ADORA1 adenosine A1 receptor [Homo sapiens (human)] - Gene

Summary

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Official Symbol: ADORA1provided by HGNC
Official Full Name: adenosine A1 receptorprovided by HGNC
Primary source: HGNC:262
See related: Ensembl:ENSG00000163485; HPRD:00042; MIM:102775; Vega:OTTHUMG00000042125
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RDC7
Summary: The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 1q32.1

Sequence :: Chromosome: 1; NC_000001.10 (203096836..203136533)

See ADORA1 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

ADA open form, but not the closed one, that is responsible for the functional interaction with AR and AAR.
Title: The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors.
Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway
Title: Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
A1/A2 adenosine receptor activation does not directly contribute to cutaneous active vasodilatation.
Title: No direct role for A1/A2 adenosine receptor activation to reflex cutaneous vasodilatation during whole-body heat stress in humans.
A(1) and A(2B)ARs could be potential biomarkers able to provide an early indication of SA risk and their stimulation may turn out to improve fetoplacental perfusion by increasing vascular endothelial growth factor (VEGF) and nitric oxide (NO).
Title: Downregulation of A(1) and A(2B) adenosine receptors in human trisomy 21 mesenchymal cells from first-trimester chorionic villi.
In patients with stable angina ADORA1 agonist capadenoson lowers exercise heart at comparable maximum workload, which is associated with improved total exercise time and prolongation of time to ischaemia.
Title: The new oral adenosine A1 receptor agonist capadenoson in male patients with stable angina.
Results indicate a role for adenosine receptor A1 and A2A gene polymorphisms in susceptibility to apnoea of prematurity and bronchopulmonary dysplasia and in interindividual variability to caffeine response.
Title: Genetic basis of apnoea of prematurity and caffeine treatment response: role of adenosine receptor polymorphisms: genetic basis of apnoea of prematurity.
Data suggest that expression of ADORA1 is too low to play a major role in regulation of lipogenic gene expression in hepatocytes; studies include investigation of gene expression under influence of ADORA1 agonists.
Title: Adenosine A₁ receptors do not play a major role in the regulation of lipogenic gene expression in hepatocytes.
data show that expression of A1Rs induced adipocyte differentiation, whereas A2bR expression inhibited adipogenesis and stimulated an osteoblastic phenotype
Title: Contrasting effects of A1 and A2b adenosine receptors on adipogenesis.
AMP and a non-hydrolyzable AMP analog (deoxyadenosine 5'-monophosphonate, ACP) directly activated the adenosine A(1) receptor
Title: AMP is an adenosine A1 receptor agonist.
Inhibition of human mast cell activation would be a mechanism for A AR antagonists, but not A(2B) AR antagonists.
Title: Reciprocal modulation of anti-IgE induced histamine release from human mast cells by A₁ and A(2B) adenosine receptors.

Submit: New GeneRIF Correction See all (53)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
P30542	P00813	ADA	HPRD	PubMed
P30542	P21728	DRD1	HPRD	PubMed
P30542	O43491	EPB41L2	HPRD	PubMed
P30542	P04899	GNAI2	HPRD	PubMed
P30542	P09471	GNAO1	HPRD	PubMed
P30542	Q5JWF2	GNAS	HPRD	PubMed
P30542	P19086	GNAZ	HPRD	PubMed
P30542	Q13255	GRM1	HPRD	PubMed
P30542	P47900	P2RY1	HPRD	PubMed
BioGRID:106646	BioGRID:106614	ADA	BioGRID	PubMed	Co-localization
BioGRID:106646	BioGRID:131172	ATXN1L	BioGRID	PubMed	Two-hybrid
BioGRID:106646	BioGRID:108146	DRD1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106646	BioGRID:109033	GNAI2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106646	BioGRID:109168	GRM1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106646	BioGRID:111067	P2RY1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106646	BioGRID:116425	SNF8	BioGRID	PubMed	Two-hybrid

Pathways from BioSystems

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Adenosine P1 receptors, organism-specific biosystem (from REACTOME)
Adenosine P1 receptors, organism-specific biosystemThe adenosine receptors (P1 receptors) are a class of purinergic receptors, G-protein coupled receptors with adenosine as their endogenous ligand.In humans, there are four adenosine receptors. Each i...
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
Morphine addiction, organism-specific biosystem (from KEGG)
Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
Morphine addiction, conserved biosystem (from KEGG)
Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
Neuroactive ligand-receptor interaction, organism-specific biosystem
Neuroactive ligand-receptor interaction
Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
Neuroactive ligand-receptor interaction, conserved biosystem
Neuroactive ligand-receptor interaction
Nucleotide GPCRs, organism-specific biosystem (from WikiPathways)
Nucleotide GPCRs, organism-specific biosystem
Nucleotide GPCRs
Nucleotide-like (purinergic) receptors, organism-specific biosystem (from REACTOME)
Nucleotide-like (purinergic) receptors, organism-specific biosystemPurinergic receptors (Burnstock G, 2006; Abbracchio MP et al, 2009) are a family of newly characterized plasma membrane molecules involved in several cellular functions such as vascular reactivity, a...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

General gene information

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Markers

SHGC-76157 (e-PCR)
- UniSTS:59052

D1S1699 (e-PCR)
- UniSTS:12997

GDB:452605 (e-PCR)
- UniSTS:157389

Homology

Homologs of the ADORA1 gene: The ADORA1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
G-protein coupled adenosine receptor activity	IEA Inferred from Electronic Annotation more info
G-protein coupled receptor binding	IEA Inferred from Electronic Annotation more info
heterotrimeric G-protein binding	IEA Inferred from Electronic Annotation more info
phospholipase C activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
purine nucleoside binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
activation of MAPKK activity	IEA Inferred from Electronic Annotation more info
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
apoptotic signaling pathway	TAS Traceable Author Statement more info	PubMed
cell-cell signaling	TAS Traceable Author Statement more info	PubMed
cognition	IEA Inferred from Electronic Annotation more info
detection of temperature stimulus involved in sensory perception of pain	IEA Inferred from Electronic Annotation more info
inflammatory response	TAS Traceable Author Statement more info	PubMed
lipid catabolic process	IEA Inferred from Electronic Annotation more info
negative regulation of acute inflammatory response	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of blood pressure	IEA Inferred from Electronic Annotation more info
negative regulation of cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of circadian sleep/wake cycle, non-REM sleep	IEA Inferred from Electronic Annotation more info
negative regulation of glutamate secretion	IEA Inferred from Electronic Annotation more info
negative regulation of heart contraction	IEA Inferred from Electronic Annotation more info
negative regulation of hormone secretion	IEA Inferred from Electronic Annotation more info
negative regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info
negative regulation of lipid catabolic process	IEA Inferred from Electronic Annotation more info
negative regulation of mucus secretion	IEA Inferred from Electronic Annotation more info
negative regulation of neurotrophin production	IEA Inferred from Electronic Annotation more info
negative regulation of renal sodium excretion	IEA Inferred from Electronic Annotation more info
negative regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
negative regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
negative regulation of vasodilation	IEA Inferred from Electronic Annotation more info
nervous system development	TAS Traceable Author Statement more info	PubMed
phagocytosis	TAS Traceable Author Statement more info	PubMed
positive regulation of blood pressure	IEA Inferred from Electronic Annotation more info
positive regulation of epidermal growth factor-activated receptor activity	IEA Inferred from Electronic Annotation more info
positive regulation of nucleoside transport	IEA Inferred from Electronic Annotation more info
positive regulation of peptide secretion	IEA Inferred from Electronic Annotation more info
positive regulation of potassium ion transport	IEA Inferred from Electronic Annotation more info
positive regulation of protein dephosphorylation	IEA Inferred from Electronic Annotation more info
protein targeting to membrane	IEA Inferred from Electronic Annotation more info
regulation of excitatory postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
regulation of glomerular filtration	IEA Inferred from Electronic Annotation more info
regulation of respiratory gaseous exchange by neurological system process	IEA Inferred from Electronic Annotation more info
regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
relaxation of vascular smooth muscle	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
signal transduction	TAS Traceable Author Statement more info	PubMed
temperature homeostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
asymmetric synapse	IEA Inferred from Electronic Annotation more info
axolemma	IEA Inferred from Electronic Annotation more info
basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
endomembrane system	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
neuronal cell body	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info
postsynaptic density	IEA Inferred from Electronic Annotation more info
postsynaptic membrane	IEA Inferred from Electronic Annotation more info
presynaptic active zone	IEA Inferred from Electronic Annotation more info
presynaptic membrane	IEA Inferred from Electronic Annotation more info
terminal bouton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenosine receptor A1

Names: adenosine receptor A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000674.2 → NP_000665.1 adenosine receptor A1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC105940, BU740906, DB171678, L22214

Consensus CDS

CCDS1434.1

UniProtKB/Swiss-Prot

P30542

Related

ENSP00000338435, ENST00000337894

Conserved Domains (2) summary

pfam00001
Location:32 – 288
Blast Score: 253

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:20 – 116
Blast Score: 89

7tm_4; Olfactory receptor
NM_001048230.1 → NP_001041695.1 adenosine receptor A1

Status: REVIEWED

Description

Transcript Variant: This variant (2) is missing one of the 5' non-coding exons, and thus has a shorter 5' UTR compared to transcript variant 1. Both variants encode the same protein.

Source sequence(s)

AC105940, AK127752, BU740906, DA343445

Consensus CDS

CCDS1434.1

UniProtKB/Swiss-Prot

P30542

Related

ENSP00000356205, OTTHUMP00000039090, ENST00000367236, OTTHUMT00000100273

Conserved Domains (2) summary

pfam00001
Location:32 – 288
Blast Score: 253

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:20 – 116
Blast Score: 89

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p10 Primary Assembly

Range

203096836..203136533

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

174262408..174301662

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018912.1 Alternate CHM1_1.0

Range

209633898..209673576

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01027484.1 (109707..132836)	None
genomic	ABBA01027485.1	None
genomic	AC105940.2 (32014..108764)	None
genomic	AMYH01001654.1 (75604..115282)	None
genomic	CH471067.1	EAW91465.1
genomic	GM047589.1	CAV33768.1
mRNA	AB004662.1	BAA20433.1
mRNA	AK095060.1	None
mRNA	AK127752.1	BAG54566.1
mRNA	AK289928.1	BAF82617.1
mRNA	AK295584.1	BAH12115.1
mRNA	AK308733.1	None
mRNA	AY136746.1	AAN01272.1
mRNA	BC026340.1	AAH26340.1
mRNA	BT019854.1	AAV38657.1
mRNA	BU740906.1	None
mRNA	CR541749.1	CAG46549.1
mRNA	DA343445.1	None
mRNA	DB171678.1	None
mRNA	L22214.1	AAA17544.1
mRNA	S45235.1	AAB23388.1
mRNA	S56143.1	AAB25533.2
mRNA	X68485.1	CAA48503.1
other-genetic	DQ892378.2	ABM83304.1
other-genetic	DQ892379.2	ABM83305.1
other-genetic	DQ893284.2	ABM84210.1
other-genetic	DQ895592.2	ABM86518.1
other-genetic	DQ896616.2	ABM87615.1