TNNT2 troponin T2, cardiac type [Bos taurus (cattle)] - Gene

Summary

Official Symbol: TNNT2provided by VGNC
Official Full Name: troponin T2, cardiac typeprovided by VGNC
Primary source: VGNC:VGNC:36195
See related: Ensembl:ENSBTAG00000045789
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	16	NC_037343.1 (80931674..80943043)

Chromosome 16 - NC_037343.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Significant changes in thin filament Ca2+-sensitivity, structure and kinetics are brought about through PKC phosphorylation of cardiac troponin T.
Title: FRET study of the structural and kinetic effects of PKC phosphomimetic cardiac troponin T mutants on thin filament regulation.
The mu-calpain-mediated proteolytic modification of TnT by removing the NH2-terminal variable region of TnT may act as an acute mechanism to adjust muscle contractility under stress conditions.
Title: Selective deletion of the NH2-terminal variable region of cardiac troponin T in ischemia reperfusion by myofibril-associated mu-calpain cleavage.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables tropomyosin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables troponin C binding	IEA Inferred from Electronic Annotation more info	PubMed
enables troponin I binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cardiac muscle contraction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of muscle contraction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sarcomere organization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of troponin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: troponin T, cardiac muscle

Names: cTnT; cardiac muscle troponin T; tnTc

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.