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DECR1 2,4-dienoyl CoA reductase 1, mitochondrial [ Homo sapiens (human) ]

Gene ID: 1666, updated on 27-Sep-2014
Official Symbol
DECR1provided by HGNC
Official Full Name
2,4-dienoyl CoA reductase 1, mitochondrialprovided by HGNC
Primary source
HGNC:HGNC:2753
See related
Ensembl:ENSG00000104325; HPRD:01959; MIM:222745; Vega:OTTHUMG00000163829
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DECR; NADPH; SDR18C1
Summary
This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq, Jul 2008]
See DECR1 in Epigenomics, MapViewer
Location:
8q21.3
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 8 NC_000008.11 (90001352..90052004)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (91013580..91064232)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene oxidative stress induced growth inhibitor family member 2 Neighboring gene nibrin Neighboring gene calbindin 1, 28kDa Neighboring gene long intergenic non-protein coding RNA 534 Neighboring gene uncharacterized LOC101926899

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
2,4-dienoyl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
NADPH binding IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity, acting on NAD(P)H TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cellular lipid metabolic process TAS
Traceable Author Statement
more info
 
fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid beta-oxidation TAS
Traceable Author Statement
more info
 
protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
2,4-dienoyl-CoA reductase, mitochondrial
Names
2,4-dienoyl-CoA reductase, mitochondrial
4-enoyl-CoA reductase
short chain dehydrogenase/reductase family 18C, member 1
NP_001350.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008042.1 

    Range
    5001..55648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001359.1NP_001350.1  2,4-dienoyl-CoA reductase, mitochondrial precursor

    See proteins identical to NP_001350.1

    Status: REVIEWED

    Source sequence(s)
    AF049895
    Consensus CDS
    CCDS6250.1
    UniProtKB/TrEMBL
    A0A024R9D7
    UniProtKB/Swiss-Prot
    Q16698
    Related
    ENSP00000220764, OTTHUMP00000225076, ENST00000220764, OTTHUMT00000375822
    Conserved Domains (2) summary
    cd05369
    Location:57303
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
    PRK07576
    Location:57302
    PRK07576; short chain dehydrogenase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11 

    Range
    90001352..90052004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250808.2XP_005250865.1  

    Conserved Domains (1) summary
    cd05369
    Location:1211
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

Alternate HuRef

Genomic

  1. AC_000140.1 

    Range
    86223894..86274542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 

    Range
    91054504..91105151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)