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    rpa-2 Replication protein A C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172092, updated on 23-Nov-2023

    Summary

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    Gene symbol
    rpa-2
    Gene description
    Replication protein A C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00019767
    Locus tag
    CELE_M04F3.1
    See related
    AllianceGenome:WB:WBGene00019767
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables enzyme binding activity. Involved in positive regulation of helicase activity. Predicted to be part of DNA replication factor A complex. Predicted to be active in chromosome, telomeric region; nucleus; and site of double-strand break. Is expressed in intestine; pharyngeal neurons; and seam cell. Orthologous to several human genes including RPA2 (replication protein A2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (4770292..4771358)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein Neighboring gene IMD domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RPA complexes in Caenorhabditis elegans meiosis; unique roles in replication, meiotic recombination and apoptosis. Hefel A, et al. Nucleic Acids Res, 2021 Feb 26. PMID 33476370, Free PMC Article
    2. Physical and functional interactions of Caenorhabditis elegans WRN-1 helicase with RPA-1. Hyun M, et al. Biochemistry, 2012 Feb 21. PMID 22257160
    3. Biochemical characterization of the WRN-1 RecQ helicase of Caenorhabditis elegans. Hyun M, et al. Biochemistry, 2008 Jul 15. PMID 18558712, Free PMC Article
    4. Enzymatic properties of the Caenorhabditis elegans Dna2 endonuclease/helicase and a species-specific interaction between RPA and Dna2. Kim DH, et al. Nucleic Acids Res, 2005. PMID 15745997, Free PMC Article
    5. RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair. Martin JS, et al. Mol Cell Biol, 2005 Apr. PMID 15798199, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RPA complexes in Caenorhabditis elegans meiosis; unique roles in replication, meiotic recombination and apoptosis.
      Title: RPA complexes in Caenorhabditis elegans meiosis; unique roles in replication, meiotic recombination and apoptosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA replication factor A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA replication factor A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Replication protein A C-terminal domain-containing protein
    NP_491446.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4770292..4771358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059045.8 → NP_491446.1  Replication protein A C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491446.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Y97
      Conserved Domains (2) summary
      COG5235
      Location:42 → 282
      RFA2; Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit [DNA replication, recombination, and repair]
      cd04478
      Location:68 → 163
      RPA2_DBD_D; A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
    Nucleotide Protein
    Heading Accession and Version

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