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    Csn3 casein kappa [ Mus musculus (house mouse) ]

    Gene ID: 12994, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Csn3provided by MGI
    Official Full Name
    casein kappaprovided by MGI
    Primary source
    MGI:MGI:107461
    See related
    Ensembl:ENSMUSG00000001622 AllianceGenome:MGI:107461
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Csnk; CSN10
    Summary
    Acts upstream of or within lactation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in central nervous system and retina. Orthologous to human CSN3 (casein kappa). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward mammary gland adult (RPKM 13.7) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 E1; 5 43.56 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (88073438..88080409)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (87925579..87932550)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene odontogenic, ameloblast asssociated Neighboring gene RIKEN cDNA 1700066N21 gene Neighboring gene cDNA sequence BC037156 Neighboring gene cDNA sequence BC051076 Neighboring gene STARR-seq mESC enhancer starr_13565 Neighboring gene calcium binding protein, spermatid specific 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of mouse mammary gland kappa-casein: comparison with rat kappa-casein and rat and human gamma-fibrinogen. Thompson MD, et al. DNA, 1985 Aug. PMID 4042811
    2. Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit 3-mediated ABCA1 stabilization in inducing foam cell formation and atherogenesis. Boro M, et al. Cell Death Differ, 2021 Feb. PMID 32968199, Free PMC Article
    3. Evidence from milk casein genes that cetaceans are close relatives of hippopotamid artiodactyls. Gatesy J, et al. Mol Biol Evol, 1996 Sep. PMID 8752004
    4. Csn3 gene is regulated by all-trans retinoic acid during neural differentiation in mouse P19 cells. Komori R, et al. PLoS One, 2013. PMID 23613978, Free PMC Article
    5. Expression analysis of the individual bovine beta-, alpha s2- and kappa-casein genes in transgenic mice. Rijnkels M, et al. Biochem J, 1995 Nov 1. PMID 7487953, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit 3-mediated ABCA1 stabilization in inducing foam cell formation and atherogenesis.
      Title: Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit 3-mediated ABCA1 stabilization in inducing foam cell formation and atherogenesis.
    2. the Csn3 expression is upregulated via all-trans retinoic acid-bound RARalpha.
      Title: Csn3 gene is regulated by all-trans retinoic acid during neural differentiation in mouse P19 cells.
    3. CSN3 and CSN5 are involved in oocyte meiosis by regulating degradation of Cyclin B1 and Securin via APC/C.
      Title: Function of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradation.
    4. kappa-casein has a role in mouse lactation
      Title: kappa-casein-deficient mice fail to lactate.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lactation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lactation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kappa-casein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356570.1 → NP_001343499.1  kappa-casein isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC022298, AK164788
      Consensus CDS
      CCDS19396.1
      UniProtKB/Swiss-Prot
      P06796, Q9D1U2
      Related
      ENSMUSP00000001667.7, ENSMUST00000001667.13
      Conserved Domains (1) summary
      pfam00997
      Location:22 → 180
      Casein_kappa; Kappa casein

    2. NM_001356571.1 → NP_001343500.1  kappa-casein isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC022298
      Conserved Domains (1) summary
      pfam00997
      Location:20 → 170
      Casein_kappa; Kappa casein

    3. NM_007786.5 → NP_031812.2  kappa-casein isoform a precursor

      See identical proteins and their annotated locations for NP_031812.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC022298, AK142673
      Consensus CDS
      CCDS19396.1
      UniProtKB/Swiss-Prot
      P06796, Q9D1U2
      Related
      ENSMUSP00000108896.3, ENSMUST00000113271.3
      Conserved Domains (1) summary
      pfam00997
      Location:22 → 180
      Casein_kappa; Kappa casein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      88073438..88080409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06796.2 GenPept UniProtKB/Swiss-Prot:P06796

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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