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    CSF2 colony stimulating factor 2 [ Bos taurus (cattle) ]

    Gene ID: 281095, updated on 26-May-2016
    Gene symbol
    CSF2
    Gene description
    colony stimulating factor 2
    See related
    BGD:BT18522; Ensembl:ENSBTAG00000001570
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CSF; GMCSF; GM-CSF
    Orthologs
    Location:
    chromosome: 7
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    105 current Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 7 AC_000164.1 (23694183..23696548, complement)

    Chromosome 7 - AC_000164.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S4, X-linked X-like pseudogene Neighboring gene uncharacterized LOC104969122 Neighboring gene interleukin 3 (colony-stimulating factor, multiple) Neighboring gene acyl-CoA synthetase long-chain family member 6

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    granulocyte macrophage colony-stimulating factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    embryonic placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    interferon-tau production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    myeloid dendritic cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cytolysis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-23 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of macrophage derived foam cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of podosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of trophectodermal cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of tyrosine phosphorylation of Stat5 protein IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    granulocyte-macrophage colony-stimulating factor
    Names
    colony stimulating factor 2 (granulocyte-macrophage)
    colony-stimulating factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174027.2NP_776452.1  granulocyte-macrophage colony-stimulating factor precursor

      See identical proteins and their annotated locations for NP_776452.1

      Status: PROVISIONAL

      Source sequence(s)
      U22385
      UniProtKB/Swiss-Prot
      P11052
      Related
      ENSBTAP00000002054, ENSBTAT00000002054
      Conserved Domains (1) summary
      cd00040
      Location:18137
      CSF2; Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine ...

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Bos_taurus_UMD_3.1.1 Primary Assembly

    Genomic

    1. AC_000164.1 Reference Bos_taurus_UMD_3.1.1 Primary Assembly

      Range
      23694183..23696548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Btau_5.0.1

    Genomic

    1. NC_007305.6 Alternate Btau_5.0.1

      Range
      23777230..23779595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)