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    Cox8b cytochrome c oxidase, subunit VIIIb [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25250, updated on 29-Feb-2024

    Summary

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    Official Symbol
    Cox8bprovided by RGD
    Official Full Name
    cytochrome c oxidase, subunit VIIIbprovided by RGD
    Primary source
    RGD:2386
    See related
    AllianceGenome:RGD:2386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CCO8A; Cox8h; COXVIII-H
    Summary
    Predicted to enable cytochrome-c oxidase activity. Involved in response to xenobiotic stimulus. Predicted to be integral component of membrane. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrion. Used to study obesity. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 12462.9), Muscle (RPKM 9124.6) and 1 other tissue See more
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    Genomic context

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    Location:
    1q41
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205406813..205408273, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (195977183..195978643, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (213648787..213650247, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene sirtuin 3 Neighboring gene proteasome 26S subunit, non-ATPase 13 Neighboring gene NLR family, pyrin domain containing 6 Neighboring gene protein-glucosylgalactosylhydroxylysine glucosidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DNA microarray analysis of white adipose tissue from obese (fa/fa) Zucker rats treated with a beta3-adrenoceptor agonist, KTO-7924. Oana F, et al. Pharmacol Res, 2005 Nov. PMID 16027000
    2. The role of an E box binding basic helix loop helix protein in the cardiac muscle-specific expression of the rat cytochrome oxidase subunit VIII gene. Lenka N, et al. J Biol Chem, 1996 Nov 22. PMID 8939982
    3. Nucleotide sequence of cDNA encoding subunit VIII of cytochrome c oxidase from rat heart. Scheja K, et al. Biochim Biophys Acta, 1992 Aug 17. PMID 1324738
    4. Gene expression profile of cardiomyocytes in hypertrophic heart induced by continuous norepinephrine infusion in the rats. Li P, et al. Cell Mol Life Sci, 2003 Oct. PMID 14618266
    5. Tissue- and species-specific expression of cytochrome c oxidase isozymes in vertebrates. Kadenbach B, et al. Biochim Biophys Acta, 1990 Feb 2. PMID 2153407

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytochrome-c oxidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 8B, mitochondrial
    Names
    Cytochrom c oxidase subunit VIII-H (heart/muscle)
    Cytochrome c oxidase subunit VIII-H (heart/muscle)
    cytochrome c oxidase polypeptide VIII-heart
    cytochrome c oxidase subunit 8-1
    cytochrome c oxidase subunit 8H
    cytochrome c oxidase, subunit 8B
    cytochrome c oxidase, subunit VIIIb, muscle
    NP_036918.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012786.3 → NP_036918.2  cytochrome c oxidase subunit 8B, mitochondrial precursor

      See identical proteins and their annotated locations for NP_036918.2

      Status: VALIDATED

      Source sequence(s)
      FM054348, X64827
      UniProtKB/Swiss-Prot
      P16221
      UniProtKB/TrEMBL
      A6HXL6
      Conserved Domains (1) summary
      pfam02285
      Location:26 → 66
      COX8; Cytochrome oxidase c subunit VIII

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      205406813..205408273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16221.3 GenPept UniProtKB/Swiss-Prot:P16221

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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