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CORO1A coronin, actin binding protein, 1A [ Homo sapiens (human) ]

Gene ID: 11151, updated on 25-Jan-2015
Official Symbol
CORO1Aprovided by HGNC
Official Full Name
coronin, actin binding protein, 1Aprovided by HGNC
Primary source
HGNC:HGNC:2252
See related
Ensembl:ENSG00000102879; HPRD:05414; MIM:605000; Vega:OTTHUMG00000132148
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p57; IMD8; TACO; CLABP; HCORO1; CLIPINA
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
Orthologs
See CORO1A in MapViewer
Location:
16p11.2
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 16 NC_000016.10 (30183410..30189076)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30194731..30200397)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928595 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3 Neighboring gene mitogen-activated protein kinase 3 Neighboring gene SLX1A-SULT1A3 readthrough (NMD candidate) Neighboring gene bolA family member 2B Neighboring gene SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) Neighboring gene sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 Neighboring gene coiled-coil domain containing 101 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ41407, MGC117380

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeletal protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol 3-kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament organization IEA
Inferred from Electronic Annotation
more info
 
calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
 
early endosome to recycling endosome transport IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
innate immune response NAS
Non-traceable Author Statement
more info
PubMed 
leukocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
movement of cell or subcellular component NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of vesicle fusion IEA
Inferred from Electronic Annotation
more info
 
nerve growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagolysosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
uropod organization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
actin filament IDA
Inferred from Direct Assay
more info
PubMed 
axon IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
early endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
immunological synapse IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleus IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic cup IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
coronin-1A
Names
coronin-1A
clipin-A
coronin-1
coronin-like protein A
coronin-like protein p57
tryptophan aspartate-containing coat protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023415.1 

    Range
    4806..10472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_195

mRNA and Protein(s)

  1. NM_001193333.2NP_001180262.1  coronin-1A

    See proteins identical to NP_001180262.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK314714, BC110374, DA256300, DC408372, U34690
    Consensus CDS
    CCDS10673.1
    UniProtKB/TrEMBL
    A0A024R611
    UniProtKB/Swiss-Prot
    P31146
    Related
    ENSP00000455552, OTTHUMP00000255254, ENST00000570045, OTTHUMT00000434064
    Conserved Domains (5) summary
    pfam08953
    Location:468
    DUF1899; Domain of unknown function (DUF1899)
    PTZ00421
    Location:9461
    PTZ00421; coronin; Provisional
    cd00200
    Location:76302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08954
    Location:258392
    DUF1900; Domain of unknown function (DUF1900)
    cl01209
    Location:378455
    DUF480; Protein of unknown function, DUF480
  2. NM_007074.3NP_009005.1  coronin-1A

    See proteins identical to NP_009005.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC110374, DA256300, DC408372, U34690
    Consensus CDS
    CCDS10673.1
    UniProtKB/TrEMBL
    A0A024R611
    UniProtKB/Swiss-Prot
    P31146
    Related
    ENSP00000219150, OTTHUMP00000163017, ENST00000219150, OTTHUMT00000255195
    Conserved Domains (5) summary
    pfam08953
    Location:468
    DUF1899; Domain of unknown function (DUF1899)
    PTZ00421
    Location:9461
    PTZ00421; coronin; Provisional
    cd00200
    Location:76302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08954
    Location:258392
    DUF1900; Domain of unknown function (DUF1900)
    cl01209
    Location:378455
    DUF480; Protein of unknown function, DUF480

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 

    Range
    30183410..30189076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 

    Range
    31409355..31415021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000148.1 

    Range
    27857375..27863041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)