Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    MCM9 minichromosome maintenance complex component 9 [ Homo sapiens (human) ]

    Gene ID: 254394, updated on 5-May-2013
    Official Symbol
    MCM9provided by HGNC
    Official Full Name
    minichromosome maintenance complex component 9provided by HGNC
    Primary source
    HGNC:21484
    Locus tag
    RP3-329L24.2
    See related
    Ensembl:ENSG00000111877; HPRD:17472; MIM:610098; Vega:OTTHUMG00000015468
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCMDC1; C6orf61; dJ329L24.1; dJ329L24.3
    Summary
    The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]
    Location :
    6q22.31
    Sequence :
    Chromosome: 6; NC_000006.11 (119134612..119256327, complement)
    See MCM9 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene centrosomal protein 85kDa-like Neighboring gene SSX family pseudogene 10 Neighboring gene selenoprotein K pseudogene Neighboring gene anti-silencing function 1A histone chaperone Neighboring gene family with sequence similarity 184, member A Neighboring gene microRNA 548b Neighboring gene mannosidase, alpha, class 1A, member 1 Neighboring gene ribosomal protein L13a pseudogene 15

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Bennett EJ, et al. Cell, 2010 Dec 10. PMID 21145461.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. How to load a replicative helicase onto chromatin: a more and more complex matter during evolution. Lutzmann M, et al. Cell Cycle, 2009 May 1. PMID 19342892.
    5. Ancient diversification of eukaryotic MCM DNA replication proteins. Liu Y, et al. BMC Evol Biol, 2009 Mar 17. PMID 19292915.

    See all (13) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Cdt1, with its two opposing regulatory binding factors MCM9 and geminin, appears to be a major platform on the pre-replication complexes to integrate cell-cycle signals.
      Title: MCM9 binds Cdt1 and is required for the assembly of prereplication complexes.
    2. We also show that the very recently reported human MCM9 protein (HsMCM9), which resembles a truncated MCM-like protein missing a part of the MCM2-7 signature domain, is an incomplete form of the full length HsMCM9 described here.
      Title: Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family.
    3. Identified a novel MCM family gene, MCM9, by using bioinformatics; mouse MCM9 mRNA was upregulated by transcription factor E2E1 and serum stimulation in NIH3T3 cells.
      Title: Identification of a novel cell-cycle-induced MCM family protein MCM9.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:129033 BioGRID:120937 CAND1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:129033 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ13942, FLJ20170, FLJ56845, MGC35304

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    		  
    female gamete generation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    		  
    Component Evidence Code Pubs
    MCM8-MCM9 complex IDA
    Inferred from Direct Assay
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    DNA helicase MCM9
    Names
    DNA helicase MCM9
    DNA replication licensing factor MCM9
    minichromosome maintenance deficient domain containing 1
    mini-chromosome maintenance deficient domain-containing protein 1
    NP_060166.2
    NP_694987.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017696.2 → NP_060166.2  DNA helicase MCM9 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL132874, AL359634, BN000882
      Consensus CDS
      CCDS56447.1
      UniProtKB/Swiss-Prot
      Q9NXL9
      Related
      ENSP00000314505, OTTHUMP00000017099, ENST00000316316, OTTHUMT00000042005
      Conserved Domains (2) summary
      cd00009
      Location:346 – 489
      Blast Score: 109
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00350
      Location:116 – 603
      Blast Score: 1055
      MCM; minichromosome maintenance proteins

    2. NM_153255.4 → NP_694987.1  DNA helicase MCM9 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate 3' terminal exon and lacks 6 exons in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL132874, BC024976, BC031658, DB453085
      Consensus CDS
      CCDS5121.1
      UniProtKB/Swiss-Prot
      Q9NXL9
      Related
      ENSP00000312870, OTTHUMP00000017098, ENST00000316068, OTTHUMT00000042004
      Conserved Domains (2) summary
      COG1241
      Location:10 – 385
      Blast Score: 512
      MCM2; Predicted ATPase involved in replication control, Cdc46/Mcm family [DNA replication, recombination, and repair]
      cl09099
      Location:347 – 375
      Blast Score: 88
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p10 Primary Assembly

      Range
      119134612..119256327, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      116716601..116838443, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018917.1 Alternate CHM1_1.0

      Range
      119136328..119258122, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01026024.1 (61837..179559) None
    genomic ABBA01026024.1 (101670..137640) None
    genomic ABBA01026025.1 None
    genomic AL132874.31 None
    genomic AL359634.20 (123969..169865) None
    genomic AMYH01016623.1 (337964..418432) None
    genomic AMYH01016624.1 None
    genomic CH471051.2 EAW48191.1
      EAW48192.1
    mRNA AK000177.1 BAA90991.1
    mRNA AK122665.1 BAG53653.1
    mRNA AK225233.1 None
    mRNA AK299076.1 BAG61142.1
    mRNA BC024976.1 None
    mRNA BC031658.1 AAH31658.1
    mRNA BN000882.1 CAJ70648.1
    mRNA BX649114.1 None
    mRNA DB453085.1 None
    mRNA DB476942.1 None
    other-genetic DQ892465.2 ABM83391.1
    other-genetic DQ895678.2 ABM86604.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NXL9.4 GenPept UniProtKB/Swiss-Prot:Q9NXL9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...