Adora1 adenosine A1 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

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Official Symbol: Adora1provided by RGD
Official Full Name: adenosine A1 receptorprovided by RGD
Primary source: RGD:2048
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary: inhibits adenylyl cyclase activity; plays a role in regulation of arterial pressure, heart rate, and sodium excretion [RGD, Feb 2006]

Genomic context

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Location :: 13q13

Sequence :: Chromosome: 13; NC_005112.3 (56099178..56131141, complement)

See Adora1 in MapViewer

Chromosome 13 - NC_005112.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

N6-cyclopentyladenosine, an adenosine A1 receptor agonist dose-dependently inhibited cardiomyocyte protein synthesis and hypertrophy induced by TNF-alpha.
Title: Activation of adenosine A1 receptor attenuates tumor necrosis factor-α induced hypertrophy of cardiomyocytes.
Extracellular ATP reduces epileptiform activity via activation of adenosine A1 receptors.
Title: Extracellular ATP differentially affects epileptiform activity via purinergic P2X7 and adenosine A1 receptors in naive and chronic epileptic rats.
The present study was designed to determine whether and how adenosine receptor activation induces translocation of PKCepsilon to mitochondria.
Title: Molecular mechanism underlying adenosine receptor-mediated mitochondrial targeting of protein kinase C.
[review] Activation of both Adora1 and Adora3 receptors prior to ischemia has been shown in multiple experimental models to reduce ischemia/reperfusion-induced cardiac injury.
Title: Adenosine receptor-mediated cardioprotection: are all 4 subtypes required or redundant?
Data suggest that expression of Adora1 is too low to play a major role in regulation of lipogenic gene expression in hepatocytes; studies include investigation of gene expression under influence of Adora1 agonists.
Title: Adenosine A₁ receptors do not play a major role in the regulation of lipogenic gene expression in hepatocytes.
Adenosine A1 receptor density is not changed between exercise groups of adult and middle aged rats, but treadmill running counteracted the age-related increase in adenosine A2A receptor densities.
Title: Treadmill running frequency on anxiety and hippocampal adenosine receptors density in adult and middle-aged rats.
Activation of adenosine A receptors could contribute to antidepressant effects.
Title: Activation of adenosine₁ receptors induces antidepressant-like, anti-impulsive effects on differential reinforcement of low-rate 72-s behavior in rats.
Adenosine A1 receptors are possibly involved in the modulation of rhythmical respiration through the inhibitory synaptic input from inspiration-related neurons.
Title: Adenosine A1 receptors are involved in the modulation of the rhythmical respiration in neonatal rat brainstem slice in vitro.
Presynaptic adenosine A receptors decrease action potential-dependent glutamate release from trigeminal primary afferents onto medullary dorsal horn neurons and could be a potential target for the treatment of pain in orofacial tissues.
Title: A₁ receptors inhibit glutamate release in rat medullary dorsal horn neurons.
Adenosine modulates the excitability of layer II stellate neurons in entorhinal cortex through A1 receptors. Adenosine-induced inhibition was blocked by DPCPX,a selective A1 receptor antagonist, but not by DMPX, a selective A2 receptor antagonist.
Title: Adenosine modulates the excitability of layer II stellate neurons in entorhinal cortex through A1 receptors.

Submit: New GeneRIF Correction See all (96)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:247960	BioGRID:259422	Epb41l2		BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid

Pathways from BioSystems

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Adenosine P1 receptors, organism-specific biosystem (from REACTOME)
Adenosine P1 receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
GPCRs, Class A Rhodopsin-like, organism-specific biosystem
GPCRs, Class A Rhodopsin-like
Morphine addiction, organism-specific biosystem (from KEGG)
Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
Morphine addiction, conserved biosystem (from KEGG)
Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
Neuroactive ligand-receptor interaction, organism-specific biosystem
Neuroactive ligand-receptor interaction
Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
Neuroactive ligand-receptor interaction, conserved biosystem
Neuroactive ligand-receptor interaction
Nucleotide GPCRs, organism-specific biosystem (from WikiPathways)
Nucleotide GPCRs, organism-specific biosystem
Nucleotide GPCRs
Nucleotide-like (purinergic) receptors, organism-specific biosystem (from REACTOME)
Nucleotide-like (purinergic) receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

D13Hmgc03 (e-PCR)
- UniSTS:518941

BB176431 (e-PCR)
- UniSTS:185452

Adora1 (e-PCR), detects polymorphism
- UniSTS:256460

UniSTS:141040 (e-PCR)
- UniSTS:141040

Adora1 (e-PCR), detects polymorphism
- UniSTS:141040

Homology

Homologs of the Adora1 gene: The Adora1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, and zebrafish.
Map Viewer (Human, Mouse)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
G-protein beta/gamma-subunit complex binding	IDA Inferred from Direct Assay more info	PubMed
G-protein coupled adenosine receptor activity	IDA Inferred from Direct Assay more info	PubMed
G-protein coupled adenosine receptor activity	TAS Traceable Author Statement more info	PubMed
G-protein coupled receptor binding	IPI Inferred from Physical Interaction more info	PubMed
heterotrimeric G-protein binding	IDA Inferred from Direct Assay more info	PubMed
phospholipase C activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
purine nucleoside binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
activation of MAPKK activity	IDA Inferred from Direct Assay more info	PubMed
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
cognition	IMP Inferred from Mutant Phenotype more info	PubMed
detection of temperature stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info
lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of acute inflammatory response	IDA Inferred from Direct Assay more info	PubMed
negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of circadian sleep/wake cycle, non-REM sleep	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of circadian sleep/wake cycle, sleep	IDA Inferred from Direct Assay more info	PubMed
negative regulation of glutamate secretion	IDA Inferred from Direct Assay more info	PubMed
negative regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
negative regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info
negative regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
negative regulation of lipid catabolic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of mucus secretion	IEA Inferred from Electronic Annotation more info
negative regulation of mucus secretion	ISO Inferred from Sequence Orthology more info
negative regulation of neurotrophin production	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of renal sodium excretion	IMP Inferred from Mutant Phenotype more info	PubMed
Not negative regulation of synaptic transmission, GABAergic	IDA Inferred from Direct Assay more info	PubMed
negative regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of synaptic transmission, glutamatergic	IDA Inferred from Direct Assay more info	PubMed
negative regulation of vasodilation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
positive regulation of epidermal growth factor-activated receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of nucleoside transport	IDA Inferred from Direct Assay more info	PubMed
positive regulation of peptide secretion	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info
regulation of excitatory postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of excitatory postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
regulation of glomerular filtration	IEA Inferred from Electronic Annotation more info
regulation of glomerular filtration	ISO Inferred from Sequence Orthology more info
regulation of respiratory gaseous exchange by neurological system process	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
Not regulation of vasodilation	IDA Inferred from Direct Assay more info	PubMed
relaxation of vascular smooth muscle	IMP Inferred from Mutant Phenotype more info	PubMed
response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
asymmetric synapse	IDA Inferred from Direct Assay more info	PubMed
axolemma	IDA Inferred from Direct Assay more info	PubMed
basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
cell body	IDA Inferred from Direct Assay more info	PubMed
dendrite	IDA Inferred from Direct Assay more info	PubMed
endomembrane system	IDA Inferred from Direct Assay more info	PubMed
endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adenosine receptor A1

Names: adenosine receptor A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017155.2 → NP_058851.2 adenosine receptor A1

Status: PROVISIONAL

Source sequence(s)

M69045

UniProtKB/Swiss-Prot

P25099

Conserved Domains (2) summary

pfam00001
Location:32 – 288
Blast Score: 248

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:20 – 122
Blast Score: 94

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Build 5.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

NC_005112.3 Reference Rnor_5.0 Primary Assembly

Range

56099178..56131141, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

AC_000081.1 Alternate Rn_Celera

Range

45990556..46022753, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AABR06074758.1 (17378..38551)	None
genomic	AABR06074759.1	None
genomic	AAHX01075168.1 (20088..41291)	None
genomic	AAHX01075169.1	None
genomic	CH473958.2	EDM09736.1
		EDM09737.1
mRNA	AB001089.1	BAA19231.1
mRNA	AF042079.1	AAC03772.1	W
mRNA	M69045.1	AAB07231.1
mRNA	Y12519.1	CAA73119.1	W