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    TDRD15 tudor domain containing 15 [ Homo sapiens (human) ]

    Gene ID: 100129278, updated on 8-Mar-2024

    Summary

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    Official Symbol
    TDRD15provided by HGNC
    Official Full Name
    tudor domain containing 15provided by HGNC
    Primary source
    HGNC:HGNC:45037
    See related
    Ensembl:ENSG00000218819 AllianceGenome:HGNC:45037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Restricted expression toward testis (RPKM 3.5) See more
    Orthologs
    all
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    Genomic context

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    See TDRD15 in Genome Data Viewer
    Location:
    2p24.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (21123932..21147325)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (21157138..21180528)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (21346840..21367240)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene APOB 3' scaffold/matrix attachment region Neighboring gene apolipoprotein B Neighboring gene APOB 5' regulatory region Neighboring gene Sharpr-MPRA regulatory region 5245 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:21290821-21291609 Neighboring gene uncharacterized LOC124905593 Neighboring gene uncharacterized LOC124908055 Neighboring gene APOB intestinal control region Neighboring gene Sharpr-MPRA regulatory region 2464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:21436748-21437248 Neighboring gene uncharacterized LOC105374317 Neighboring gene MPRA-validated peak3614 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr2:21488316-21488485 Neighboring gene uncharacterized LOC105374318

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LDL-cholesterol concentrations: a genome-wide association study. Sandhu MS, et al. Lancet, 2008 Feb 9. PMID 18262040, Free PMC Article
    2. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Hu Q, et al. Cell Res, 2019 Apr. PMID 30631154, Free PMC Article
    3. Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB. Li FL, et al. EMBO J, 2022 Sep 1. PMID 35844135, Free PMC Article
    4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. Drissi R, et al. Mol Cell Proteomics, 2015 Jul. PMID 25963833, Free PMC Article
    5. Panorama of ancient metazoan macromolecular complexes. Wan C, et al. Nature, 2015 Sep 17. PMID 26344197, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    tudor domain-containing protein 15
    Names
    tudor domain-containing protein 6-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306137.2 → NP_001293066.1  tudor domain-containing protein 15

      See identical proteins and their annotated locations for NP_001293066.1

      Status: VALIDATED

      Source sequence(s)
      AC010872
      Consensus CDS
      CCDS77385.1
      UniProtKB/Swiss-Prot
      B5MCY1
      Related
      ENSP00000384376.2, ENST00000405799.3
      Conserved Domains (2) summary
      cd04508
      Location:1346 → 1393
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:479 → 600
      TUDOR; Tudor domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      21123932..21147325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533212.2 → XP_011531514.1  tudor domain-containing protein 15 isoform X1

      See identical proteins and their annotated locations for XP_011531514.1

      UniProtKB/Swiss-Prot
      B5MCY1
      Conserved Domains (2) summary
      cd04508
      Location:1346 → 1393
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:479 → 600
      TUDOR; Tudor domain

    RNA

    1. XR_939798.3 RNA Sequence

    2. XR_001738578.2 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791767.1 Reference GRCh38.p14 PATCHES

      Range
      174600..197993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333002.1 → XP_054188977.1  tudor domain-containing protein 15 isoform X1

      UniProtKB/Swiss-Prot
      B5MCY1

    RNA

    1. XR_008485814.1 RNA Sequence

    2. XR_008485813.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      21157138..21180528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340046.1 → XP_054196021.1  tudor domain-containing protein 15 isoform X1

    RNA

    1. XR_008486237.1 RNA Sequence

    2. XR_008486236.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5MCY1.1 GenPept UniProtKB/Swiss-Prot:B5MCY1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials