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    DECR1 2,4-dienoyl CoA reductase 1, mitochondrial [ Homo sapiens (human) ]

    Gene ID: 1666, updated on 5-Jul-2015
    Official Symbol
    DECR1provided by HGNC
    Official Full Name
    2,4-dienoyl CoA reductase 1, mitochondrialprovided by HGNC
    Primary source
    HGNC:HGNC:2753
    See related
    Ensembl:ENSG00000104325; HPRD:01959; MIM:222745; Vega:OTTHUMG00000163829
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DECR; NADPH; SDR18C1
    Summary
    This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq, Jul 2008]
    Orthologs
    See DECR1 in Epigenomics, MapViewer
    Location:
    8q21.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (90001352..90052004)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (91013580..91064232)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene oxidative stress induced growth inhibitor family member 2 Neighboring gene nibrin Neighboring gene calbindin 1, 28kDa Neighboring gene long intergenic non-protein coding RNA 534 Neighboring gene uncharacterized LOC101926899

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    2,4-dienoyl-CoA reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NADPH binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidoreductase activity, acting on NAD(P)H TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    cellular lipid metabolic process TAS
    Traceable Author Statement
    more info
     
    fatty acid beta-oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fatty acid beta-oxidation TAS
    Traceable Author Statement
    more info
     
    protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    2,4-dienoyl-CoA reductase, mitochondrial
    Names
    4-enoyl-CoA reductase
    short chain dehydrogenase/reductase family 18C member 1
    short chain dehydrogenase/reductase family 18C, member 1
    NP_001350.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008042.1 RefSeqGene

      Range
      5001..55648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001359.1NP_001350.1  2,4-dienoyl-CoA reductase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001350.1

      Status: REVIEWED

      Source sequence(s)
      AF049895
      Consensus CDS
      CCDS6250.1
      UniProtKB/TrEMBL
      A0A024R9D7
      UniProtKB/Swiss-Prot
      Q16698
      Related
      ENSP00000220764, OTTHUMP00000225076, ENST00000220764, OTTHUMT00000375822
      Conserved Domains (2) summary
      cd05369
      Location:57303
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
      PRK07576
      Location:57302
      PRK07576; short chain dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

      Range
      90001352..90052004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005250808.3XP_005250865.1  

      Conserved Domains (1) summary
      cd05369
      Location:1211
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
    2. XM_011516880.1XP_011515182.1  

      Conserved Domains (2) summary
      cd05369
      Location:48294
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
      PRK07576
      Location:48293
      PRK07576; short chain dehydrogenase; Provisional

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      91054504..91105151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)