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    Slc25a45 solute carrier family 25, member 45 [ Mus musculus (house mouse) ]

    Gene ID: 107375, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Slc25a45provided by MGI
    Official Full Name
    solute carrier family 25, member 45provided by MGI
    Primary source
    MGI:MGI:2147731
    See related
    Ensembl:ENSMUSG00000024818 AllianceGenome:MGI:2147731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable acyl carnitine transmembrane transporter activity. Predicted to be involved in acyl carnitine transport and amino acid transport. Located in mitochondrion. Is expressed in several structures, including alimentary system; hemolymphoid system; liver; and urinary system. Orthologous to human SLC25A45 (solute carrier family 25 member 45). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum adult (RPKM 85.7), small intestine adult (RPKM 41.3) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc25a45 in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5927828..5935796)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5877801..5885768)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene nuclear paraspeckle assembly transcript 1 (non-protein coding) Neighboring gene STARR-seq mESC enhancer starr_45410 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5844330-5844513 Neighboring gene STARR-seq mESC enhancer starr_45411 Neighboring gene FERM domain containing 8, opposite strand Neighboring gene FERM domain containing 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5878208-5878317 Neighboring gene STARR-positive B cell enhancer ABC_E1522 Neighboring gene tigger transposable element derived 3 Neighboring gene double PHD fingers 2 Neighboring gene STARR-positive B cell enhancer ABC_E7628

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 25 member 45

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361973.1 → NP_001348902.1  solute carrier family 25 member 45 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC142098
      Consensus CDS
      CCDS29482.1
      UniProtKB/Swiss-Prot
      Q3TC75, Q3UZE9, Q8CFJ7, Q8VBZ7
      Related
      ENSMUSP00000121596.2, ENSMUST00000155697.8
      Conserved Domains (1) summary
      pfam00153
      Location:197 → 288
      Mito_carr; Mitochondrial carrier protein

    2. NM_001361974.1 → NP_001348903.1  solute carrier family 25 member 45 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC142098
      Consensus CDS
      CCDS89319.1
      UniProtKB/TrEMBL
      A0A494BAQ4, D3Z5G2
      Related
      ENSMUSP00000117220.2, ENSMUST00000145200.8
      Conserved Domains (1) summary
      pfam00153
      Location:139 → 230
      Mito_carr; Mitochondrial carrier protein

    3. NM_001425851.1 → NP_001412780.1  solute carrier family 25 member 45 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC142098
      UniProtKB/TrEMBL
      A0A494BAQ4

    4. NM_134154.4 → NP_598915.1  solute carrier family 25 member 45 isoform 1

      See identical proteins and their annotated locations for NP_598915.1

      Status: VALIDATED

      Source sequence(s)
      AC142098
      Consensus CDS
      CCDS29482.1
      UniProtKB/Swiss-Prot
      Q3TC75, Q3UZE9, Q8CFJ7, Q8VBZ7
      Related
      ENSMUSP00000025732.8, ENSMUST00000025732.14
      Conserved Domains (1) summary
      pfam00153
      Location:197 → 288
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5927828..5935796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161393.1 → XP_036017286.1  solute carrier family 25 member 45 isoform X1

      UniProtKB/TrEMBL
      A0A494BAQ4, D3Z5G2
      Conserved Domains (1) summary
      pfam00153
      Location:139 → 230
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CFJ7.1 GenPept UniProtKB/Swiss-Prot:Q8CFJ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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