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CTRC chymotrypsin C (caldecrin) [ Homo sapiens (human) ]

Gene ID: 11330, updated on 12-Apr-2015
Official Symbol
CTRCprovided by HGNC
Official Full Name
chymotrypsin C (caldecrin)provided by HGNC
Primary source
HGNC:HGNC:2523
See related
Ensembl:ENSG00000162438; HPRD:03242; MIM:601405; Vega:OTTHUMG00000002255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLCR; ELA4
Summary
This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Orthologs
See CTRC in MapViewer
Location:
1p36.21
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (15438442..15449247)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (15764938..15773153)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene forkhead-associated (FHA) phosphopeptide binding domain 1 Neighboring gene uncharacterized LOC101927417 Neighboring gene uncharacterized LOC101927441 Neighboring gene EF-hand domain family, member D2 Neighboring gene uncharacterized LOC105376767 Neighboring gene chymotrypsin-like elastase family, member 2A Neighboring gene chymotrypsin-like elastase family, member 2B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptidase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
chymotrypsin-C
Names
chymotrypsin-C
caldecrin
elastase 4
elastase IV
serum calcium decreasing factor
NP_009203.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009253.1 RefSeqGene

    Range
    5001..13216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007272.2NP_009203.2  chymotrypsin-C preproprotein

    See identical proteins and their annotated locations for NP_009203.2

    Status: REVIEWED

    Source sequence(s)
    BC015118, S82198
    Consensus CDS
    CCDS156.1
    UniProtKB/Swiss-Prot
    Q99895
    Related
    ENSP00000365116, OTTHUMP00000002321, ENST00000375949, OTTHUMT00000006435
    Conserved Domains (2) summary
    smart00020
    Location:29262
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:30265
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    15438442..15449247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540550.1XP_011538852.1  

    Conserved Domains (2) summary
    smart00020
    Location:29163
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:30173
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    15563607..15571831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)