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    Il2 interleukin 2 [ Mus musculus (house mouse) ]

    Gene ID: 16183, updated on 25-Aug-2016
    Official Symbol
    Il2provided by MGI
    Official Full Name
    interleukin 2provided by MGI
    Primary source
    MGI:MGI:96548
    See related
    Ensembl:ENSMUSG00000027720 Vega:OTTMUSG00000007347
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il-2
    Orthologs
    Location:
    3 18.3 cM; 3 B-C
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (37120713..37125954, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (37019635..37024876, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene adenosine deaminase domain containing 1 (testis specific) Neighboring gene zinc finger, CCHC domain containing 17 pseudogene Neighboring gene nucleophosmin 1 pseudogene Neighboring gene predicted gene, 36000 Neighboring gene predicted gene 12532

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    glycosphingolipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-2 receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-2 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    kappa-type opioid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to biotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of B cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of lymphocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of B cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of activated T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of immunoglobulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-gamma production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-17 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of isotype switching to IgG isotypes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of Stat5 protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of Stat5 protein ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of T cell homeostatic proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    interleukin-2
    Names
    T-cell growth factor
    TCGF

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008366.3NP_032392.1  interleukin-2 precursor

      See identical proteins and their annotated locations for NP_032392.1

      Status: VALIDATED

      Source sequence(s)
      BX519775, K02292
      Consensus CDS
      CCDS17316.1
      UniProtKB/Swiss-Prot
      P04351
      Related
      ENSMUSP00000029275, OTTMUSP00000007837, ENSMUST00000029275, OTTMUST00000016996
      Conserved Domains (1) summary
      smart00189
      Location:1168
      IL2; Interleukin-2 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      37120713..37125954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 129S1/SvImJ

    Genomic

    1. NT_039248.1 Reference GRCm38.p4 129S1/SvImJ

      Range
      20415..25649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_039252.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      61342..66576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)