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    Stk38l serine/threonine kinase 38 like [ Mus musculus (house mouse) ]

    Gene ID: 232533, updated on 16-Apr-2024

    Summary

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    Official Symbol
    Stk38lprovided by MGI
    Official Full Name
    serine/threonine kinase 38 likeprovided by MGI
    Primary source
    MGI:MGI:1922250
    See related
    Ensembl:ENSMUSG00000001630 AllianceGenome:MGI:1922250
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ndr2; Ndr54; 4930473A22Rik
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in regulation of cellular component organization. Located in actin cytoskeleton and cytoplasm. Orthologous to human STK38L (serine/threonine kinase 38 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 3.6), frontal lobe adult (RPKM 3.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stk38l in Genome Data Viewer
    Location:
    6 G3; 6 77.7 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (146626428..146680312)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (146724930..146778814)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930479D17 gene Neighboring gene mediator complex subunit 21 Neighboring gene predicted pseudogene 6654 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:146623095-146623296 Neighboring gene STARR-positive B cell enhancer ABC_E6504 Neighboring gene STARR-seq mESC enhancer starr_17805 Neighboring gene STARR-positive B cell enhancer ABC_E1332 Neighboring gene STARR-seq mESC enhancer starr_17807 Neighboring gene STARR-seq mESC enhancer starr_17808 Neighboring gene STARR-seq mESC enhancer starr_17809 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene basic helix-loop-helix ARNT like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation. Wang S, et al. Cell Rep, 2022 Nov 22. PMID 36417850
    2. NDR functions as a physiological YAP1 kinase in the intestinal epithelium. Zhang L, et al. Curr Biol, 2015 Feb 2. PMID 25601544, Free PMC Article
    3. The serine/threonine kinase Ndr2 controls integrin trafficking and integrin-dependent neurite growth. Rehberg K, et al. J Neurosci, 2014 Apr 9. PMID 24719112, Free PMC Article
    4. Neuronal functions of the novel serine/threonine kinase Ndr2. Stork O, et al. J Biol Chem, 2004 Oct 29. PMID 15308672
    5. Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein. Stegert MR, et al. J Biol Chem, 2004 May 28. PMID 15037617

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation.
      Title: LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation.
    2. NDR1/2 functions as a physiological YAP1 kinase in the intestinal epithelium.
      Title: NDR functions as a physiological YAP1 kinase in the intestinal epithelium.
    3. Ndr2 is an interesting candidate gene for the regulation of structural processes in differentiating and mature neuronal cells.
      Title: Neuronal functions of the novel serine/threonine kinase Ndr2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • B230328I19

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cellular component organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 38-like
    Names
    nuclear Dbf2-related kinase 2
    NP_001333595.1
    NP_766322.1
    XP_006507090.2
    XP_006507092.1
    XP_006507094.1
    XP_006507095.1
    XP_017177049.1
    XP_030111217.1
    XP_030111218.1
    XP_030111220.1
    XP_036021983.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346666.1 → NP_001333595.1  serine/threonine-protein kinase 38-like isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which as a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK045971, AY223819, BE946381, BY434134, CJ082246
      UniProtKB/Swiss-Prot
      Q7TSE6
      Conserved Domains (1) summary
      cl21453
      Location:1 → 335
      PKc_like; Protein Kinases, catalytic domain

    2. NM_172734.3 → NP_766322.1  serine/threonine-protein kinase 38-like isoform 1

      See identical proteins and their annotated locations for NP_766322.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC164631, AK052288, CJ082246
      Consensus CDS
      CCDS39712.1
      UniProtKB/Swiss-Prot
      B2KFR4, Q6P6K6, Q7TSE6, Q8BWK4
      Related
      ENSMUSP00000001675.8, ENSMUST00000001675.14
      Conserved Domains (2) summary
      smart00220
      Location:90 → 383
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05627
      Location:87 → 452
      STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      146626428..146680312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507027.2 → XP_006507090.2  serine/threonine-protein kinase 38-like isoform X1

      See identical proteins and their annotated locations for XP_006507090.2

      UniProtKB/Swiss-Prot
      Q7TSE6
      Related
      ENSMUSP00000107271.2, ENSMUST00000111644.2
      Conserved Domains (1) summary
      cd05627
      Location:87 → 459
      STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

    2. XM_036166090.1 → XP_036021983.1  serine/threonine-protein kinase 38-like isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:87 → 391
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006507032.4 → XP_006507095.1  serine/threonine-protein kinase 38-like isoform X7

      See identical proteins and their annotated locations for XP_006507095.1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 342
      PKc_like; Protein Kinases, catalytic domain

    4. XM_030255358.2 → XP_030111218.1  serine/threonine-protein kinase 38-like isoform X6

      Conserved Domains (1) summary
      cd05627
      Location:35 → 400
      STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

    5. XM_006507031.3 → XP_006507094.1  serine/threonine-protein kinase 38-like isoform X5

      See identical proteins and their annotated locations for XP_006507094.1

      Conserved Domains (1) summary
      cd05627
      Location:35 → 407
      STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

    6. XM_017321560.3 → XP_017177049.1  serine/threonine-protein kinase 38-like isoform X8

      Conserved Domains (1) summary
      cl21453
      Location:1 → 335
      PKc_like; Protein Kinases, catalytic domain

    7. XM_030255360.2 → XP_030111220.1  serine/threonine-protein kinase 38-like isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:1 → 342
      PKc_like; Protein Kinases, catalytic domain

    8. XM_030255357.2 → XP_030111217.1  serine/threonine-protein kinase 38-like isoform X4

      Conserved Domains (1) summary
      cd05627
      Location:93 → 458
      STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

    9. XM_006507029.5 → XP_006507092.1  serine/threonine-protein kinase 38-like isoform X3

      See identical proteins and their annotated locations for XP_006507092.1

      Conserved Domains (1) summary
      cd05627
      Location:93 → 465
      STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

    RNA

    1. XR_004942946.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSE6.2 GenPept UniProtKB/Swiss-Prot:Q7TSE6

    Gene LinkOut

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