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    Cd6 CD6 antigen [ Mus musculus (house mouse) ]

    Gene ID: 12511, updated on 21-Nov-2015
    Official Symbol
    Cd6provided by MGI
    Official Full Name
    CD6 antigenprovided by MGI
    Primary source
    MGI:MGI:103566
    See related
    Ensembl:ENSMUSG00000024670 Vega:OTTMUSG00000036965
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    Location:
    19 A; 19 7.16 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (10789339..10830059, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (10863829..10904548, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene CD5 antigen Neighboring gene RIKEN cDNA A430093F15 gene Neighboring gene solute carrier family 15, member 3 Neighboring gene transmembrane protein 132A Neighboring gene transmembrane protein 109

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    glycoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipoteichoic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acute inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    immunological synapse formation ISO
    Inferred from Sequence Orthology
    more info
     
    lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with T cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    immunological synapse ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    spanning component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    T-cell differentiation antigen CD6

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037801.2NP_001032890.1  T-cell differentiation antigen CD6 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001032890.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an in-frame segment in the coding region, compared to variant 2. The resulting protein (isoform 1) is shorter when it is compared to isoform 2.
      Source sequence(s)
      AK030823, BQ553341
      Consensus CDS
      CCDS50391.1
      UniProtKB/Swiss-Prot
      Q61003
      Related
      ENSMUSP00000046861, OTTMUSP00000052979, ENSMUST00000039043, OTTMUST00000095004
      Conserved Domains (1) summary
      smart00202
      Location:160259
      SR; Scavenger receptor Cys-rich
    2. NM_009852.3NP_033982.3  T-cell differentiation antigen CD6 isoform 2 precursor

      See identical proteins and their annotated locations for NP_033982.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer protein (isoform 2).
      Source sequence(s)
      AK030823, BQ553341
      Consensus CDS
      CCDS37917.1
      UniProtKB/Swiss-Prot
      Q61003
      Related
      ENSMUSP00000079172, OTTMUSP00000052978, ENSMUST00000080292, OTTMUST00000095000
      Conserved Domains (1) summary
      smart00202
      Location:160259
      SR; Scavenger receptor Cys-rich

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

      Range
      10789339..10830059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526622.1XP_006526685.1  

      Conserved Domains (1) summary
      smart00202
      Location:160259
      SR; Scavenger receptor Cys-rich

    Alternate Mm_Celera

    Genomic

    1. AC_000041.1 Alternate Mm_Celera

      Range
      11482305..11523180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)