CENPA centromere protein A [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: CENPAprovided by CGNC
Official Full Name: centromere protein Aprovided by CGNC
Primary source: CGNC:59248
See related: Ensembl:ENSGALG00010003178
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: CENP-A; ggCENP-A
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	16	NC_052547.1 (2245147..2246867)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	16	NC_052588.1 (1146277..1147996)

Chromosome 16 - NC_052547.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of karyology data confirmed that the location of the main CENP-A peaks in chromosomes is the best means of locating the centromeres in 25 galGal5 chromosome models, the majority of which (16) are fully sequenced and assembled.
Title: But where did the centromeres go in the chicken genome models?
M18BP1/KNL2 is essential for centromere formation through direct binding to CENP-A nucleosome in non-mammalian vertebrates.
Title: Association of M18BP1/KNL2 with CENP-A Nucleosome Is Essential for Centromere Formation in Non-mammalian Vertebrates.
CCAN has two distinct roles: recruiting CENP-A to establish the kinetochore and serving as a structural core to directly recruit kinetochore proteins.
Title: The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly.
CENP-H-containing complex facilitates deposition of newly synthesized CENP-A into centromeric chromatin in cooperation with FACT and CHD1.
Title: CENP-H-containing complex facilitates centromere deposition of CENP-A in cooperation with FACT and CHD1.
Data show that CENP-A induces some positioning of its own and some unwrapping at the entry-exit relative to canonical nucleosomes on both 5 S DNA and the alpha-satellite sequence on which it is normally loaded.
Title: CENP-A-containing nucleosomes: easier disassembly versus exclusive centromeric localization.
CENP-A-depleted cells exhibit a specific defect in maintaining kinetochore localization of the checkpoint protein BubR1 under conditions of checkpoint activation
Title: CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of nucleosome	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: histone H3-like centromeric protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001101037.3 → NP_001094507.1 histone H3-like centromeric protein A

See identical proteins and their annotated locations for NP_001094507.1

Status: VALIDATED

Source sequence(s)

JAENSK010000283

UniProtKB/Swiss-Prot

Q6XXM1

UniProtKB/TrEMBL

A5HUM4

Related

ENSGALP00010004431.1, ENSGALT00010007407.1

Conserved Domains (2) summary

pfam00125
Location:35 → 124

Histone; Core histone H2A/H2B/H3/H4

cl23735
Location:35 → 128

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...