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Pdgfa platelet derived growth factor subunit A [ Rattus norvegicus (Norway rat) ]

Gene ID: 25266, updated on 13-Apr-2024

Summary

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Official Symbol: Pdgfaprovided by RGD
Official Full Name: platelet derived growth factor subunit Aprovided by RGD
Primary source: RGD:3282
See related: Ensembl:ENSRNOG00000001312 AllianceGenome:RGD:3282
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PDGFACP
Summary: Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in several processes, including male gonad development; response to estradiol; and response to retinoic acid. Predicted to be located in cell surface and microvillus. Predicted to be active in extracellular space. Biomarker of chronic ulcer of skin; oligohydramnios; pancreatitis; pulmonary hypertension; and renovascular hypertension. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 73.3), Heart (RPKM 72.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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Location:: 12q11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (20759366..20780337)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (15645549..15667056)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (17734141..17756186)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Platelet derived growth factor-A (Pdgf-a) gene transfer modulates scar composition and improves left ventricular function after myocardial infarction.
Title: Platelet derived growth factor-A (Pdgf-a) gene transfer modulates scar composition and improves left ventricular function after myocardial infarction.
an Ntv-a transgenic rat colony was established and used to study glial brain tumors driven by two well-characterized oncogenic gene transformations, PDGFA overexpression and p53 depletion. Combined PDGFA and p53 alterations resulted in large, heterogeneous tumors in all affected animals
Title: Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer.
Combined inhibition of PGDF and VEGF with sunitinib prevents chronic rejection changes in experimental kidney transplantation.
Title: Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in Experimental Kidney Transplantation Model.
expression altered in experimental Necrotizing enterocolitis
Title: Alterations in platelet-derived growth factor expression in the pathophysiology of necrotizing enterocolitis.
PDGF regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1.
Title: Platelet-derived growth factor regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1.
Replacing heregulin, PDGF-AA and bFGF with T3 for 6 days resulted in repression of O4, O1, Olig2 and PDGFR-a
Title: Differentiation of neurosphere-derived rat neural stem cells into oligodendrocyte-like cells by repressing PDGF-α and Olig2 with triiodothyronine.
observations indicated that PDGF can contribute to the development of cardiac interstitial fibrosis in the noninfarcted myocardium, but does not alter scar formation in the infarcted myocardium.
Title: Platelet-derived growth factor blockade on cardiac remodeling following infarction.
We detected the expression and levels of PDGF-AA, bFGF and IGF-1 in neuroblastoma cells and in conditioned media which stimulated proliferation of oligodendrocyte precursor cells.
Title: PDGF-AA and bFGF mediate B104CM-induced proliferation of oligodendrocyte precursor cells.
PDGF-AA contained in B104 neuroblastoma cells is a key regulating molecule that instructs oligodendrocyte differentiation from embryonic stem cells through activation of Erk, PI3K, and p38 signal pathway in vitro.
Title: PDGF-AA mediates B104CM-induced oligodendrocyte precursor cell differentiation of embryonic neural stem cells through Erk, PI3K, and p38 signaling.
Rad is regulated by PDGF through the transcriptional factor Egr-1 in RASMCs
Title: Platelet-derived growth factor induces Rad expression through Egr-1 in vascular smooth muscle cells.

Submit: New GeneRIF Correction See all GeneRIFs (26)

General gene information

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Markers

Pdgfa (e-PCR), detects polymorphism
- UniSTS:144149

Pdgfa (e-PCR), detects polymorphism
- UniSTS:464685

AW525445 (e-PCR)
- UniSTS:245147

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables collagen binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISS Inferred from Sequence or Structural Similarity more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables growth factor activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor binding	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor binding	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables platelet-derived growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in animal organ morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell projection assembly	ISO Inferred from Sequence Orthology more info
involved_in cell projection assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within digestive tract development	ISO Inferred from Sequence Orthology more info
involved_in digestive tract development	ISO Inferred from Sequence Orthology more info
involved_in embryonic lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in hair follicle development	ISS Inferred from Sequence or Structural Similarity more info
involved_in inner ear development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
involved_in lung alveolus development	ISO Inferred from Sequence Orthology more info
involved_in lung alveolus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in negative chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of phosphatidylinositol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of platelet activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of platelet activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet-derived growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet-derived growth factor receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein autophosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein autophosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of DNA biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in regulation of glomerular mesangial cell proliferation	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of glomerular mesangial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to inorganic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to wounding	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info
involved_in skin development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISS Inferred from Sequence or Structural Similarity more info
part_of platelet-derived growth factor complex	IEA Inferred from Electronic Annotation more info
part_of platelet-derived growth factor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: platelet-derived growth factor subunit A

Names: PDGF subunit A; PDGF-1; Platelet-derived growth factor A chain; platelet derived growth factor, alpha; platelet-derived growth factor alpha polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012801.2 → NP_036933.2 platelet-derived growth factor subunit A precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P28576

UniProtKB/TrEMBL

A6K1Y7

Related

ENSRNOP00000040116.4, ENSRNOT00000042117.7

Conserved Domains (2) summary

smart00141
Location:94 → 181

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam04692
Location:21 → 95

PDGF_N; Platelet-derived growth factor, N terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

20759366..20780337

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089107.2 → XP_038945035.1 platelet-derived growth factor subunit A isoform X2

UniProtKB/Swiss-Prot

P28576

UniProtKB/TrEMBL

A0A0G2K8Y8, A6K1Y8, Q6P7C3

Conserved Domains (2) summary

smart00141
Location:94 → 181

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam04692
Location:21 → 95

PDGF_N; Platelet-derived growth factor, N terminal region
XM_039089106.2 → XP_038945034.1 platelet-derived growth factor subunit A isoform X1

UniProtKB/Swiss-Prot

P28576

UniProtKB/TrEMBL

A6K1Y7

Conserved Domains (2) summary

smart00141
Location:94 → 181

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam04692
Location:21 → 95

PDGF_N; Platelet-derived growth factor, N terminal region