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Cd44 CD44 antigen [ Mus musculus (house mouse) ]

Gene ID: 12505, updated on 23-Sep-2014
Official Symbol
Cd44provided by MGI
Official Full Name
CD44 antigenprovided by MGI
Primary source
MGI:MGI:88338
Locus tag
RP23-203N8.3
See related
Ensembl:ENSMUSG00000005087; Vega:OTTMUSG00000014837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly-24; Pgp-1; HERMES; AU023126; AW121933; AW146109
See Cd44 in Epigenomics, MapViewer
Location:
2 E2; 2 54.13 cM
Exon count:
20
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 2 NC_000068.7 (102811141..102901673, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene peptidase domain containing associated with muscle regeneration 1 Neighboring gene solute carrier family 1 (glial high affinity glutamate transporter), member 2 Neighboring gene uncharacterized LOC102637542 Neighboring gene uncharacterized LOC102637680 Neighboring gene uncharacterized LOC102637752

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to cytokine binding IDA
Inferred from Direct Assay
more info
PubMed 
epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
hyaluronic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
hyaluronic acid binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
hyaluronic acid binding ISO
Inferred from Sequence Orthology
more info
 
hyalurononglucosaminidase activity ISO
Inferred from Sequence Orthology
more info
 
phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
branching involved in prostate gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion ISO
Inferred from Sequence Orthology
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
hyaluronan catabolic process ISO
Inferred from Sequence Orthology
more info
 
macrophage fusion ISO
Inferred from Sequence Orthology
more info
 
monocyte aggregation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mature B cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of adaptive immune response NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of monocyte aggregation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neutrophil apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
wound healing involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
CD44 antigen
Names
CD44 antigen
PGP-I
HUTCH-I
ECMR-III
hermes antigen
hyaluronate receptor
lymphocyte antigen 24
phagocytic glycoprotein 1
phagocytic glycoprotein I
extracellular matrix receptor III
GP90 lymphocyte homing/adhesion receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039150.1NP_001034239.1  CD44 antigen isoform b precursor

    See proteins identical to NP_001034239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several alternate, in-frame, exons, compared to variant 1. The resulting protein (isoform b) is shorter when it is compared to isoform a.
    Source sequence(s)
    AL844155, CT010324
    Consensus CDS
    CCDS16470.1
    UniProtKB/TrEMBL
    Q80X37
    Conserved Domains (1) summary
    cd03516
    Location:30173
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  2. NM_001039151.1NP_001034240.1  CD44 antigen isoform c precursor

    See proteins identical to NP_001034240.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several alternate, in-frame, exons, compared to variant 1. The resulting protein (isoform c) is shorter when it is compared to isoform a.
    Source sequence(s)
    AK045226, AL844155
    Consensus CDS
    CCDS16471.1
    UniProtKB/Swiss-Prot
    P15379
    UniProtKB/TrEMBL
    Q3U8S1
    Conserved Domains (1) summary
    cd03516
    Location:30173
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  3. NM_001177785.1NP_001171256.1  CD44 antigen isoform d precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several alternate, in-frame, exons, compared to variant 1. The resulting protein (isoform d) is shorter when it is compared to isoform a.
    Source sequence(s)
    AJ251594, AK045226, AL844155
    Consensus CDS
    CCDS50650.1
    UniProtKB/TrEMBL
    A2APM1
    UniProtKB/Swiss-Prot
    P15379
    Related
    ENSMUSP00000106825, ENSMUST00000111194
    Conserved Domains (1) summary
    cd03516
    Location:30173
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  4. NM_001177786.1NP_001171257.1  CD44 antigen isoform e precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks several alternate, in-frame, exons, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a.
    Source sequence(s)
    AJ251594, AK045226, AL844155
    Consensus CDS
    CCDS50649.1
    UniProtKB/TrEMBL
    A2APM4
    UniProtKB/Swiss-Prot
    P15379
    Conserved Domains (1) summary
    cd03516
    Location:30173
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  5. NM_001177787.1NP_001171258.1  CD44 antigen isoform f precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks several alternate, in-frame, exons, compared to variant 1. The resulting protein (isoform f) is shorter when it is compared to isoform a.
    Source sequence(s)
    AJ251594, AK045226, AL844155
    Consensus CDS
    CCDS50648.1
    UniProtKB/TrEMBL
    A2APM3
    UniProtKB/Swiss-Prot
    P15379
    Conserved Domains (1) summary
    cd03516
    Location:30173
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  6. NM_009851.2NP_033981.2  CD44 antigen isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a).
    Source sequence(s)
    AJ251594, AK045226, AL844155
    Consensus CDS
    CCDS16472.1
    UniProtKB/TrEMBL
    A2APM2
    UniProtKB/Swiss-Prot
    P15379
    Related
    ENSMUSP00000005218, OTTMUSP00000015733, ENSMUST00000005218, OTTMUST00000035222
    Conserved Domains (1) summary
    cd03516
    Location:30173
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000068.7 

    Range
    102811141..102901673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498645.1XP_006498708.1  

    Conserved Domains (1) summary
    cd03516
    Location:30173
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  2. XM_006498646.1XP_006498709.1  

    Conserved Domains (1) summary
    cd03516
    Location:30173
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  3. XM_006498647.1XP_006498710.1  

    Conserved Domains (1) summary
    cd03516
    Location:30173
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  4. XM_006498649.1XP_006498712.1  

    Conserved Domains (1) summary
    cd03516
    Location:30173
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  5. XM_006498648.1XP_006498711.1  

    Conserved Domains (1) summary
    cd03516
    Location:30173
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

Alternate Mm_Celera

Genomic

  1. AC_000024.1 

    Range
    104054974..104145651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)