Tnni3k TNNI3 interacting kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnni3kprovided by RGD
Official Full Name: TNNI3 interacting kinaseprovided by RGD
Primary source: RGD:727908
See related: Ensembl:ENSRNOG00000028225 AllianceGenome:RGD:727908
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cark
Summary: Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; protein C-terminus binding activity; and troponin I binding activity. Predicted to be involved in protein phosphorylation; regulation of heart contraction; and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to several human genes including FPGT-TNNI3K (FPGT-TNNI3K readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 662.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q45

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (246397051..246665000, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (243737346..244005319, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (261069210..261337294, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TNNI3K may be a novel mediator of cardiac troponin I phosphorylation and contribute to the regulation of cardiac myofilament contraction function.
Title: TNNI3K is a novel mediator of myofilament function and phosphorylates cardiac troponin I.
TNNI3K promotes a concentric hypertrophy with enhancement of cardiac function via regulating the phosphorylation of cTnI
Title: TNNI3K, a cardiac-specific kinase, promotes physiological cardiac hypertrophy in transgenic mice.

Submit: New GeneRIF Correction

General gene information

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Markers

AU025675 (e-PCR)
- UniSTS:115030

AU048026 (e-PCR)
- UniSTS:109946

RH128803 (e-PCR)
- UniSTS:212111

BE100289 (e-PCR)
- UniSTS:249797

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bundle of His cell to Purkinje myocyte communication	IEA Inferred from Electronic Annotation more info
involved_in bundle of His cell to Purkinje myocyte communication	ISO Inferred from Sequence Orthology more info
involved_in bundle of His cell to Purkinje myocyte communication	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cardiac conduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac conduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of heart rate	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine/threonine-protein kinase TNNI3K

Names: cardiac ankyrin repeat kinase

NP_861434.1

EC 2.7.11.1

XP_038958039.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181769.1 → NP_861434.1 serine/threonine-protein kinase TNNI3K

See identical proteins and their annotated locations for NP_861434.1

Status: PROVISIONAL

Source sequence(s)

AY303692

UniProtKB/Swiss-Prot

Q7TQP6

UniProtKB/TrEMBL

F1LPM9

Related

ENSRNOP00000031479.5, ENSRNOT00000030341.7

Conserved Domains (6) summary

smart00219
Location:463 → 719

TyrKc; Tyrosine kinase, catalytic domain

cd00204
Location:99 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14064
Location:469 → 722

PKc_TNNI3K; Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase

pfam12796
Location:138 → 232

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:340 → 401

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:134 → 164

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

246397051..246665000 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102111.2 → XP_038958039.1 serine/threonine-protein kinase TNNI3K isoform X1

UniProtKB/TrEMBL

F1LPM9

Conserved Domains (4) summary

PHA03095
Location:120 → 414

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:134 → 164

ANK; ANK repeat [structural motif]

pfam12796
Location:71 → 164

Ank_2; Ankyrin repeats (3 copies)

cl21453
Location:469 → 670

PKc_like; Protein Kinases, catalytic domain