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    Adck5 aarF domain containing kinase 5 [ Mus musculus (house mouse) ]

    Gene ID: 268822, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Adck5provided by MGI
    Official Full Name
    aarF domain containing kinase 5provided by MGI
    Primary source
    MGI:MGI:2679274
    See related
    Ensembl:ENSMUSG00000022550 AllianceGenome:MGI:2679274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A230108P17
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to act upstream of or within phosphorylation. Located in mitochondrion. Is expressed in several structures, including adrenal gland; genitourinary system; heart; spleen; and submandibular gland. Orthologous to human ADCK5 (aarF domain containing kinase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 67.0), ovary adult (RPKM 62.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adck5 in Genome Data Viewer
    Location:
    15 D3; 15 36.1 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76460559..76480012)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76576359..76595812)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3144 Neighboring gene solute carrier protein 52, member 2 Neighboring gene predicted gene, 35739 Neighboring gene STARR-positive B cell enhancer ABC_E9913 Neighboring gene cleavage and polyadenylation specific factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E1480 Neighboring gene STARR-seq mESC enhancer starr_39057 Neighboring gene solute carrier family 39 (zinc transporter), member 4 Neighboring gene vacuolar protein sorting 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Roma G, et al. Genome Res, 2007 Jul. PMID 17540781, Free PMC Article
    2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
    3. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC69569

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized aarF domain-containing protein kinase 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172960.3 → NP_766548.2  uncharacterized aarF domain-containing protein kinase 5

      See identical proteins and their annotated locations for NP_766548.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes a functional protein.
      Source sequence(s)
      AK039217, BC060528, BQ886383
      Consensus CDS
      CCDS27576.2
      UniProtKB/Swiss-Prot
      Q80V03, Q8CAA3
      UniProtKB/TrEMBL
      E9PUK2
      Related
      ENSMUSP00000125055.2, ENSMUST00000162503.8
      Conserved Domains (2) summary
      COG0661
      Location:78 → 568
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13969
      Location:169 → 420
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    RNA

    1. NR_073123.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK039217, BC060528
      Related
      ENSMUST00000161732.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76460559..76480012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80V03.2 GenPept UniProtKB/Swiss-Prot:Q80V03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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