding	ISO Inferred from Sequence Orthology more info
enables arachidonic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme activator activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables glutathione peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables leukotriene-C4 synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in leukotriene biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukotriene biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within leukotriene biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in leukotriene biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukotriene production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in lipoxygenase pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in lipoxygenase pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of acute inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: arachidonate 5-lipoxygenase-activating protein

Names: 5-lipoxygenase-activating protein FLAP; FLAP; MK-886-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.