Format

Send to:

Choose Destination
    • Showing Current items.

    Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [ Mus musculus (house mouse) ]

    Gene ID: 18033, updated on 26-Jul-2016
    Official Symbol
    Nfkb1provided by MGI
    Official Full Name
    nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105provided by MGI
    Primary source
    MGI:MGI:97312
    See related
    Ensembl:ENSMUSG00000028163 Vega:OTTMUSG00000016668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p50; p105; NF-KB1; p50/p105; NF-kappaB; NF-kappaB1
    Orthologs
    Location:
    3 G3; 3 62.82 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (135584655..135691982, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (135247619..135354511, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30992 Neighboring gene ornithine decarboxylase antizyme 2 pseudogene Neighboring gene mannosidase, beta A, lysosomal Neighboring gene uncharacterized LOC108168903 Neighboring gene RIKEN cDNA 4933401H06 gene Neighboring gene solute carrier family 39 (metal ion transporter), member 8 Neighboring gene predicted gene, 31243 Neighboring gene transmembrane protein 126A pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RNA polymerase II distal enhancer sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    I-kappaB kinase/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NIK/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to brain-derived neurotrophic factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to carbohydrate stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to diterpene ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to glucoside ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interleukin-6 ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to peptide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to peptide hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lymph node development TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of calcidiol 1-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-12 biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hyaluronan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pri-miRNA transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to cytokine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to muscle stretch IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    I-kappaB/NF-kappaB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    nuclear factor NF-kappa-B p105 subunit
    Names
    DNA-binding factor KBF1
    EBP-1
    NF kappaB1
    NF-kappa-B1 p84/NF-kappa-B1 p98
    NF-kappaB p50
    nuclear factor kappaB p50
    nuclear factor of kappa light chain gene enhancer in B-cells 1, p105
    nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
    nuclear factor-kappaB p50
    p50 subunit of NF kappaB
    p50 subunit of NF-kappaB

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008689.2NP_032715.2  nuclear factor NF-kappa-B p105 subunit

      See identical proteins and their annotated locations for NP_032715.2

      Status: VALIDATED

      Source sequence(s)
      AB221614, AK159423, AW907469, BC050841
      Consensus CDS
      CCDS17858.1
      UniProtKB/Swiss-Prot
      P25799
      Related
      ENSMUSP00000029812, OTTMUSP00000018024, ENSMUST00000029812, OTTMUST00000040338
      Conserved Domains (6) summary
      cd07935
      Location:40241
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      cd00204
      Location:572701
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:248349
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      pfam12796
      Location:582676
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:666722
      Ank_5; Ankyrin repeats (many copies)
      cd08797
      Location:812886
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      135584655..135691982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501106.2XP_006501169.1  

      UniProtKB/Swiss-Prot
      P25799
      Conserved Domains (6) summary
      cd07935
      Location:40241
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      cd00204
      Location:572701
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:248349
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      pfam12796
      Location:582676
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:666722
      Ank_5; Ankyrin repeats (many copies)
      cl14633
      Location:812865
      DD; Death Domain Superfamily of protein-protein interaction domains
    2. XM_006501107.1XP_006501170.1  

      Conserved Domains (6) summary
      cd00204
      Location:443572
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:119220
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      pfam12796
      Location:453547
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:537593
      Ank_5; Ankyrin repeats (many copies)
      cd08797
      Location:683757
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      cl08275
      Location:1112
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)