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    ADORA1 adenosine A1 receptor [ Homo sapiens (human) ]

    Gene ID: 134, updated on 26-Jul-2015
    Official Symbol
    ADORA1provided by HGNC
    Official Full Name
    adenosine A1 receptorprovided by HGNC
    Primary source
    HGNC:HGNC:262
    See related
    Ensembl:ENSG00000163485; HPRD:00042; MIM:102775; Vega:OTTHUMG00000042125
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RDC7
    Summary
    The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    See ADORA1 in Epigenomics, MapViewer
    Location:
    1q32.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (203127705..203167405)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (203096833..203136533)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 Neighboring gene uncharacterized LOC105371687 Neighboring gene myogenin (myogenic factor 4) Neighboring gene myosin binding protein H Neighboring gene chitinase 3-like 1 (cartilage glycoprotein-39)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
    NHGRI GWA Catalog
    • Adenosine P1 receptors, organism-specific biosystem (from REACTOME)
      Adenosine P1 receptors, organism-specific biosystemThe adenosine receptors (P1 receptors) are a class of purinergic receptors, G-protein coupled receptors with adenosine as their endogenous ligand.In humans, there are four adenosine receptors. Each i...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • Morphine addiction, organism-specific biosystem (from KEGG)
      Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Morphine addiction, conserved biosystem (from KEGG)
      Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Nucleotide GPCRs, organism-specific biosystem (from WikiPathways)
      Nucleotide GPCRs, organism-specific biosystem
      Nucleotide GPCRs
    • Nucleotide-like (purinergic) receptors, organism-specific biosystem (from REACTOME)
      Nucleotide-like (purinergic) receptors, organism-specific biosystemPurinergic receptors (Burnstock G, 2006; Abbracchio MP et al, 2009) are a family of newly characterized plasma membrane molecules involved in several cellular functions such as vascular reactivity, a...
    • Regulation of lipolysis in adipocytes, organism-specific biosystem (from KEGG)
      Regulation of lipolysis in adipocytes, organism-specific biosystemLipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. ...
    • Renin secretion, organism-specific biosystem (from KEGG)
      Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Renin secretion, conserved biosystem (from KEGG)
      Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Sphingolipid signaling pathway, organism-specific biosystem (from KEGG)
      Sphingolipid signaling pathway, organism-specific biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
    • Sphingolipid signaling pathway, conserved biosystem (from KEGG)
      Sphingolipid signaling pathway, conserved biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    G-protein coupled adenosine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    G-protein coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    heterotrimeric G-protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    purine nucleoside binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    activation of MAPKK activity IEA
    Inferred from Electronic Annotation
    more info
     
    adenosine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    cognition IEA
    Inferred from Electronic Annotation
    more info
     
    detection of temperature stimulus involved in sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of acute inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of circadian sleep/wake cycle, non-REM sleep IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of glutamate secretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of long term synaptic depression IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mucus secretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neurotrophin production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of renal sodium excretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of vasodilation IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    phagocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epidermal growth factor-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nucleoside transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptide secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of glomerular filtration IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of respiratory gaseous exchange by neurological system process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    relaxation of vascular smooth muscle IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    temperature homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    asymmetric synapse IEA
    Inferred from Electronic Annotation
    more info
     
    axolemma IEA
    Inferred from Electronic Annotation
    more info
     
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
     
    presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    adenosine receptor A1
    Names
    adenosine A1 receptor variant 1
    adenosine A1 receptor variant 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000674.2NP_000665.1  adenosine receptor A1

      See identical proteins and their annotated locations for NP_000665.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC105940, BU740906, DB171678, L22214
      Consensus CDS
      CCDS1434.1
      UniProtKB/Swiss-Prot
      P30542
      Related
      ENSP00000338435, ENST00000337894
      Conserved Domains (2) summary
      pfam00001
      Location:32288
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:20116
      7tm_4; Olfactory receptor
    2. NM_001048230.1NP_001041695.1  adenosine receptor A1

      See identical proteins and their annotated locations for NP_001041695.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing one of the 5' non-coding exons, and thus has a shorter 5' UTR compared to transcript variant 1. Both variants encode the same protein.
      Source sequence(s)
      AC105940, AK127752, BU740906, DA343445
      Consensus CDS
      CCDS1434.1
      UniProtKB/Swiss-Prot
      P30542
      Related
      ENSP00000356205, OTTHUMP00000039090, ENST00000367236, OTTHUMT00000100273
      Conserved Domains (2) summary
      pfam00001
      Location:32288
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:20116
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

      Range
      203127705..203167405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509203.1XP_011507505.1  

      See identical proteins and their annotated locations for XP_011507505.1

      UniProtKB/TrEMBL
      A0A087X173
      Conserved Domains (1) summary
      pfam00001
      Location:2172
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. XM_005244901.1XP_005244958.1  

      See identical proteins and their annotated locations for XP_005244958.1

      UniProtKB/TrEMBL
      B7Z1L9
      Conserved Domains (1) summary
      pfam00001
      Location:46220
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    3. XM_011509204.1XP_011507506.1  

      See identical proteins and their annotated locations for XP_011507506.1

      UniProtKB/TrEMBL
      A0A087X173
      Conserved Domains (1) summary
      pfam00001
      Location:2172
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    4. XM_005244902.3XP_005244959.1  

      See identical proteins and their annotated locations for XP_005244959.1

      UniProtKB/TrEMBL
      B7Z1L9
      Conserved Domains (1) summary
      pfam00001
      Location:46220
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      204519171..204558852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)