Aurkc aurora kinase C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aurkcprovided by MGI
Official Full Name: aurora kinase Cprovided by MGI
Primary source: MGI:MGI:1321119
See related: Ensembl:ENSMUSG00000070837 AllianceGenome:MGI:1321119
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AIE1; AIK3; IAK3; ARK-3; Stk13
Summary: Enables protein kinase activity. Acts upstream of or within protein autophosphorylation. Located in chromosome, centromeric region and meiotic spindle midzone. Is expressed in gonad. Human ortholog(s) of this gene implicated in spermatogenic failure 5. Orthologous to human AURKC (aurora kinase C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 2.8), ovary adult (RPKM 0.2) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 4.06 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (6998346..7006090)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (6995347..7003091)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Using ZINC08918027 inhibitor to determine Aurora kinase-chromosomal passenger complex isoforms in mouse oocytes.
Title: Using ZINC08918027 inhibitor to determine Aurora kinase-chromosomal passenger complex isoforms in mouse oocytes.
Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
Title: Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
in the absence of AURKC, AURKA localizes to chromosomes in a CPC-dependent manner. These data suggest that AURKC prevents AURKA from localizing to chromosomes by competing for CPC binding. This competition is important for adequate spindle length to support meiosis I. There is also a unique requirement for AURKB to negatively regulate AURKC to prevent aneuploidy.
Title: Genetic Interactions between the Aurora Kinases Reveal New Requirements for AURKB and AURKC during Oocyte Meiosis.
findings demonstrate that maternal RNAs regulate AURKC localization and activity in mouse oocytes
Title: Maternal RNA regulates Aurora C kinase during mouse oocyte maturation in a translation-independent fashion.
The high sequence similarity among the AURK family members has made discerning the individual kinase functions in meiosis challenging. Technical limitations in specifically targeting AURKB or AURKC using small-molecule inhibitors and compensatory abilities in single-knockout animals add to this challenge...proper regulation of AURKA expression is crucial for spindle formation in meiosis
Title: Specialize and Divide (Twice): Functions of Three Aurora Kinase Homologs in Mammalian Oocyte Meiotic Maturation.
Three of these mutations AURKC c.144delC (AURKC p.L49Wfs22), AURKC c.686G > A (AURKC p.C229Y) and AURKC c.744C > G (AURKC p.Y248*) are the focus of this study. AURKC p.L49Wfs22 is a loss-of-function mutant that perturbs localization of the chromosomal passenger complex (CPC), AURKC p.C229Y is a hypomorph that cannot fully support cell-cycle progression, and AURKC p.Y248* fails to support chromosome segregation.
Title: Characterization of macrozoospermia-associated AURKC mutations in a mammalian meiotic system.
These data uncover a role for haspin as a regulator of bipolar spindle assembly by regulating AURKC function at acentriolar microtubule-organizing centers in oocytes.
Title: Haspin kinase regulates microtubule-organizing center clustering and stability through Aurora kinase C in mouse oocytes.
these data suggest that mammalian oocytes contain AURKC to efficiently execute meiosis I and ensure high-quality eggs necessary for sexual reproduction.
Title: Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes.
These findings suggest a model for the presence of AURKC in oocytes: that AURKC compensates for loss of AURKB through differences in both message recruitment and protein stability.
Title: Maternally recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development.
overexpression of Aurora-C induces abnormal cell division resulting in centrosome amplification and multinucleation; tumor aggressiveness was positively correlated with the quantity of active kinase
Title: Overexpression of active Aurora-C kinase results in cell transformation and tumour formation.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

Aurkc (e-PCR), detects polymorphism
- UniSTS:546548

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in meiotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle midzone	ISO Inferred from Sequence Orthology more info
is_active_in spindle pole centrosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aurora kinase C

Names: aurora 3; aurora B; aurora-related kinase 3; aurora/IPL1-related kinase 3; aurora/Ipl1/Eg2 protein 1; serine/threonine kinase 13 (aurora/IPL-like); serine/threonine-protein kinase 13; serine/threonine-protein kinase aurora-C

NP_001074434.2

EC 2.7.11.1

NP_001074435.1

EC 2.7.11.1

NP_065597.2

EC 2.7.11.1

XP_006539760.1

EC 2.7.11.1

XP_006539764.1

EC 2.7.11.1

XP_017177568.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080965.2 → NP_001074434.2 aurora kinase C

Status: VALIDATED

Source sequence(s)

AC152418

UniProtKB/Swiss-Prot

O88445, Q6P209, Q9JLC2

Related

ENSMUSP00000083426.7, ENSMUST00000086248.8
NM_001080966.2 → NP_001074435.1 aurora kinase C

See identical proteins and their annotated locations for NP_001074435.1

Status: VALIDATED

Source sequence(s)

AC152418

Consensus CDS

CCDS85211.1

UniProtKB/Swiss-Prot

O88445, Q6P209, Q9JLC2

UniProtKB/TrEMBL

Q497X5

Related

ENSMUSP00000146450.2, ENSMUST00000207711.2

Conserved Domains (1) summary

cl21453
Location:9 → 275

PKc_like; Protein Kinases, catalytic domain
NM_020572.3 → NP_065597.2 aurora kinase C

See identical proteins and their annotated locations for NP_065597.2

Status: VALIDATED

Source sequence(s)

AC152418

Consensus CDS

CCDS85211.1

UniProtKB/Swiss-Prot

O88445, Q6P209, Q9JLC2

UniProtKB/TrEMBL

Q497X5

Related

ENSMUSP00000147207.2, ENSMUST00000208049.2

Conserved Domains (1) summary

cl21453
Location:9 → 275

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

6998346..7006090

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017322079.1 → XP_017177568.1 aurora kinase C isoform X1

UniProtKB/Swiss-Prot

O88445, Q6P209, Q9JLC2

UniProtKB/TrEMBL

Q497X5

Conserved Domains (1) summary

cl21453
Location:9 → 275

PKc_like; Protein Kinases, catalytic domain
XM_006539697.3 → XP_006539760.1 aurora kinase C isoform X1

See identical proteins and their annotated locations for XP_006539760.1

UniProtKB/Swiss-Prot

O88445, Q6P209, Q9JLC2

UniProtKB/TrEMBL

Q497X5

Conserved Domains (1) summary

cl21453
Location:9 → 275

PKc_like; Protein Kinases, catalytic domain
XM_006539701.3 → XP_006539764.1 aurora kinase C isoform X1

See identical proteins and their annotated locations for XP_006539764.1

UniProtKB/Swiss-Prot

O88445, Q6P209, Q9JLC2

UniProtKB/TrEMBL

Q497X5

Conserved Domains (1) summary

cl21453
Location:9 → 275

PKc_like; Protein Kinases, catalytic domain