plo1 Polo kinase Plo1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

Go to the top of the page Help

Gene symbol: plo1
Gene description: Polo kinase Plo1
Primary source: PomBase:SPAC23C11.16
Locus tag: SPAC23C11.16
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_003424.3 (2164162..2166765)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast.
Title: Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast.
Study shows that fission yeast Moa1 (meikin), which associates stably with CENP-C during meiosis I, recruits Plo1 (polo-like kinase) to the kinetochores and phosphorylates Spc7 (KNL1) to accumulate Bub1. Consequently, in contrast to the transient kinetochore localization of mitotic Bub1, meiotic Bub1 persists at kinetochores until anaphase I.
Title: Meikin-associated polo-like kinase specifies Bub1 distribution in meiosis I.
The data presented in this study suggest there are at least two, genetically separable, states of the septation initiation network; an early state that is dependent upon Plo1p for its establishment, and a late state, which is dependent upon Spg1p.
Title: Analysis of S. pombe SIN protein association to the SPB reveals two genetically separable states of the SIN.
Substitution of a conserved methionine residue to phenylalanine in Plo1, Orb5 and Wee1 kinases increased the sensitivities to ATP analogues.
Title: Mutation of a conserved residue enhances the sensitivity of analogue-sensitised kinases to generate a novel approach to the study of mitosis in fission yeast.
PP1 recruitment to Cut12 sets a threshold for Polo's feedback-loop activity that locks the cell in interphase until Cdc25 pushes MPF activity through this barrier to initiate mitosis.
Title: Removal of centrosomal PP1 by NIMA kinase unlocks the MPF feedback loop to promote mitotic commitment in S. pombe.
Dam1 phosphorylation by Plo1 is dispensable for DASH assembly and chromosome retrieval but instead aids tension-dependent chromosome bi-orientation
Title: Plo1 phosphorylates Dam1 to promote chromosome bi-orientation in fission yeast.
Plo1 and a centrin play central roles in the meiotic spindle pole body remodeling
Title: Spindle pole body components are reorganized during fission yeast meiosis.
Plo1 facilitates contractile ring assembly at mitotic onset by regulating myosin II recruitment by Mid1/anillin.
Title: Temporal control of contractile ring assembly by Plo1 regulation of myosin II recruitment by Mid1/anillin.
pericentrin-like Pcp1 regulates multiple functions of the spindle pole body (SPB) through recruiting two critical factors, the gamma-tubulin complex (gamma-TuC) and polo kinase (Plo1)
Title: Fission yeast Pcp1 links polo kinase-mediated mitotic entry to gamma-tubulin-dependent spindle formation.
Plo1p controls M-G1-phase gene transcription through a combination of phosphorylation and cell-cycle-specific DNA binding to Pombe cell cycle boxes.
Title: Regulation of gene expression during M-G1-phase in fission yeast through Plo1p and forkhead transcription factors.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in homologous chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic centromere clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic centromeric cohesion protection in anaphase I	EXP Inferred from Experiment more info	PubMed
involved_in meiotic centromeric cohesion protection in anaphase I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic spindle pole body organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic division septum assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic metaphase/anaphase transition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mitotic sister chromatid biorientation	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of septation initiation signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle attachment to meiosis I kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	HDA more info	PubMed
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
is_active_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
is_active_in meiotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in meiotic spindle pole	IDA Inferred from Direct Assay more info	PubMed
is_active_in meiotic spindle pole body	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle pole body	HDA more info	PubMed
is_active_in mitotic spindle pole body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolar peripheral inclusion body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle pole body	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Polo kinase Plo1

NP_593647.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

2164162..2166765

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001019078.2 → NP_593647.1 Polo kinase Plo1 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_593647.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P50528

Conserved Domains (4) summary

smart00220
Location:41 → 296

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13117
Location:599 → 676

POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd13118
Location:490 → 580

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd14099
Location:41 → 296

STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases