U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Dusp8 dual specificity phosphatase 8 [ Mus musculus (house mouse) ]

    Gene ID: 18218, updated on 21-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dusp8provided by MGI
    Official Full Name
    dual specificity phosphatase 8provided by MGI
    Primary source
    MGI:MGI:106626
    See related
    Ensembl:ENSMUSG00000037887 AllianceGenome:MGI:106626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nttp1; 5530400B01Rik
    Summary
    Enables phosphatase activity. Involved in dephosphorylation. Predicted to be located in nucleus. Predicted to be active in cytosol. Is expressed in several structures, including blood vessel; central nervous system; placenta; retina; and yolk sac. Orthologous to human DUSP8 (dual specificity phosphatase 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in whole brain E14.5 (RPKM 20.5), CNS E18 (RPKM 19.5) and 22 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    7 F5; 7 87.59 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141633224..141649799, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142079487..142095907, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20498 Neighboring gene MOB kinase activator 2 Neighboring gene predicted gene, 25416 Neighboring gene predicted gene, 57785 Neighboring gene predicted gene 45417 Neighboring gene predicted gene, 32786 Neighboring gene keratin associated protein 5-26

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Dusp8 affects hippocampal size and behavior in mice and humans. Baumann P, et al. Sci Rep, 2019 Dec 20. PMID 31862894, Free PMC Article
    2. DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling. Liu R, et al. Circ Res, 2016 Jul 8. PMID 27225478, Free PMC Article
    3. Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans. Baumann P, et al. Brain Behav, 2021 Jan. PMID 33131190, Free PMC Article
    4. A member of the MAP kinase phosphatase gene family in mouse containing a complex trinucleotide repeat in the coding region. Theodosiou AM, et al. Hum Mol Genet, 1996 May. PMID 8733137
    5. hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase. Martell KJ, et al. J Neurochem, 1995 Oct. PMID 7561881

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DUSP8 induces TGF-beta-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-alpha.
      Title: DUSP8 induces TGF-β-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-α.
    2. Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration.
      Title: Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration.
    3. Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.
      Title: Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.
    4. Mice lacking DUSP6/8 have enhanced ERK1/2 activity and resistance to diet-induced obesity.
      Title: Mice lacking DUSP6/8 have enhanced ERK1/2 activity and resistance to diet-induced obesity.
    5. Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
      Title: Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
    6. DUSP8 controls stress-induced ERK1/2 signaling in cardiac myocytes.
      Title: DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    dual specificity protein phosphatase 8
    Names
    neuronal tyrosine threonine phosphatase 1
    NP_032774.1
    XP_006508572.1
    XP_011240291.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008748.3 → NP_032774.1  dual specificity protein phosphatase 8

      See identical proteins and their annotated locations for NP_032774.1

      Status: VALIDATED

      Source sequence(s)
      AL603836, BC052705, BQ043453
      Consensus CDS
      CCDS22024.1
      UniProtKB/Swiss-Prot
      O09112
      UniProtKB/TrEMBL
      Q7TSZ9
      Related
      ENSMUSP00000049414.4, ENSMUST00000039926.10
      Conserved Domains (2) summary
      cd01446
      Location:10 → 137
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cd14645
      Location:150 → 300
      DSP_DUSP8; dual specificity phosphatase domain of dual specificity protein phosphatase 8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141633224..141649799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241989.4 → XP_011240291.1  dual specificity protein phosphatase 8 isoform X1

      See identical proteins and their annotated locations for XP_011240291.1

      UniProtKB/Swiss-Prot
      O09112
      UniProtKB/TrEMBL
      Q7TSZ9
      Conserved Domains (2) summary
      cd01446
      Location:10 → 137
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cd14645
      Location:150 → 300
      DSP_DUSP8; dual specificity phosphatase domain of dual specificity protein phosphatase 8

    2. XM_006508509.5 → XP_006508572.1  dual specificity protein phosphatase 8 isoform X1

      See identical proteins and their annotated locations for XP_006508572.1

      UniProtKB/Swiss-Prot
      O09112
      UniProtKB/TrEMBL
      Q7TSZ9
      Conserved Domains (2) summary
      cd01446
      Location:10 → 137
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cd14645
      Location:150 → 300
      DSP_DUSP8; dual specificity phosphatase domain of dual specificity protein phosphatase 8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O09112.1 GenPept UniProtKB/Swiss-Prot:O09112

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous