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    BATF basic leucine zipper ATF-like transcription factor [ Homo sapiens (human) ]

    Gene ID: 10538, updated on 5-Mar-2024

    Summary

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    Official Symbol
    BATFprovided by HGNC
    Official Full Name
    basic leucine zipper ATF-like transcription factorprovided by HGNC
    Primary source
    HGNC:HGNC:958
    See related
    Ensembl:ENSG00000156127 MIM:612476; AllianceGenome:HGNC:958
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SFA2; B-ATF; BATF1; SFA-2
    Summary
    The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lymph node (RPKM 11.0), appendix (RPKM 9.8) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BATF in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (75522469..75546992)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (69731553..69756105)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75988812..76013335)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8746 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75894221-75894778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5947 Neighboring gene JDP2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75904146-75904649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75905657-75906159 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75907363-75908346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75918700-75919214 Neighboring gene Jun dimerization protein 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75919215-75919730 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75919731-75920244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75925593-75926141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75941017-75941518 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75946817-75947707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75980965-75981530 Neighboring gene uncharacterized LOC105370572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8753 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:76004983-76005197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8755 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8757 Neighboring gene uncharacterized LOC107984653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5949 Neighboring gene FLVCR2 antisense RNA 1 Neighboring gene FLVCR choline and putative heme transporter 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. BATF reprograms the tumor immune status. Fan T, et al. Med, 2023 Jan 13. PMID 36640752
    2. BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors. Itahashi K, et al. Sci Immunol, 2022 Oct 14. PMID 36206353
    3. Increased BATF expression is associated with the severity of liver damage in patients with chronic hepatitis B. Wang LY, et al. Clin Exp Med, 2018 May. PMID 29164410
    4. Epstein-Barr virus nuclear antigen 3A partially coincides with EBNA3C genome-wide and is tethered to DNA through BATF complexes. Schmidt SC, et al. Proc Natl Acad Sci U S A, 2015 Jan 13. PMID 25540416, Free PMC Article
    5. Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation. Deppmann CD, et al. Biochem J, 2003 Sep 1. PMID 12809553, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells.
      Title: Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells.
    2. Relative Expression of BATF and CD112 in PBMC of Patients with Chronic Lymphocytic Leukemia.
      Title: Relative Expression of BATF and CD112 in PBMC of Patients with Chronic Lymphocytic Leukemia.
    3. BATF reprograms the tumor immune status.
      Title: BATF reprograms the tumor immune status.
    4. Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells.
      Title: Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells.
    5. BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors.
      Title: BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors.
    6. A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation.
      Title: A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation.
    7. Supervised machine learning algorithm identified KRT20, BATF and TP63 as biologically relevant biomarkers for bladder biopsy specimens from interstitial cystitis/bladder pain syndrome patients.
      Title: Supervised machine learning algorithm identified KRT20, BATF and TP63 as biologically relevant biomarkers for bladder biopsy specimens from interstitial cystitis/bladder pain syndrome patients.
    8. Prognostic Value of DNA Methylation-Driven Genes in Clear Cell Renal Cell Carcinoma: A Study Based on Methylation and Transcriptome Analyses.
      Title: Prognostic Value of DNA Methylation-Driven Genes in Clear Cell Renal Cell Carcinoma: A Study Based on Methylation and Transcriptome Analyses.
    9. results reveal that JunB, c-Jun, and Bach2 cooperate with BATF to contribute to the specificity of BATF-dependent cytokine induction in Th subsets.
      Title: BATF-Interacting Proteins Dictate Specificity in Th Subset Activity.
    10. BATF-dependent pathogenic GM-CSF+ effector T cells are critical promoters of intestinal inflammation in graft-versus-host disease
      Title: BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA damage response, signal transduction by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in T-helper 17 cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in T-helper 17 cell lineage commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in T-helper 2 cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in defense response to protozoan ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in hematopoietic stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in integrated stress response signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in isotype switching ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lymphoid progenitor cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in myeloid dendritic cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of T-helper 17 cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    basic leucine zipper transcriptional factor ATF-like
    Names
    B-cell-activating transcription factor
    SF-HT-activated gene 2 protein
    activating transcription factor B
    basic leucine zipper transcription factor, ATF-like

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006399.5 → NP_006390.1  basic leucine zipper transcriptional factor ATF-like

      See identical proteins and their annotated locations for NP_006390.1

      Status: REVIEWED

      Source sequence(s)
      BC032294, BP235761, U15460
      Consensus CDS
      CCDS9843.1
      UniProtKB/Swiss-Prot
      Q16520
      Related
      ENSP00000286639.6, ENST00000286639.8
      Conserved Domains (1) summary
      cd14701
      Location:26 → 83
      bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      75522469..75546992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      69731553..69756105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16520.1 GenPept UniProtKB/Swiss-Prot:Q16520

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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