CD274 CD274 molecule [Homo sapiens (human)] - Gene

Summary

Go to the top of the page Help

Official Symbol: CD274provided by HGNC
Official Full Name: CD274 moleculeprovided by HGNC
Primary source: HGNC:17635
See related: Ensembl:ENSG00000120217; HPRD:05655; MIM:605402; Vega:OTTHUMG00000019503
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1

Genomic context

Go to the top of the page Help

Location :: 9p24

Sequence :: Chromosome: 9; NC_000009.11 (5450503..5470567)

See CD274 in Epigenomics, MapViewer

Chromosome 9 - NC_000009.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that the immunomodulatory proteins B7-H1, B7-H3, and HLA-G5 are secreted from early and term placenta via exosomes and have important implications in mechanisms by which trophoblast immunomodulators modify maternal immunological milieu.
Title: Immunomodulatory molecules are released from the first trimester and term placenta via exosomes.
PD-L1 expression in monocytes is regulated by opposing actions of TNF-alpha and TGF-beta. As PD-L1 functions to fine tune lymphocyte activation, dysregulation of cytokines resulting in reduced expression could lead to loss of peripheral T cell tolerance
Title: TNF-α and TGF-β counter-regulate PD-L1 expression on monocytes in systemic lupus erythematosus.
High B7-H1 expression is associated with multiple myeloma.
Title: Marrow stromal cells induce B7-H1 expression on myeloma cells, generating aggressive characteristics in multiple myeloma.
B7h stimulation modulates dendritic cell function with effects on their maturation and recruitment into tissues.
Title: Triggering of B7h by the ICOS modulates maturation and migration of monocyte-derived dendritic cells.
The levels of PD-1 and PD-L1 expression were significantly up-regulated in the inflammation ascending phase, initial and climax period and in parallel with hepatitis B virus-specific clonal expansion.
Title: Longitudinal fluctuations in PD1 and PD-L1 expression in association with changes in anti-viral immune response in chronic hepatitis B.
Human cardiac progenitor cells in allogeneic settings have a PD-L1-dependent tolerogenic immune behavior.
Title: Allogenicity of human cardiac stem/progenitor cells orchestrated by programmed death ligand 1.
PD-L1 is highly expressed in various kinds of lymphomas, either in tumor tissues or lymphoma cell lines.
Title: Contribution of PD-L1 to oncogenesis of lymphoma and its RNAi-based targeting therapy.
PD-1/B7-H1 pathway may play an important role in negatively modulating T cell-mediated immune response in oral lichen planus, and provide the rationale to employ B7-H1 expression on peripheral blood T cells as a marker of severity of Oral lichen planus
Title: Increased B7-H1 expression on peripheral blood T cells in oral lichen planus correlated with disease severity.
HBsAg regulate immune response by tipping the balance between B7-H1 and CD40
Title: Study of human B7 homolog 1 expression in patients with hepatitis B virus infection.
Induction of the B7-H1/PD-1 pathway may represent an adaptive immune resistance mechanism exerted by tumor cells.
Title: Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape.

Submit: New GeneRIF Correction See all (181)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

Go to the top of the page Help

Protein	Gene	Interaction	Pubs
Tat, p14	tat	HIV-1 Tat-induced upregulation of B7-H1 protein expression requires activation of the ERK/MAPK signaling pathway in human endothelial cells	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Source	Pubs	Description
NP_054862.1	NP_005009.1	PDCD1	BIND	PubMed	PD-1 interacts with B7-H1.
Q9NZQ7	Q15116	PDCD1	HPRD	PubMed
BioGRID:118891	BioGRID:111745	PTPN11	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

Go to the top of the page Help

Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
PD-1 signaling, organism-specific biosystem (from REACTOME)
PD-1 signaling, organism-specific biosystemThe Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation ...

General gene information

Go to the top of the page Help

Markers

RH92039 (e-PCR)
- UniSTS:89611

RH78877 (e-PCR)
- UniSTS:19525

PDCD1LG1_2379 (e-PCR)
- UniSTS:280902

SHGC-83529 (e-PCR)
- UniSTS:101741

NoName (e-PCR)
- UniSTS:481934

RH45176 (e-PCR)
- UniSTS:1448

NoName (e-PCR)
- UniSTS:481761

NoName (e-PCR)
- UniSTS:486119

Homology

Homologs of the CD274 gene: The CD274 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
T cell costimulation	IDA Inferred from Direct Assay more info	PubMed
T cell costimulation	TAS Traceable Author Statement more info
cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
immune response	IDA Inferred from Direct Assay more info	PubMed
negative regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of T cell proliferation	TAS Traceable Author Statement more info	PubMed
positive regulation of interleukin-10 secretion	IDA Inferred from Direct Assay more info	PubMed
signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
endomembrane system	IEA Inferred from Electronic Annotation more info
external side of plasma membrane	IEA Inferred from Electronic Annotation more info
extracellular vesicular exosome	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

Go to the top of the page Help

Preferred Names: programmed cell death 1 ligand 1

Names: programmed cell death 1 ligand 1; B7 homolog 1; CD274 antigen; PDCD1 ligand 1; programmed death ligand 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001267706.1 → NP_001254635.1 programmed cell death 1 ligand 1 isoform b precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.

Source sequence(s)

AI826502, AL135786, AL162253, AY291313, DQ836393

Consensus CDS

CCDS59118.1

UniProtKB/TrEMBL

Q0GN75

UniProtKB/TrEMBL

Q2V8D5

UniProtKB/Swiss-Prot

Q9NZQ7

Related

ENSP00000370985, ENST00000381573

Conserved Domains (1) summary

cd00098
Location:39 – 96
Blast Score: 97

IgC; Immunoglobulin Constant domain
NM_014143.3 → NP_054862.1 programmed cell death 1 ligand 1 isoform a precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

AI826502, AK314567, AL135786, AL162253

Consensus CDS

CCDS6464.1

UniProtKB/Swiss-Prot

Q9NZQ7

Related

ENSP00000370989, OTTHUMP00000021029, ENST00000381577, OTTHUMT00000051631

Conserved Domains (3) summary

cd00098
Location:153 – 210
Blast Score: 101

IgC; Immunoglobulin Constant domain

pfam07686
Location:18 – 130
Blast Score: 106

V-set; Immunoglobulin V-set domain

cl11960
Location:66 – 114
Blast Score: 120

Ig; Immunoglobulin domain

RNA

NR_052005.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AI826502, AL135786, AL162253, AY714881, DQ836393

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000009.11 Reference GRCh37.p10 Primary Assembly

Range

5450503..5470567

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000141.1 Alternate HuRef

Range

5406210..5426274

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018920.1 Alternate CHM1_1.0

Range

5446168..5466230

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01065413.1 (77308..97372)	None
genomic	AL135786.17 (152583..156592)	None
genomic	AL162253.17 (100..16154)	None
genomic	AMYH01019203.1 (103124..123186)	None
genomic	CH471071.2	EAW58763.1
genomic	JA738699.1	CCF77002.1
mRNA	AF177937.1	AAF25807.1
mRNA	AF233516.1	AAG18508.1
mRNA	AI826502.1	None
mRNA	AK001894.1	BAA91966.1
mRNA	AK300470.1	BAG62189.1
mRNA	AK314567.1	BAG37149.1
mRNA	AY254342.1	AAP13470.1
mRNA	AY291313.1	AAP42144.1
mRNA	AY714881.1	AAU09634.1
mRNA	BC069381.1	AAH69381.1
mRNA	BC074984.2	AAH74984.1
mRNA	BC113734.1	AAI13735.1
mRNA	BC113736.1	AAI13737.1
mRNA	DQ286582.1	ABB90152.1
mRNA	DQ836393.1	ABI16084.1
other-genetic	HQ258151.1	ADR82905.1