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ADORA1 adenosine A1 receptor [ Homo sapiens (human) ]

Gene ID: 134, updated on 6-Jul-2014
Official Symbol
ADORA1provided by HGNC
Official Full Name
adenosine A1 receptorprovided by HGNC
Primary source
HGNC:262
See related
Ensembl:ENSG00000163485; HPRD:00042; MIM:102775; Vega:OTTHUMG00000042125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RDC7
Summary
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
See ADORA1 in Epigenomics, MapViewer
Location:
1q32.1
Exon count :
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (203127705..203167405)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (203096833..203136533)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 Neighboring gene myogenin (myogenic factor 4) Neighboring gene myosin binding protein H Neighboring gene chitinase 3-like 1 (cartilage glycoprotein-39)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adenosine P1 receptors, organism-specific biosystem (from REACTOME)
    Adenosine P1 receptors, organism-specific biosystemThe adenosine receptors (P1 receptors) are a class of purinergic receptors, G-protein coupled receptors with adenosine as their endogenous ligand.In humans, there are four adenosine receptors. Each i...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Morphine addiction, organism-specific biosystem (from KEGG)
    Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Morphine addiction, conserved biosystem (from KEGG)
    Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Nucleotide GPCRs, organism-specific biosystem (from WikiPathways)
    Nucleotide GPCRs, organism-specific biosystem
    Nucleotide GPCRs
  • Nucleotide-like (purinergic) receptors, organism-specific biosystem (from REACTOME)
    Nucleotide-like (purinergic) receptors, organism-specific biosystemPurinergic receptors (Burnstock G, 2006; Abbracchio MP et al, 2009) are a family of newly characterized plasma membrane molecules involved in several cellular functions such as vascular reactivity, a...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
 
G-protein coupled adenosine receptor activity IEA
Inferred from Electronic Annotation
more info
 
G-protein coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 
heterotrimeric G-protein binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
purine nucleoside binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of MAPKK activity IEA
Inferred from Electronic Annotation
more info
 
adenosine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cognition IEA
Inferred from Electronic Annotation
more info
 
detection of temperature stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of circadian sleep/wake cycle, non-REM sleep IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of heart contraction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hormone secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of leukocyte migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mucus secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neurotrophin production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of renal sodium excretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
negative regulation of vasodilation IEA
Inferred from Electronic Annotation
more info
 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
phagocytosis TAS
Traceable Author Statement
more info
PubMed 
positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nucleoside transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptide secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
 
regulation of excitatory postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
regulation of glomerular filtration IEA
Inferred from Electronic Annotation
more info
 
regulation of respiratory gaseous exchange by neurological system process IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
relaxation of vascular smooth muscle IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
temperature homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
asymmetric synapse IEA
Inferred from Electronic Annotation
more info
 
axolemma IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 
presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
terminal bouton IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
adenosine receptor A1
Names
adenosine receptor A1
adenosine A1 receptor variant 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000674.2NP_000665.1  adenosine receptor A1

    See proteins identical to NP_000665.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC105940, BU740906, DB171678, L22214
    Consensus CDS
    CCDS1434.1
    UniProtKB/Swiss-Prot
    P30542
    Related
    ENSP00000338435, ENST00000337894
    Conserved Domains (2) summary
    pfam00001
    Location:32288
    Blast Score: 336
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10320
    Location:20116
    Blast Score: 92
    7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx
  2. NM_001048230.1NP_001041695.1  adenosine receptor A1

    See proteins identical to NP_001041695.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing one of the 5' non-coding exons, and thus has a shorter 5' UTR compared to transcript variant 1. Both variants encode the same protein.
    Source sequence(s)
    AC105940, AK127752, BU740906, DA343445
    Consensus CDS
    CCDS1434.1
    UniProtKB/Swiss-Prot
    P30542
    Related
    ENSP00000356205, OTTHUMP00000039090, ENST00000367236, OTTHUMT00000100273
    Conserved Domains (2) summary
    pfam00001
    Location:32288
    Blast Score: 336
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10320
    Location:20116
    Blast Score: 92
    7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    203127705..203167405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005244901.1XP_005244958.1  

    See proteins identical to XP_005244958.1

    UniProtKB/TrEMBL
    B7Z1L9
    Conserved Domains (1) summary
    pfam00001
    Location:46220
    Blast Score: 193
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_005244899.1XP_005244956.1  

    See proteins identical to XP_005244956.1

    UniProtKB/TrEMBL
    B7Z379
    Conserved Domains (2) summary
    pfam00001
    Location:65321
    Blast Score: 343
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10320
    Location:53149
    Blast Score: 96
    7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx
  3. XM_005244902.2XP_005244959.1  

    See proteins identical to XP_005244959.1

    UniProtKB/TrEMBL
    B7Z1L9
    Conserved Domains (1) summary
    pfam00001
    Location:46220
    Blast Score: 193
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    174262408..174301662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    204519171..204558852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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