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    DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 [ Homo sapiens (human) ]

    Gene ID: 11218, updated on 9-Jun-2013
    Official Symbol
    DDX20provided by HGNC
    Official Full Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 20provided by HGNC
    Primary source
    HGNC:2743
    See related
    Ensembl:ENSG00000064703; HPRD:05859; MIM:606168; Vega:OTTHUMG00000011956
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DP103; GEMIN3
    Summary
    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008]
    Location :
    1p21.1-p13.2
    Sequence :
    Chromosome: 1; NC_000001.10 (112298190..112310199)
    See DDX20 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene RAP1A, member of RAS oncogene family Neighboring gene keratin 18 pseudogene Neighboring gene uncharacterized LOC100506343 Neighboring gene family with sequence similarity 212, member B Neighboring gene potassium voltage-gated channel, Shal-related subfamily, member 3 Neighboring gene uncharacterized LOC643355

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Protein Gene Interaction Pubs
    Vpr, p15 vpr HIV-1 Vpr is identified to have a physical interaction with DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 (DDX20) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    Q9UHI6 Q9UKV8 AGO2    HPRD  PubMed  
    Q9UHI6 Q08211 DHX9    HPRD  PubMed  
    Q9UHI6 P41162 ETV3    HPRD  PubMed  
    Q9UHI6 O14893 GEMIN2    HPRD  PubMed  
    Q9UHI6 P57678 GEMIN4    HPRD  PubMed  
    Q9UHI6 Q8TEQ6 GEMIN5    HPRD  PubMed  
    Q9UHI6 Q92769 HDAC2    HPRD  PubMed  
    Q9UHI6 Q9UQL6 HDAC5    HPRD  PubMed  
    Q9UHI6 O75376 NCOR1    HPRD  PubMed  
    Q9UHI6 Q9Y618 NCOR2    HPRD  PubMed  
    Q9UHI6 Q15466 NR0B2    HPRD  PubMed  
    Q9UHI6 P48634 PRRC2A    HPRD  PubMed  
    Q9UHI6 Q96ST3 SIN3A    HPRD  PubMed  
    Q9UHI6 Q16637 SMN2    HPRD  PubMed  
    Q9UHI6 Survival of motor neuron 2, centromeric SMN2    HPRD  PubMed  
    Q9UHI6 P14678 SNRPB    HPRD  PubMed  
    Q9UHI6 P62314 SNRPD1    HPRD  PubMed  
    Q9UHI6 P62316 SNRPD2    HPRD  PubMed  
    Q9UHI6 P62318 SNRPD3    HPRD  PubMed  
    Q9UHI6 P62304 SNRPE    HPRD  PubMed  
    Q9UHI6 P62306 SNRPF    HPRD  PubMed  
    Q9UHI6 P62308 SNRPG    HPRD  PubMed  
    Q9UHI6 Q15833 STXBP2    HPRD  PubMed  
    Q9UHI6 O00186 STXBP3    HPRD  PubMed  
    BioGRID:116387 BioGRID:118041 AGO2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116387 BioGRID:106848 APP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116387 BioGRID:107056 BARD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:107612 CLN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:107709 COPA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116387 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:108025 DHX9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116387 BioGRID:108399 FBL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116387 BioGRID:119949 GAR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116387 BioGRID:114059 GEMIN2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116387 BioGRID:119102 GEMIN4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116387 BioGRID:117429 GEMIN5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116387 BioGRID:122925 GEMIN6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116387 BioGRID:117520 GIGYF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:109187 GSK3B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:121778 LSM2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116387 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:116459 PHB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:116440 PNKP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:122173 POLR1E    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:127414 PPP4R2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116387 BioGRID:113646 PRRC2A    BioGRID  PubMed Two-hybrid 
    BioGRID:116387 BioGRID:125912 RN7SK    BioGRID  PubMed Protein-RNA 
    BioGRID:116387 BioGRID:116125 RNPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:117920 RNU1-1    BioGRID  PubMed Protein-RNA 
    BioGRID:116387 BioGRID:111993 RNU2-1    BioGRID  PubMed Protein-RNA 
    BioGRID:116387 BioGRID:119602 SIRT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:122479 SLX1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:112490 SMN1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex 
    BioGRID:116387 BioGRID:112491 SMN2    BioGRID  PubMed Co-fractionation 
    BioGRID:116387 BioGRID:112512 SNRPB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116387 BioGRID:112516 SNRPD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116387 BioGRID:112517 SNRPD2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116387 BioGRID:112518 SNRPD3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116387 BioGRID:112519 SNRPE    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116387 BioGRID:112520 SNRPF    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116387 BioGRID:112521 SNRPG    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116387 BioGRID:115384 SNUPN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116387 BioGRID:112607 SRP54    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116387 BioGRID:112604 SRP9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116387 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:112791 TCF3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:115791 UBD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:113885 UBL4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116387 BioGRID:1205540 vpr    BioGRID  PubMed Affinity Capture-MS 
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Metabolism of non-coding RNA, organism-specific biosystem (from REACTOME)
      Metabolism of non-coding RNA, organism-specific biosystemThe term non-coding is commonly employed for RNA that does not encode a protein, but this does not mean that such RNAs do not contain information nor have function. There is considerable evidence tha...
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Survival motor neuron (SMN) complex, organism-specific biosystem (from KEGG)
      Survival motor neuron (SMN) complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
    • snRNP Assembly, organism-specific biosystem (from REACTOME)
      snRNP Assembly, organism-specific biosystemSmall nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA...

    Markers

    Homology

    Clone Names

    • DKFZp434H052

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent RNA helicase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA metabolic process TAS
    Traceable Author Statement
    more info
     
    RNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    assembly of spliceosomal tri-snRNP TAS
    Traceable Author Statement
    more info
    PubMed 
    gene expression TAS
    Traceable Author Statement
    more info
     
    induction of apoptosis IEA
    Inferred from Electronic Annotation
    more info
     
    ncRNA metabolic process TAS
    Traceable Author Statement
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spliceosomal snRNP assembly TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Cajal body IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional repressor complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    probable ATP-dependent RNA helicase DDX20
    Names
    probable ATP-dependent RNA helicase DDX20
    gemin-3
    DEAD box protein 20
    component of gems 3
    DEAD-box protein DP103
    DEAD box protein DP 103
    SMN-interacting protein
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD
    NP_009135.4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007204.4NP_009135.4  probable ATP-dependent RNA helicase DDX20

      Status: REVIEWED

      Source sequence(s)
      AF171063, AK001506, AL049557, AY007146, DB072947
      Consensus CDS
      CCDS842.1
      UniProtKB/TrEMBL
      Q9H4N4
      UniProtKB/Swiss-Prot
      Q9UHI6
      Related
      ENSP00000358716, OTTHUMP00000013738, ENST00000369702, OTTHUMT00000033063
      Conserved Domains (3) summary
      cd00268
      Location:64265
      Blast Score: 513
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      cd00079
      Location:291412
      Blast Score: 203
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      smart00487
      Location:77279
      Blast Score: 353
      DEXDc; DEAD-like helicases superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p10 Primary Assembly

      Range
      112298190..112310199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      110169580..110181600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018912.1 Alternate CHM1_1.0

      Range
      112370860..112382870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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