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    Gpr162 G protein-coupled receptor 162 [ Mus musculus (house mouse) ]

    Gene ID: 14788, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Gpr162provided by MGI
    Official Full Name
    G protein-coupled receptor 162provided by MGI
    Primary source
    MGI:MGI:1315214
    See related
    Ensembl:ENSMUSG00000038390 AllianceGenome:MGI:1315214
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A-2; Grca
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in gut; nervous system; and neural retina. Orthologous to human GPR162 (G protein-coupled receptor 162). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 36.3), cerebellum adult (RPKM 34.6) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 F2; 6 59.17 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124835407..124840900, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124858444..124864195, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), beta 3 Neighboring gene STARR-positive B cell enhancer ABC_E6487 Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124812982-124813183 Neighboring gene predicted gene, 32404 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124814119-124814302 Neighboring gene CD4 antigen Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124829493-124829732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124836126-124836313 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124850419-124850700 Neighboring gene STARR-positive B cell enhancer ABC_E4863 Neighboring gene STARR-positive B cell enhancer ABC_E1710 Neighboring gene lymphocyte-activation gene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The G protein-coupled receptor GPR162 is widely distributed in the CNS and highly expressed in the hypothalamus and in hedonic feeding areas. Caruso V, et al. Gene, 2014 Dec 10. PMID 25275856
    2. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Gloriam DE, et al. Biochim Biophys Acta, 2005 Apr 15. PMID 15777626
    3. Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Ansari-Lari MA, et al. Genome Res, 1998 Jan. PMID 9445485
    4. A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells. Shah K, et al. J Mol Cell Biol, 2020 Jan 22. PMID 31065682, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 162
    Names
    gene rich cluster, A
    NP_001342186.1
    NP_001396767.1
    NP_001396768.1
    NP_001396769.1
    NP_001396770.1
    NP_001396772.1
    NP_038561.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355257.2 → NP_001342186.1  probable G-protein coupled receptor 162 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC142254
      Consensus CDS
      CCDS20534.1
      UniProtKB/Swiss-Prot
      O88835, Q3UN16
      Related
      ENSMUSP00000145267.2, ENSMUST00000204667.2
      Conserved Domains (1) summary
      cd15906
      Location:14 → 335
      7tmA_GPR162; G protein-coupled receptor 162, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001409838.1 → NP_001396767.1  probable G-protein coupled receptor 162 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC142254
      UniProtKB/Swiss-Prot
      O88835, Q3UN16

    3. NM_001409839.1 → NP_001396768.1  probable G-protein coupled receptor 162 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC142254
      UniProtKB/Swiss-Prot
      O88835, Q3UN16

    4. NM_001409840.1 → NP_001396769.1  probable G-protein coupled receptor 162 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the longest transcript and encodes the longer isoform (a). Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AC142254
      UniProtKB/Swiss-Prot
      O88835, Q3UN16

    5. NM_001409841.1 → NP_001396770.1  probable G-protein coupled receptor 162 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC142254

    6. NM_001409843.1 → NP_001396772.1  probable G-protein coupled receptor 162 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC142254

    7. NM_013533.5 → NP_038561.1  probable G-protein coupled receptor 162 isoform a

      See identical proteins and their annotated locations for NP_038561.1

      Status: VALIDATED

      Source sequence(s)
      AC142254
      Consensus CDS
      CCDS20534.1
      UniProtKB/Swiss-Prot
      O88835, Q3UN16
      Related
      ENSMUSP00000038536.8, ENSMUST00000046893.10
      Conserved Domains (1) summary
      cd15906
      Location:14 → 335
      7tmA_GPR162; G protein-coupled receptor 162, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      124835407..124840900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UN16.2 GenPept UniProtKB/Swiss-Prot:Q3UN16

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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