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    CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 [ Homo sapiens (human) ]

    Gene ID: 1555, updated on 26-Jul-2015
    Official Symbol
    CYP2B6provided by HGNC
    Official Full Name
    cytochrome P450, family 2, subfamily B, polypeptide 6provided by HGNC
    Primary source
    HGNC:HGNC:2615
    See related
    Ensembl:ENSG00000197408; HPRD:00477; MIM:123930; Vega:OTTHUMG00000182714
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPB6; EFVM; IIB1; P450; CYP2B; CYP2B7; CYP2B7P; CYPIIB6
    Summary
    This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
    Orthologs
    See CYP2B6 in Epigenomics, MapViewer
    Location:
    19q13.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (40991229..41018398)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41497138..41524308)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily G, polypeptide 1 pseudogene Neighboring gene cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene Neighboring gene cytochrome P450, family 2, subfamily A, polypeptide 7 pseudogene 1 Neighboring gene cytochrome P450, family 2, subfamily G, polypeptide 2 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Efavirenz response
    MedGen: C3281153 OMIM: 614546 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of cytochrome p450 family proteins CYP2E1, CYP2D6, and CYP2B6 in astrocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    arachidonic acid epoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    heme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    oxygen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    steroid hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    cellular ketone metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epoxygenase P450 pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    exogenous drug catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    steroid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    cytochrome P450 2B6
    Names
    1,4-cineole 2-exo-monooxygenase
    cytochrome P450 IIB1
    cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
    NP_000758.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007929.1 RefSeqGene

      Range
      5001..32098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000767.4NP_000758.1  cytochrome P450 2B6 precursor

      See identical proteins and their annotated locations for NP_000758.1

      Status: REVIEWED

      Source sequence(s)
      M29874
      Consensus CDS
      CCDS12570.1
      UniProtKB/Swiss-Prot
      P20813
      Related
      ENSP00000324648, OTTHUMP00000269953, ENST00000324071, OTTHUMT00000463260
      Conserved Domains (1) summary
      pfam00067
      Location:42488
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

      Range
      40991229..41018398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526546.1XP_011524848.1  

      Conserved Domains (1) summary
      pfam00067
      Location:42384
      p450; Cytochrome P450
    2. XM_006723050.2XP_006723113.1  

      Conserved Domains (1) summary
      pfam00067
      Location:42432
      p450; Cytochrome P450
    3. XM_011526547.1XP_011524849.1  

      Conserved Domains (1) summary
      pfam00067
      Location:42384
      p450; Cytochrome P450
    4. XM_005258569.3XP_005258626.1  

      Conserved Domains (1) summary
      pfam00067
      Location:42386
      p450; Cytochrome P450
    5. XM_011526548.1XP_011524850.1  

      Conserved Domains (1) summary
      pfam00067
      Location:42328
      p450; Cytochrome P450
    6. XM_011526550.1XP_011524852.1  

      See identical proteins and their annotated locations for XP_011524852.1

      UniProtKB/Swiss-Prot
      P20813
      Conserved Domains (1) summary
      pfam00067
      Location:16288
      p450; Cytochrome P450
    7. XM_011526549.1XP_011524851.1  

      Conserved Domains (1) summary
      pfam00067
      Location:1291
      p450; Cytochrome P450

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      41496934..41524020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)