Mta1 metastasis associated 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mta1provided by MGI
Official Full Name: metastasis associated 1provided by MGI
Primary source: MGI:MGI:2150037
See related: Ensembl:ENSMUSG00000021144 AllianceGenome:MGI:2150037
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coactivator activity. Involved in several processes, including circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and locomotor rhythm. Located in cytoplasm and nucleus. Part of NuRD complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and long bone epiphysis. Orthologous to human MTA1 (metastasis associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 62.3), adrenal adult (RPKM 52.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 61.57 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (113061830..113100826)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (113098248..113137206)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MTA1, a metastasisassociated protein, in endothelial cells is an essential molecule for angiogenesis.
Title: MTA1, a metastasis‑associated protein, in endothelial cells is an essential molecule for angiogenesis.
Metastasis-associated protein 1 (MTA1) regulates the catecholamine production homeostasis via transcriptional repression of aromatic l-amino acid decarboxylase (Aadc) in the interstitial cells of Cajal of mouse prostate.
Title: Metastasis-associated protein 1 (MTA1) regulates the catecholamine production homeostasis via transcriptional repression of aromatic l-amino acid decarboxylase (Aadc) in the interstitial cells of Cajal of mouse prostate.
MTA1 participates in the formation of pulmonary capillaries via stabilization of HIF-1alpha. This finding sheds new light on the function of MTA1 in lung development.
Title: Metastasis-Associated Protein 1 Deficiency Results in Compromised Pulmonary Alveolar Capillary Angiogenesis in Mice.
Findings illustrate how cancer cells utilize a chromatin remodeling factor to engage a core survival pathway to support its cancerous phenotypes, and reveal new facets of MTA1-SGK1 axis by a physiologic signal in cancer progression.
Title: Cytoplasmic translocation of MTA1 coregulator promotes de-repression of SGK1 transcription in hypoxic cancer cells.
the augmentation of endogenous MTA1 expression during neuronal ischemic injury acts additionally to an endocrinous cascade orchestrating intimate interactions between ERalpha and BCL2 pathways.
Title: Neuroprotective effects of a chromatin modifier on ischemia/reperfusion neurons: implication of its regulation of BCL2 transactivation by ERα signaling.
Findings highlight MTA1 as a key upstream regulator of prostate tumorigenesis and cancer progression.
Title: Dietary pterostilbene is a novel MTA1-targeted chemopreventive and therapeutic agent in prostate cancer.
Inhibition of MTA1 expression by in vivo siRNA treatment exacerbated the pathology of LPS-induced acute lung injury, by selectively promoting the expression of NF-kappaB-regulated inflammatory cytokines.
Title: Repression of a chromatin modifier aggravates lipopolysaccharide-induced acute lung injury in mouse.
MTA1 was regulated by HIF-1alpha in hypoxia circumstance to suppress osteoblast differentiation.
Title: Hypoxia-induced MTA1 promotes MC3T3 osteoblast growth but suppresses MC3T3 osteoblast differentiation.
MTA1 levels were increased in monosodium urate crystal-induced inflammation.
Title: The metastatic tumor antigen 1-transglutaminase-2 pathway is involved in self-limitation of monosodium urate crystal-induced inflammation by upregulating TGF-β1.
The inhibition of MTA1 gene could depress the growth and metastasis of laryngeal squamous cell carcinoma in nude mice.
Title: [MTA1-specific shRNA inhibits the growth and metastasis of mouse xenograft of laryngeal squamous cell carcinoma].

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mta1 (e-PCR), detects polymorphism
- UniSTS:233957

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in entrainment of circadian clock by photoperiod	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell fate specification	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of stem cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in response to ionizing radiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ionizing radiation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ionizing radiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in secretory granule organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of NuRD complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuRD complex	IPI Inferred from Physical Interaction more info	PubMed
part_of NuRD complex	ISO Inferred from Sequence Orthology more info
part_of NuRD complex	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metastasis-associated protein MTA1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346696.1 → NP_001333625.1 metastasis-associated protein MTA1 isoform 2

Status: VALIDATED

Source sequence(s)

AB794096, AC073562, BU053969

Consensus CDS

CCDS84004.1

UniProtKB/TrEMBL

E9PX23, M1VB37

Related

ENSMUSP00000105349.3, ENSMUST00000109727.9
NM_001364620.1 → NP_001351549.1 metastasis-associated protein MTA1 isoform 3

Status: VALIDATED

Source sequence(s)

AB794101, AC073562

UniProtKB/TrEMBL

M1VB37, M1VMF6

Conserved Domains (4) summary

cd11661
Location:287 → 332

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:388 → 441

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 188

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:167 → 219

ELM2; ELM2 domain
NM_001364621.1 → NP_001351550.1 metastasis-associated protein MTA1 isoform 4

Status: VALIDATED

Source sequence(s)

AC073562

UniProtKB/Swiss-Prot

Q80UI1, Q8K4B0, Q8K4D4, Q924K9

UniProtKB/TrEMBL

M1VB37, M1VHG1

Related

ENSMUSP00000009099.7, ENSMUST00000009099.13

Conserved Domains (4) summary

cd11661
Location:287 → 332

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:388 → 441

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 188

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:167 → 219

ELM2; ELM2 domain
NM_001364622.1 → NP_001351551.1 metastasis-associated protein MTA1 isoform 5

Status: VALIDATED

Source sequence(s)

AC073562

UniProtKB/TrEMBL

M1VB37, M1VHG6

Conserved Domains (4) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:371 → 424

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 171

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 202

ELM2; ELM2 domain
NM_001364623.1 → NP_001351552.1 metastasis-associated protein MTA1 isoform 6

Status: VALIDATED

Source sequence(s)

AC073562

UniProtKB/TrEMBL

M1VB37, M1VHG3

Conserved Domains (4) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:371 → 424

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 171

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 202

ELM2; ELM2 domain
NM_054081.2 → NP_473422.2 metastasis-associated protein MTA1 isoform 1

See identical proteins and their annotated locations for NP_473422.2

Status: VALIDATED

Source sequence(s)

AC073562, BC112910, CF171555, CJ139622, CX203022, CX213009

Consensus CDS

CCDS36574.1

UniProtKB/TrEMBL

F8WHY8, M1VB37

Related

ENSMUSP00000105348.2, ENSMUST00000109726.8

Conserved Domains (6) summary

smart00717
Location:269 → 316

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:371 → 424

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:375 → 431

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:3 → 171

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 202

ELM2; ELM2 domain

RNA

NR_157248.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC073562
NR_157249.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC073562
NR_157250.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC073562
NR_157251.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC073562
NR_186595.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC073562

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

113061830..113100826

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515418.3 → XP_006515481.1 metastasis-associated protein MTA1 isoform X1

See identical proteins and their annotated locations for XP_006515481.1

UniProtKB/TrEMBL

M1VB37

Conserved Domains (5) summary

cd11661
Location:287 → 332

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:388 → 441

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 188

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:167 → 219

ELM2; ELM2 domain

pfam17226
Location:464 → 541

MTA_R1; MTA R1 domain
XM_006515420.3 → XP_006515483.1 metastasis-associated protein MTA1 isoform X2

See identical proteins and their annotated locations for XP_006515483.1

UniProtKB/TrEMBL

M1VB37

Conserved Domains (5) summary

cd11661
Location:287 → 332

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:388 → 441

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 188

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:167 → 219

ELM2; ELM2 domain

pfam17226
Location:464 → 541

MTA_R1; MTA R1 domain
XM_006515425.3 → XP_006515488.1 metastasis-associated protein MTA1 isoform X5

See identical proteins and their annotated locations for XP_006515488.1

UniProtKB/TrEMBL

M1VB37

Conserved Domains (5) summary

cd11661
Location:287 → 332

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:388 → 441

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 188

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:167 → 219

ELM2; ELM2 domain

pfam17226
Location:464 → 541

MTA_R1; MTA R1 domain
XM_006515421.3 → XP_006515484.1 metastasis-associated protein MTA1 isoform X3

See identical proteins and their annotated locations for XP_006515484.1

UniProtKB/TrEMBL

M1VB37

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:371 → 424

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 171

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 202

ELM2; ELM2 domain

pfam17226
Location:447 → 524

MTA_R1; MTA R1 domain
XM_036157169.1 → XP_036013062.1 metastasis-associated protein MTA1 isoform X4

UniProtKB/TrEMBL

M1VB37

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:371 → 424

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 171

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 202

ELM2; ELM2 domain

pfam17226
Location:447 → 524

MTA_R1; MTA R1 domain
XM_030246531.1 → XP_030102391.1 metastasis-associated protein MTA1 isoform X6

UniProtKB/TrEMBL

M1VB37

Conserved Domains (5) summary

cd11661
Location:196 → 241

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:297 → 350

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cl02608
Location:1 → 97

BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...

pfam01448
Location:76 → 128

ELM2; ELM2 domain

pfam17226
Location:373 → 450

MTA_R1; MTA R1 domain
XM_011243988.1 → XP_011242290.1 metastasis-associated protein MTA1 isoform X7

See identical proteins and their annotated locations for XP_011242290.1

UniProtKB/TrEMBL

M1VB37

Conserved Domains (5) summary

cd11661
Location:268 → 313

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:369 → 422

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:8 → 169

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:148 → 200

ELM2; ELM2 domain

pfam17226
Location:445 → 522

MTA_R1; MTA R1 domain