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    Fmo1 flavin containing dimethylaniline monoxygenase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25256, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fmo1provided by RGD
    Official Full Name
    flavin containing dimethylaniline monoxygenase 1provided by RGD
    Primary source
    RGD:2622
    See related
    Ensembl:ENSRNOG00000034191 AllianceGenome:RGD:2622
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RFMO1A
    Summary
    Enables N,N-dimethylaniline monooxygenase activity. Involved in response to lipopolysaccharide and response to osmotic stress. Located in intracellular membrane-bounded organelle. Orthologous to human FMO1 (flavin containing dimethylaniline monoxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 1119.2), Lung (RPKM 550.7) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fmo1 in Genome Data Viewer
    Location:
    13q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (77715405..77747666, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (75182184..75214439, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (80712885..80745095, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene proline-rich coiled-coil 2C Neighboring gene uncharacterized LOC134481577 Neighboring gene uncharacterized LOC102555487 Neighboring gene flavin containing dimethylaniline monoxygenase 4 Neighboring gene heat shock protein 90 alpha family class A member 1, pseudogene 13 Neighboring gene flavin containing dimethylaniline monoxygenase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Flavin-containing monooxygenase, a new clue of pathological proteins in the rotenone model of parkinsonism. Li B, et al. Neurosci Lett, 2014 Apr 30. PMID 24440618
    2. Effect of hyperosmotic conditions on flavin-containing monooxygenase activity, protein and mRNA expression in rat kidney. Rodríguez-Fuentes G, et al. Toxicol Lett, 2009 Jun 1. PMID 19429252, Free PMC Article
    3. Hepatic flavin-containing monooxygenase activity attenuated by cGMP-independent nitric oxide-mediated mRNA destabilization. Ryu SD, et al. Biochem Biophys Res Commun, 2004 Nov 5. PMID 15465034
    4. Rat liver flavin-containing monooxygenase (FMO): cDNA cloning and expression in yeast. Itoh K, et al. Biochim Biophys Acta, 1993 May 28. PMID 8504165
    5. Lipopolysaccharide-induced epithelial monoamine oxidase mediates alveolar bone loss in a rat chronic wound model. Ekuni D, et al. Am J Pathol, 2009 Oct. PMID 19779138, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FMO, whose dysfunction could be a reason for the apoptosis of dopaminergic neurons in rotenone model, might be a new clue of pathological proteins in rotenone model of parkinsonism
      Title: Flavin-containing monooxygenase, a new clue of pathological proteins in the rotenone model of parkinsonism.
    2. Data show a compelling visual demonstration of the isoform-specific localization patterns of FMO1, -3, and -4 in the rat liver and kidney and the first evidence for expression of FMO4 at the protein level in mouse and human liver and kidney microsomes.
      Title: Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes.
    3. results suggest that nitric oxide acts directly in a cyclic GMP-independent mechanism by decreasing the half-life of flavin-containing monooxygenase 1 (FMO1) mRNA, thereby inducing impairment of FMO-related functions in endotoxemia
      Title: Hepatic flavin-containing monooxygenase activity attenuated by cGMP-independent nitric oxide-mediated mRNA destabilization.
    4. the relationship between gender and development in the expression of FMO1 in the liver and kidney was determined
      Title: Physiological factors affecting the expression of FMO1 and FMO3 in the rat liver and kidney.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N,N-dimethylaniline monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N,N-dimethylaniline monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N,N-dimethylaniline monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N,N-dimethylaniline monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hypotaurine dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hypotaurine dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables trimethylamine monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NADPH oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in taurine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in taurine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in toxin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    flavin-containing monooxygenase 1
    Names
    FMO 1
    Flavin-containing monooxygenase 1
    dimethylaniline monooxygenase [N-oxide-forming] 1
    dimethylaniline oxidase 1
    flavin containing monooxygenase 1
    hepatic flavin-containing monooxygenase 1
    trimethylamine monooxygenase
    NP_036924.1
    XP_006250207.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012792.1 → NP_036924.1  flavin-containing monooxygenase 1

      See identical proteins and their annotated locations for NP_036924.1

      Status: PROVISIONAL

      Source sequence(s)
      M84719
      UniProtKB/TrEMBL
      A0A8L2R702
      Related
      ENSRNOP00000044613.1, ENSRNOT00000041908.4
      Conserved Domains (2) summary
      pfam00743
      Location:3 → 532
      FMO-like; Flavin-binding monooxygenase-like
      cl21454
      Location:81 → 342
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      77715405..77747666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250145.5 → XP_006250207.1  flavin-containing monooxygenase 1 isoform X1

      See identical proteins and their annotated locations for XP_006250207.1

      UniProtKB/Swiss-Prot
      P36365, Q6P7Q5
      UniProtKB/TrEMBL
      A0A8L2R702, A6IDA3
      Conserved Domains (2) summary
      pfam00743
      Location:3 → 532
      FMO-like; Flavin-binding monooxygenase-like
      cl21454
      Location:81 → 342
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36365.2 GenPept UniProtKB/Swiss-Prot:P36365

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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