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Syt1 synaptotagmin I [ Mus musculus (house mouse) ]

Gene ID: 20979, updated on 9-May-2015
Official Symbol
Syt1provided by MGI
Official Full Name
synaptotagmin Iprovided by MGI
Primary source
MGI:MGI:99667
See related
Ensembl:ENSMUSG00000035864; Vega:OTTMUSG00000016266
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SytI; AW124717; G630098F17Rik
Orthologs
See Syt1 in MapViewer
Location:
10 D1; 10 56.52 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (108497650..109010975, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (107935305..108447675, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105245279 Neighboring gene PRKC, apoptosis, WT1, regulator Neighboring gene predicted gene, 36283 Neighboring gene predicted gene, 36440 Neighboring gene predicted gene 5136 Neighboring gene predicted gene, 40756 Neighboring gene predicted gene, 40757

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SNARE binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
calcium-dependent phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
clathrin binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
syntaxin-1 binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
detection of calcium ion ISO
Inferred from Sequence Orthology
more info
 
fast, calcium ion-dependent exocytosis of neurotransmitter IDA
Inferred from Direct Assay
more info
PubMed 
fast, calcium ion-dependent exocytosis of neurotransmitter IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of regulated secretory pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle docking ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with SNARE complex ISO
Inferred from Sequence Orthology
more info
 
cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
dense core granule ISO
Inferred from Sequence Orthology
more info
 
excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule ISO
Inferred from Sequence Orthology
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle TAS
Traceable Author Statement
more info
PubMed 
synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
synaptotagmin-1
Names
synaptotagmin-1
p65
synaptotagmin 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252341.1NP_001239270.1  synaptotagmin-1 isoform 1

    See identical proteins and their annotated locations for NP_001239270.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI842617, AK078790, BC042519, BY268027, CD774438
    Consensus CDS
    CCDS24163.1
    UniProtKB/TrEMBL
    H6RXZ1
    UniProtKB/Swiss-Prot
    P46096
    Related
    ENSMUSP00000100912, OTTMUSP00000017428, ENSMUST00000105276, OTTMUST00000039005
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  2. NM_001252342.1NP_001239271.1  synaptotagmin-1 isoform 2

    See identical proteins and their annotated locations for NP_001239271.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR and uses a difference splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AI842617, AK018163, AK133578, BC042519, BY268027, CD774438
    UniProtKB/Swiss-Prot
    P46096
    Conserved Domains (2) summary
    cd08385
    Location:139261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  3. NM_009306.3NP_033332.1  synaptotagmin-1 isoform 1

    See identical proteins and their annotated locations for NP_033332.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AI842617, BC042519, BY238701, BY268027, CD774438
    Consensus CDS
    CCDS24163.1
    UniProtKB/TrEMBL
    H6RXZ1
    UniProtKB/Swiss-Prot
    P46096
    Related
    ENSMUSP00000063293, OTTMUSP00000021532, ENSMUST00000064054, OTTMUST00000047565
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    108497650..109010975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513449.1XP_006513512.1  

    See identical proteins and their annotated locations for XP_006513512.1

    Conserved Domains (2) summary
    cd08385
    Location:139261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  2. XM_006513446.1XP_006513509.1  

    See identical proteins and their annotated locations for XP_006513509.1

    UniProtKB/TrEMBL
    H6RXZ1
    UniProtKB/Swiss-Prot
    P46096
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  3. XM_006513448.1XP_006513511.1  

    See identical proteins and their annotated locations for XP_006513511.1

    UniProtKB/TrEMBL
    H6RXZ1
    UniProtKB/Swiss-Prot
    P46096
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  4. XM_006513447.1XP_006513510.1  

    See identical proteins and their annotated locations for XP_006513510.1

    UniProtKB/TrEMBL
    H6RXZ1
    UniProtKB/Swiss-Prot
    P46096
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    110438514..110956520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)