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Abcd2 ATP-binding cassette, subfamily D (ALD), member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84356, updated on 19-Jul-2014
Official Symbol
Abcd2provided by RGD
Official Full Name
ATP-binding cassette, subfamily D (ALD), member 2provided by RGD
Primary source
RGD:69244
See related
Ensembl:ENSRNOG00000015538
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
ALDR
Summary
ATP-binding cassette (ABC) peroxisomal half-transporter that assembles with ALDRP to form a functional heterodimer; mutation in ABCD proteins causes X-linked adrenoleukodystrophy [RGD, Feb 2006]
See Abcd2 in MapViewer
Location:
7q35
Exon count:
10
Annotation release Status Assembly Chr Location
104 current Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (131968475..132017044, complement)

Chromosome 7 - NC_005106.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550888 Neighboring gene similar to Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Presenilin-stabilization factor) Neighboring gene kinesin family member 21A Neighboring gene hypothetical protein LOC690142 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 13

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • ABC transporters, organism-specific biosystem (from KEGG)
    ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC transporters, conserved biosystem (from KEGG)
    ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem (from WikiPathways)
    Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystemNuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. Ho...
  • Peroxisome, organism-specific biosystem (from KEGG)
    Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Peroxisome, conserved biosystem (from KEGG)
    Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity, coupled to transmembrane movement of substances IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
ATP catabolic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
very long-chain fatty acid catabolic process IEA
Inferred from Electronic Annotation
more info
 
very long-chain fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
very long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome IEA
Inferred from Electronic Annotation
more info
 
peroxisome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
ATP-binding cassette sub-family D member 2
Names
ATP-binding cassette sub-family D member 2
adrenoleukodystrophy-related protein
ATP-binding cassette, sub-family D (ALD), member 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033352.1NP_203503.1  ATP-binding cassette sub-family D member 2

    See proteins identical to NP_203503.1

    Status: PROVISIONAL

    Source sequence(s)
    AF131294
    UniProtKB/Swiss-Prot
    Q9QY44
    Related
    ENSRNOP00000021064, ENSRNOT00000021064
    Conserved Domains (3) summary
    cd03223
    Location:479684
    Blast Score: 661
    ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
    TIGR00954
    Location:74686
    Blast Score: 2135
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protei
    pfam06472
    Location:78365
    Blast Score: 1003
    ABC_membrane_2; ABC transporter transmembrane region 2

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

  1. NC_005106.3 

    Range
    131968475..132017044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000075.1 

    Range
    118713620..118762172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)