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    ERC1 ELKS/RAB6-interacting/CAST family member 1 [ Homo sapiens (human) ]

    Gene ID: 23085, updated on 7-Apr-2024

    Summary

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    Official Symbol
    ERC1provided by HGNC
    Official Full Name
    ELKS/RAB6-interacting/CAST family member 1provided by HGNC
    Primary source
    HGNC:HGNC:17072
    See related
    Ensembl:ENSG00000082805 MIM:607127; AllianceGenome:HGNC:17072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ELKS; Cast2; ERC-1; RAB6IP2
    Summary
    The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in thyroid (RPKM 7.0), esophagus (RPKM 6.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    12p13.33
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (989959..1495933)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (985850..1490194)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (1100389..1605099)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, U4atac small nuclear 16, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5791 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:917646-918146 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:918147-918647 Neighboring gene WNK lysine deficient protein kinase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5792 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:1023012-1024211 Neighboring gene uncharacterized LOC124902855 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:1058032-1058690 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:1058691-1059349 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1067429-1067930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1067931-1068430 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:1083331-1083878 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:1092618-1092819 Neighboring gene RAD52 homolog, DNA repair protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:1099220-1099782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:1100344-1100905 Neighboring gene Sharpr-MPRA regulatory region 6010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1115216-1115716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1115717-1116217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1181067-1181567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5795 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:1224566-1225765 Neighboring gene uncharacterized LOC124902857 Neighboring gene 5-hydroxytryptamine receptor 1D pseudogene 1 Neighboring gene uncharacterized LOC124902854 Neighboring gene NANOG hESC enhancer GRCh37_chr12:1359724-1360323 Neighboring gene MPRA-validated peak1534 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1412737-1413279 Neighboring gene uncharacterized LOC107987182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1551257-1551756 Neighboring gene uncharacterized LOC124902856 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:1554896-1555397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5797 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:1597926-1599125 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:1608954-1610153 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:1611914-1612112 Neighboring gene uncharacterized LOC107984507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4113 Neighboring gene long intergenic non-protein coding RNA 942

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Volumetric GWAS of medial temporal lobe structures identifies an ERC1 locus using ADNI high-resolution T2-weighted MRI data. Cong S, et al. Neurobiol Aging, 2020 Nov. PMID 32768867, Free PMC Article
    2. Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells. Ohara-Imaizumi M, et al. Mol Metab, 2019 Sep. PMID 31500835, Free PMC Article
    3. A 1.5Mb terminal deletion of 12p associated with autism spectrum disorder. Silva IM, et al. Gene, 2014 May 25. PMID 24613754
    4. Rab6 dependent post-Golgi trafficking of HSV1 envelope proteins to sites of virus envelopment. Johns HL, et al. Traffic, 2014 Feb. PMID 24152084, Free PMC Article
    5. Antibodies to active zone protein ERC1 in Lambert-Eaton myasthenic syndrome. Huijbers MG, et al. Hum Immunol, 2013 Jul. PMID 23583364

    See all (118) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interfering with the ERC1-LL5beta interaction disrupts plasma membrane-Associated platforms and affects tumor cell motility.
      Title: Interfering with the ERC1-LL5β interaction disrupts plasma membrane-Associated platforms and affects tumor cell motility.
    2. Oligomerized liprin-alpha promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.
      Title: Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.
    3. Volumetric GWAS of medial temporal lobe structures identifies an ERC1 locus using ADNI high-resolution T2-weighted MRI data.
      Title: Volumetric GWAS of medial temporal lobe structures identifies an ERC1 locus using ADNI high-resolution T2-weighted MRI data.
    4. The ELKS forms a potent insulin secretion complex with L-type voltage-dependent Ca(2+) channels on the vascular-facing plasma membrane of beta-cells, enabling polarized Ca(2+) influx and first-phase insulin secretion from islets.
      Title: Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells.
    5. Several studies had established that ELKS is a redundant scaffold at the active zone, and that disruption of this scaffold impairs fusion of synaptic vesicles. In non-neuronal cells, scaffolding and exocytotic functions of ELKS seem to be important for constitutive secretion of other cargo. [review]
      Title: ELKS active zone proteins as multitasking scaffolds for secretion.
    6. Knockdown of ERC1, RAB4B, COPA, and COPB2, caused profound loss of virus production.
      Title: Identification of Host Factors Involved in Human Cytomegalovirus Replication, Assembly, and Egress Using a Two-Step Small Interfering RNA Screen.
    7. The results indicate that liprin-alpha1, LL5 and ERC1 define a novel dynamic membrane-less compartment that regulates matrix degradation by affecting invadosome motility.
      Title: Identification of a membrane-less compartment regulating invadosome function and motility.
    8. ELKS removal has differential, synapse-specific effects on readily releasable vesicles and probability of release, and findings establish important roles for ELKS N-terminal domains in synaptic vesicle priming.
      Title: ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains.
    9. Liprin-alpha1, ERC1a and LL5 also define new highly polarized and dynamic cytoplasmic structures uniquely localized near the protruding cell edge
      Title: Liprin-α1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration.
    10. a new, but rare, antigen in Lambert-Eaton myasthenic syndrome
      Title: Antibodies to active zone protein ERC1 in Lambert-Eaton myasthenic syndrome.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31750, KIAA1081, MGC12974

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables PDZ domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in I-kappaB phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maintenance of presynaptic active zone structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuromuscular synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of IkappaB kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoskeleton of presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ELKS/Rab6-interacting/CAST family member 1
    Names
    RAB6 interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301248.1 → NP_001288177.1  ELKS/Rab6-interacting/CAST family member 1 isoform zeta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (zeta) contains an additional exon that results in an alternate 3' coding region and 3' UTR, compared to variant epsilon. The encoded isoform (zeta) has a distinct C-terminus and is shorter than isoform epsilon. The 5' UTR of this variant is incomplete due to lack of full-length transcript support and splice site ambiguity in the 5'-most exon.
      Source sequence(s)
      AC004671, AC004803, BC144287, BM984956
      Consensus CDS
      CCDS76504.1
      UniProtKB/TrEMBL
      G8JLD3
      Related
      ENSP00000347621.5, ENST00000355446.9
      Conserved Domains (3) summary
      pfam10174
      Location:155 → 982
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam10211
      Location:767 → 832
      Ax_dynein_light; Axonemal dynein light chain
      cl21478
      Location:918 → 989
      ATP-synt_B; ATP synthase B/B' CF(0)

    2. NM_178039.4 → NP_829883.1  ELKS/Rab6-interacting/CAST family member 1 isoform delta

      See identical proteins and their annotated locations for NP_829883.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (delta) lacks an alternate in-frame exon in the central coding region, compared to variant epsilon, resulting in a shorter isoform (delta), compared to isoform epsilon.
      Source sequence(s)
      AB053470, AC004671, AC004803, BM984956, DR000847
      Consensus CDS
      CCDS53732.1
      UniProtKB/Swiss-Prot
      Q8IUD2
      Related
      ENSP00000438546.1, ENST00000543086.7
      Conserved Domains (4) summary
      pfam09457
      Location:1040 → 1080
      RBD-FIP; FIP domain
      pfam10174
      Location:155 → 954
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam10211
      Location:739 → 804
      Ax_dynein_light; Axonemal dynein light chain
      cl21478
      Location:890 → 961
      ATP-synt_B; ATP synthase B/B' CF(0)

    3. NM_178040.4 → NP_829884.1  ELKS/Rab6-interacting/CAST family member 1 isoform epsilon

      See identical proteins and their annotated locations for NP_829884.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (epsilon) encodes the longest isoform (epsilon).
      Source sequence(s)
      AB053471, AC004671, AC004672, AC004803, BM984956, DR000847
      Consensus CDS
      CCDS8508.1
      UniProtKB/Swiss-Prot
      A2RU77, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1
      Related
      ENSP00000354158.3, ENST00000360905.9
      Conserved Domains (4) summary
      pfam09457
      Location:1068 → 1108
      RBD-FIP; FIP domain
      pfam10174
      Location:155 → 982
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam10211
      Location:767 → 832
      Ax_dynein_light; Axonemal dynein light chain
      cl21478
      Location:918 → 989
      ATP-synt_B; ATP synthase B/B' CF(0)

    RNA

    1. NR_027946.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) uses an alternate splice site in the 5' terminal exon, lacks two internal exons, and contains two additional exons, compared to variant epsilon. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant epsilon, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB015617, AC004671, AC004803, BM984956, DR000847

    2. NR_027948.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta) uses an alternate splice site in the 5' terminal exon, lacks one internal exon, and contains two additional exons, compared to variant epsilon. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant epsilon, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB053468, AC004671, AC004803, BM984956, DR000847

    3. NR_027949.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (gamma) lacks five internal exons and contains two additional exons, compared to variant epsilon. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant epsilon, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB053469, AC004671, AC004803, BM984956, DR000847

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      989959..1495933
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428566.1 → XP_047284522.1  ELKS/Rab6-interacting/CAST family member 1 isoform X8

      UniProtKB/Swiss-Prot
      A2RU77, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1

    2. XM_047428562.1 → XP_047284518.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

    3. XM_017019055.3 → XP_016874544.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

    4. XM_047428563.1 → XP_047284519.1  ELKS/Rab6-interacting/CAST family member 1 isoform X7

    5. XM_047428558.1 → XP_047284514.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

    6. XM_047428570.1 → XP_047284526.1  ELKS/Rab6-interacting/CAST family member 1 isoform X9

    7. XM_047428576.1 → XP_047284532.1  ELKS/Rab6-interacting/CAST family member 1 isoform X12

    8. XM_017019054.2 → XP_016874543.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

    9. XM_047428557.1 → XP_047284513.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

    10. XM_047428561.1 → XP_047284517.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

    11. XM_047428565.1 → XP_047284521.1  ELKS/Rab6-interacting/CAST family member 1 isoform X8

      UniProtKB/Swiss-Prot
      A2RU77, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1

    12. XM_047428568.1 → XP_047284524.1  ELKS/Rab6-interacting/CAST family member 1 isoform X9

    13. XM_047428572.1 → XP_047284528.1  ELKS/Rab6-interacting/CAST family member 1 isoform X10

    14. XM_047428574.1 → XP_047284530.1  ELKS/Rab6-interacting/CAST family member 1 isoform X12

    15. XM_047428579.1 → XP_047284535.1  ELKS/Rab6-interacting/CAST family member 1 isoform X15

    16. XM_017019052.2 → XP_016874541.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

    17. XM_017019061.2 → XP_016874550.1  ELKS/Rab6-interacting/CAST family member 1 isoform X5

      Conserved Domains (3) summary
      pfam09457
      Location:1075 → 1115
      RBD-FIP; FIP domain
      pfam10174
      Location:155 → 989
      Cast; RIM-binding protein of the cytomatrix active zone
      cl21478
      Location:925 → 996
      ATP-synt_B; ATP synthase B/B' CF(0)

    18. XM_017019069.2 → XP_016874558.1  ELKS/Rab6-interacting/CAST family member 1 isoform X13

    19. XM_017019059.2 → XP_016874548.1  ELKS/Rab6-interacting/CAST family member 1 isoform X3

    20. XM_017019063.2 → XP_016874552.1  ELKS/Rab6-interacting/CAST family member 1 isoform X7

      Conserved Domains (4) summary
      pfam09457
      Location:1071 → 1111
      RBD-FIP; FIP domain
      pfam10174
      Location:155 → 985
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam10211
      Location:770 → 835
      Ax_dynein_light; Axonemal dynein light chain
      cl21478
      Location:921 → 992
      ATP-synt_B; ATP synthase B/B' CF(0)

    21. XM_017019057.2 → XP_016874546.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

    22. XM_017019062.2 → XP_016874551.1  ELKS/Rab6-interacting/CAST family member 1 isoform X6

      UniProtKB/TrEMBL
      X6RLX0
      Related
      ENSP00000442739.2, ENST00000546231.6
      Conserved Domains (3) summary
      pfam09457
      Location:1072 → 1112
      RBD-FIP; FIP domain
      pfam10174
      Location:155 → 986
      Cast; RIM-binding protein of the cytomatrix active zone
      cl21478
      Location:922 → 993
      ATP-synt_B; ATP synthase B/B' CF(0)

    23. XM_017019060.2 → XP_016874549.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

      Conserved Domains (1) summary
      COG1196
      Location:261 → 986
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    24. XM_017019064.2 → XP_016874553.1  ELKS/Rab6-interacting/CAST family member 1 isoform X8

      UniProtKB/Swiss-Prot
      A2RU77, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1
      Related
      ENSP00000380386.4, ENST00000397203.7
      Conserved Domains (4) summary
      pfam09457
      Location:1068 → 1108
      RBD-FIP; FIP domain
      pfam10174
      Location:155 → 982
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam10211
      Location:767 → 832
      Ax_dynein_light; Axonemal dynein light chain
      cl21478
      Location:918 → 989
      ATP-synt_B; ATP synthase B/B' CF(0)

    25. XM_017019070.2 → XP_016874559.1  ELKS/Rab6-interacting/CAST family member 1 isoform X14

    26. XM_017019065.2 → XP_016874554.1  ELKS/Rab6-interacting/CAST family member 1 isoform X9

    27. XM_017019066.2 → XP_016874555.1  ELKS/Rab6-interacting/CAST family member 1 isoform X11

      Related
      ENSP00000410064.2, ENST00000440394.7

    28. XM_047428571.1 → XP_047284527.1  ELKS/Rab6-interacting/CAST family member 1 isoform X10

    29. XM_017019067.2 → XP_016874556.1  ELKS/Rab6-interacting/CAST family member 1 isoform X12

      UniProtKB/Swiss-Prot
      Q8IUD2
      Conserved Domains (4) summary
      pfam09457
      Location:1040 → 1080
      RBD-FIP; FIP domain
      pfam10174
      Location:155 → 954
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam10211
      Location:739 → 804
      Ax_dynein_light; Axonemal dynein light chain
      cl21478
      Location:890 → 961
      ATP-synt_B; ATP synthase B/B' CF(0)

    30. XM_047428578.1 → XP_047284534.1  ELKS/Rab6-interacting/CAST family member 1 isoform X15

    31. XM_017019072.2 → XP_016874561.1  ELKS/Rab6-interacting/CAST family member 1 isoform X16

    32. XM_047428580.1 → XP_047284536.1  ELKS/Rab6-interacting/CAST family member 1 isoform X17

    33. XM_047428583.1 → XP_047284539.1  ELKS/Rab6-interacting/CAST family member 1 isoform X20

    34. XM_047428581.1 → XP_047284537.1  ELKS/Rab6-interacting/CAST family member 1 isoform X18

    35. XM_047428584.1 → XP_047284540.1  ELKS/Rab6-interacting/CAST family member 1 isoform X21

      UniProtKB/TrEMBL
      X6RM00
      Related
      ENSP00000445336.2, ENST00000542302.6

    36. XM_047428582.1 → XP_047284538.1  ELKS/Rab6-interacting/CAST family member 1 isoform X19

    37. XM_017019056.2 → XP_016874545.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

    38. XM_047428559.1 → XP_047284515.1  ELKS/Rab6-interacting/CAST family member 1 isoform X3

    39. XM_047428564.1 → XP_047284520.1  ELKS/Rab6-interacting/CAST family member 1 isoform X7

    40. XM_047428556.1 → XP_047284512.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

    41. XM_047428560.1 → XP_047284516.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

    42. XM_047428567.1 → XP_047284523.1  ELKS/Rab6-interacting/CAST family member 1 isoform X8

      UniProtKB/Swiss-Prot
      A2RU77, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1
      Related
      ENSP00000468263.1, ENST00000589028.6

    43. XM_047428577.1 → XP_047284533.1  ELKS/Rab6-interacting/CAST family member 1 isoform X14

    44. XM_047428569.1 → XP_047284525.1  ELKS/Rab6-interacting/CAST family member 1 isoform X9

    45. XM_047428573.1 → XP_047284529.1  ELKS/Rab6-interacting/CAST family member 1 isoform X10

    46. XM_047428575.1 → XP_047284531.1  ELKS/Rab6-interacting/CAST family member 1 isoform X12

    47. XM_017019074.2 → XP_016874563.1  ELKS/Rab6-interacting/CAST family member 1 isoform X22

    RNA

    1. XR_001748631.3 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_013171809.1 Reference GRCh38.p14 PATCHES

      Range
      38589..100408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      985850..1490194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371509.1 → XP_054227484.1  ELKS/Rab6-interacting/CAST family member 1 isoform X8

      UniProtKB/Swiss-Prot
      A2RU77, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1

    2. XM_054371501.1 → XP_054227476.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

    3. XM_054371492.1 → XP_054227467.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

    4. XM_054371507.1 → XP_054227482.1  ELKS/Rab6-interacting/CAST family member 1 isoform X7

    5. XM_054371496.1 → XP_054227471.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

    6. XM_054371514.1 → XP_054227489.1  ELKS/Rab6-interacting/CAST family member 1 isoform X9

    7. XM_054371520.1 → XP_054227495.1  ELKS/Rab6-interacting/CAST family member 1 isoform X12

    8. XM_054371491.1 → XP_054227466.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

    9. XM_054371502.1 → XP_054227477.1  ELKS/Rab6-interacting/CAST family member 1 isoform X5

    10. XM_054371521.1 → XP_054227496.1  ELKS/Rab6-interacting/CAST family member 1 isoform X13

    11. XM_054371504.1 → XP_054227479.1  ELKS/Rab6-interacting/CAST family member 1 isoform X7

    12. XM_054371495.1 → XP_054227470.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

    13. XM_054371503.1 → XP_054227478.1  ELKS/Rab6-interacting/CAST family member 1 isoform X6

      UniProtKB/TrEMBL
      X6RLX0

    14. XM_054371500.1 → XP_054227475.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

    15. XM_054371508.1 → XP_054227483.1  ELKS/Rab6-interacting/CAST family member 1 isoform X8

      UniProtKB/Swiss-Prot
      A2RU77, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1

    16. XM_054371511.1 → XP_054227486.1  ELKS/Rab6-interacting/CAST family member 1 isoform X9

    17. XM_054371516.1 → XP_054227491.1  ELKS/Rab6-interacting/CAST family member 1 isoform X10

    18. XM_054371518.1 → XP_054227493.1  ELKS/Rab6-interacting/CAST family member 1 isoform X12

    19. XM_054371527.1 → XP_054227502.1  ELKS/Rab6-interacting/CAST family member 1 isoform X15

    20. XM_054371528.1 → XP_054227503.1  ELKS/Rab6-interacting/CAST family member 1 isoform X16

    21. XM_054371529.1 → XP_054227504.1  ELKS/Rab6-interacting/CAST family member 1 isoform X17

    22. XM_054371533.1 → XP_054227508.1  ELKS/Rab6-interacting/CAST family member 1 isoform X20

    23. XM_054371530.1 → XP_054227505.1  ELKS/Rab6-interacting/CAST family member 1 isoform X18

    24. XM_054371534.1 → XP_054227509.1  ELKS/Rab6-interacting/CAST family member 1 isoform X21

      UniProtKB/TrEMBL
      X6RM00

    25. XM_054371532.1 → XP_054227507.1  ELKS/Rab6-interacting/CAST family member 1 isoform X24

    26. XM_054371535.1 → XP_054227510.1  ELKS/Rab6-interacting/CAST family member 1 isoform X25

    27. XM_054371489.1 → XP_054227464.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

    28. XM_054371505.1 → XP_054227480.1  ELKS/Rab6-interacting/CAST family member 1 isoform X7

    29. XM_054371493.1 → XP_054227468.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

    30. XM_054371499.1 → XP_054227474.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

    31. XM_054371510.1 → XP_054227485.1  ELKS/Rab6-interacting/CAST family member 1 isoform X8

      UniProtKB/Swiss-Prot
      A2RU77, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1

    32. XM_054371523.1 → XP_054227498.1  ELKS/Rab6-interacting/CAST family member 1 isoform X14

    33. XM_054371512.1 → XP_054227487.1  ELKS/Rab6-interacting/CAST family member 1 isoform X9

    34. XM_054371515.1 → XP_054227490.1  ELKS/Rab6-interacting/CAST family member 1 isoform X10

    35. XM_054371519.1 → XP_054227494.1  ELKS/Rab6-interacting/CAST family member 1 isoform X12

    36. XM_054371525.1 → XP_054227500.1  ELKS/Rab6-interacting/CAST family member 1 isoform X15

    37. XM_054371490.1 → XP_054227465.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

    38. XM_054371497.1 → XP_054227472.1  ELKS/Rab6-interacting/CAST family member 1 isoform X3

    39. XM_054371506.1 → XP_054227481.1  ELKS/Rab6-interacting/CAST family member 1 isoform X7

    40. XM_054371522.1 → XP_054227497.1  ELKS/Rab6-interacting/CAST family member 1 isoform X23

    41. XM_054371494.1 → XP_054227469.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

    42. XM_054371498.1 → XP_054227473.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

    43. XM_054371524.1 → XP_054227499.1  ELKS/Rab6-interacting/CAST family member 1 isoform X14

    44. XM_054371513.1 → XP_054227488.1  ELKS/Rab6-interacting/CAST family member 1 isoform X9

    45. XM_054371517.1 → XP_054227492.1  ELKS/Rab6-interacting/CAST family member 1 isoform X10

    46. XM_054371526.1 → XP_054227501.1  ELKS/Rab6-interacting/CAST family member 1 isoform X15

    47. XM_054371531.1 → XP_054227506.1  ELKS/Rab6-interacting/CAST family member 1 isoform X19

    48. XM_054371536.1 → XP_054227511.1  ELKS/Rab6-interacting/CAST family member 1 isoform X22

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IUD2.1 GenPept UniProtKB/Swiss-Prot:Q8IUD2

    Gene LinkOut

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