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    NOG noggin [ Canis lupus familiaris (dog) ]

    Gene ID: 100683515, updated on 8-Mar-2024

    Summary

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    Official Symbol
    NOGprovided by VGNC
    Official Full Name
    nogginprovided by VGNC
    Primary source
    VGNC:VGNC:55663
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 9
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (32262855..32263712)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (30695378..30696228)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (31415982..31416833)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (31048413..31049269)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (31332204..31333060)

    Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and fibronectin type III domain containing 1 Neighboring gene cytochrome c oxidase subunit 6A1, mitochondrial-like Neighboring gene uncharacterized LOC119873302 Neighboring gene chromosome 9 C17orf67 homolog Neighboring gene diacylglycerol kinase epsilon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A defect in the NOG gene increases susceptibility to spontaneous superficial chronic corneal epithelial defects (SCCED) in boxer dogs. Meurs KM, et al. BMC Vet Res, 2021 Jul 26. PMID 34311726, Free PMC Article
    2. Novel protective and risk loci in hip dysplasia in German Shepherds. Mikkola LI, et al. PLoS Genet, 2019 Jul. PMID 31323019, Free PMC Article
    3. Nucleotide polymorphisms in the canine Noggin gene and their distribution among dog (Canis lupus familiaris) breeds. Ishii Y, et al. Biochem Genet, 2012 Feb. PMID 21882044, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A defect in the NOG gene increases susceptibility to spontaneous superficial chronic corneal epithelial defects (SCCED) in boxer dogs.
      Title: A defect in the NOG gene increases susceptibility to spontaneous superficial chronic corneal epithelial defects (SCCED) in boxer dogs.
    2. Study have discovered novel variants of a putative NOG enhancer to be associated with healthy and mildly dysplastic hip joints in German Shepherds. in vitro expression data suggests that the variant upstream of NOG has potential gene-regulatory consequences. It is possible that the regulation of noggin expression levels is suboptimal in hip joints of German Shepherds prone to develop moderate-to-severe hip dysplasia.
      Title: Novel protective and risk loci in hip dysplasia in German Shepherds.
    3. polymorphisms in the canine Noggin gene and their distribution among dog breeds
      Title: Nucleotide polymorphisms in the canine Noggin gene and their distribution among dog (Canis lupus familiaris) breeds.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in dorsal/ventral pattern formation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    noggin; LOW QUALITY PROTEIN: noggin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051813.1 Reference ROS_Cfam_1.0

      Range
      32262855..32263712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038675217.1 → XP_038531145.1  LOW QUALITY PROTEIN: noggin

      UniProtKB/TrEMBL
      A0A8C0LJQ4, A0A8C0N257, E2RVU1, E2RVU3
      Conserved Domains (1) summary
      pfam05806
      Location:12 → 240
      Noggin

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049269.1 Alternate UMICH_Zoey_3.1

      Range
      31048413..31049269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038487625.1 → XP_038343553.1  noggin

      Conserved Domains (1) summary
      pfam05806
      Location:12 → 238
      Noggin

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

      Range
      31332204..31333060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038610151.1 → XP_038466079.1  noggin

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

      Range
      31415982..31416833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038546146.1 → XP_038402074.1  noggin

      UniProtKB/TrEMBL
      A0A8C0N257, A0A8C0U0I1, E2RVU0, E2RVU3
      Conserved Domains (1) summary
      pfam05806
      Location:12 → 238
      Noggin

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      30695378..30696228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005624988.2 → XP_005625045.2  noggin

      UniProtKB/TrEMBL
      A0A8C0N257, A0A8C0U0I1, E2RVU0, E2RVU3
      Conserved Domains (1) summary
      pfam05806
      Location:12 → 238
      Noggin
    Nucleotide Protein
    Heading Accession and Version

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