Card11 caspase recruitment domain family, member 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Card11provided by RGD
Official Full Name: caspase recruitment domain family, member 11provided by RGD
Primary source: RGD:2323211
See related: Ensembl:ENSRNOG00000024277 AllianceGenome:RGD:2323211
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable CARD domain binding activity and protein self-association. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of NF-kappaB transcription factor activity; and positive regulation of T cell receptor signaling pathway. Predicted to act upstream of or within several processes, including lymphocyte differentiation; positive regulation of interleukin-2 production; and regulation of lymphocyte activation. Predicted to be located in cytoplasm; immunological synapse; and membrane raft. Predicted to be part of CBM complex. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma; immunodeficiency 11A; and immunodeficiency 11B. Orthologous to human CARD11 (caspase recruitment domain family member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 141.6), Thymus (RPKM 53.8) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (18735088..18872045)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (13621140..13758115)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (15700600..15844512)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH139757 (e-PCR)
- UniSTS:221841

D12Wox5 (e-PCR)
- UniSTS:119250

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CARD domain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of B cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within B cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell costimulation	ISO Inferred from Sequence Orthology more info
involved_in TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lymphocyte activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thymic T cell selection	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CBM complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caspase recruitment domain-containing protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419863.1 → NP_001406792.1 caspase recruitment domain-containing protein 11

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A8I5ZNJ6

Related

ENSRNOP00000079664.1, ENSRNOT00000092970.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

18735088..18872045

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089959.2 → XP_038945887.1 caspase recruitment domain-containing protein 11 isoform X1

UniProtKB/TrEMBL

A0A8I5ZNJ6, A0A8I6AA96

Conserved Domains (4) summary

COG1196
Location:127 → 435

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:680 → 752

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd08808
Location:22 → 107

CARD_CARD11_CARMA1; Caspase activation and recruitment domain of CARD11-like proteins

cl17036
Location:777 → 839

SH3; Src Homology 3 domain superfamily