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    PDE4D phosphodiesterase 4D, cAMP-specific [ Homo sapiens (human) ]

    Gene ID: 5144, updated on 24-Aug-2015
    Official Symbol
    PDE4Dprovided by HGNC
    Official Full Name
    phosphodiesterase 4D, cAMP-specificprovided by HGNC
    Primary source
    HGNC:HGNC:8783
    See related
    Ensembl:ENSG00000113448; HPRD:02530; MIM:600129; Vega:OTTHUMG00000162218
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2
    Summary
    This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
    Orthologs
    See PDE4D in Epigenomics, MapViewer
    Location:
    5q12
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (58969038..60522120, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (58264865..59783925, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RAB3C, member RAS oncogene family Neighboring gene uncharacterized LOC105378986 Neighboring gene ribosomal protein L5 pseudogene 15 Neighboring gene uncharacterized LOC105378990 Neighboring gene uncharacterized LOC105378989 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa pseudogene 2 Neighboring gene uncharacterized LOC105378988 Neighboring gene microRNA 582 Neighboring gene uncharacterized LOC105378987 Neighboring gene ribosomal protein L31 pseudogene 8 Neighboring gene SET pseudogene 21 Neighboring gene prostate androgen-regulated transcript 1 (non-protein coding) Neighboring gene DEP domain containing 1B Neighboring gene keratin 8 pseudogene 31

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Acrodysostosis 2, with or without hormone resistance
    MedGen: C3553250 OMIM: 614613 GeneReviews: Not available
    Compare labs
    Stroke 1
    MedGen: C1847482 OMIM: 606799 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated (2015-03-11)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated (2015-03-11)

    ClinGen Genome Curation Page

    NHGRI GWAS Catalog

    Description
    A whole genome association study of neuroticism using DNA pooling.
    NHGRI GWA Catalog
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    NHGRI GWA Catalog
    Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.
    NHGRI GWA Catalog
    Genome-wide association of sleep and circadian phenotypes.
    NHGRI GWA Catalog
    Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
    NHGRI GWA Catalog
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    NHGRI GWA Catalog
    Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment.
    NHGRI GWA Catalog
    Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
    NHGRI GWA Catalog
    Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Cyclic AMP phosphodiesterase inhibitors AV411 and AV1013 inhibit HIV-1 replication and block HIV-1 Tat-induced neurotoxicity in human microglia, suggesting that cyclic AMP phosphodiesterase is involved in the Tat-mediated neurotoxicity PubMed
    tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

    Go to the HIV-1, Human Interaction Database

    • DARPP-32 events, organism-specific biosystem (from REACTOME)
      DARPP-32 events, organism-specific biosystemDopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified as a major target for dopamine and protein kinase A (PKA) in striatum. Recent advances now indicate that regulation D...
    • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
      G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Morphine addiction, organism-specific biosystem (from KEGG)
      Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Morphine addiction, conserved biosystem (from KEGG)
      Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Opioid Signalling, organism-specific biosystem (from REACTOME)
      Opioid Signalling, organism-specific biosystemOpioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as...
    • Purine metabolism, organism-specific biosystem (from KEGG)
      Purine metabolism, organism-specific biosystem
      Purine metabolism
    • Purine metabolism, conserved biosystem (from KEGG)
      Purine metabolism, conserved biosystem
      Purine metabolism
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • TSH signaling pathway, organism-specific biosystem (from WikiPathways)
      TSH signaling pathway, organism-specific biosystemHuman thyroid stimulating hormone (TSH) is a glycoprotein secreted by the anterior part of the pituitary gland (1). TSH plays an important physiological role in the regulation of the hypothalamic-pit...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ97311, DKFZp686M11213

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    3',5'-cyclic-AMP phosphodiesterase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    3',5'-cyclic-nucleotide phosphodiesterase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    beta-2 adrenergic receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cAMP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    ion channel binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ion channel binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adrenergic receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    adrenergic receptor signaling pathway involved in positive regulation of heart rate IC
    Inferred by Curator
    more info
     
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    cAMP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cAMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cAMP catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cAMP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cAMP-mediated signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cellular protein complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to cAMP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to epinephrine stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to epinephrine stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of endothelial barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lung development IEA
    Inferred from Electronic Annotation
    more info
     
    memory IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of heart contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of relaxation of cardiac muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-5 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of G-protein coupled receptor protein signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cAMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cardiac muscle cell contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of cell communication by electrical coupling involved in cardiac conduction IC
    Inferred by Curator
    more info
    PubMed 
    regulation of heart rate ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of protein kinase A signaling IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of ryanodine-sensitive calcium-release channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    calcium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myofibril IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with voltage-gated calcium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    Names
    cAMP-specific phosphodiesterase PDE4D6
    phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
    NP_001098101.1
    NP_001159371.1
    NP_001184147.1
    NP_001184148.1
    NP_001184149.1
    NP_001184150.1
    NP_001184151.1
    NP_001184152.1
    NP_006194.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027957.1 RefSeqGene

      Range
      5001..1524061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104631.1NP_001098101.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D4

      See identical proteins and their annotated locations for NP_001098101.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (PDE4D4, also known as isoform 1).
      Source sequence(s)
      AC027322, AC092343, BF197530, L20969
      Consensus CDS
      CCDS47213.1
      UniProtKB/Swiss-Prot
      Q08499
      Related
      ENSP00000345502, OTTHUMP00000221595, ENST00000340635, OTTHUMT00000367940
      Conserved Domains (1) summary
      cd00077
      Location:461643
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    2. NM_001165899.1NP_001159371.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D7

      See identical proteins and their annotated locations for NP_001159371.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D7 (also known as isoform 3) has a shorter and distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, AY245866, BI492585, DB230503
      Consensus CDS
      CCDS54859.1
      UniProtKB/Swiss-Prot
      Q08499
      Conserved Domains (1) summary
      cd00077
      Location:400582
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    3. NM_001197218.1NP_001184147.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D5

      See identical proteins and their annotated locations for NP_001184147.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D5 (also known as isoform 4) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, AF012073, BF197530
      Consensus CDS
      CCDS56373.1
      UniProtKB/Swiss-Prot
      Q08499
      Conserved Domains (1) summary
      cd00077
      Location:397579
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    4. NM_001197219.1NP_001184148.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D8

      See identical proteins and their annotated locations for NP_001184148.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D8 (also known as isoform 5) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC008791, AC092343, AF012073, AF536977, BF197530
      Consensus CDS
      CCDS56372.1
      UniProtKB/Swiss-Prot
      Q08499
      Conserved Domains (1) summary
      cd00077
      Location:339521
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    5. NM_001197220.1NP_001184149.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D9

      See identical proteins and their annotated locations for NP_001184149.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D9 (also known as isoform 6) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, AF012073, AY245867, BF197530
      Consensus CDS
      CCDS56371.1
      UniProtKB/Swiss-Prot
      Q08499
      Conserved Domains (1) summary
      cd00077
      Location:331513
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    6. NM_001197221.1NP_001184150.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D2

      See identical proteins and their annotated locations for NP_001184150.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D2 (also known as isoform 7) is shorter at the N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, AF012074, BF197530
      Consensus CDS
      CCDS56370.1
      UniProtKB/Swiss-Prot
      Q08499
      Conserved Domains (1) summary
      cd00077
      Location:159341
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    7. NM_001197222.1NP_001184151.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D1

      See identical proteins and their annotated locations for NP_001184151.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D1 (also known as isoform 8) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, AF012074, BF197530, U50157
      UniProtKB/Swiss-Prot
      Q08499
      Conserved Domains (1) summary
      cd00077
      Location:237419
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    8. NM_001197223.1NP_001184152.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D6

      See identical proteins and their annotated locations for NP_001184152.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D6 (also known as isoform 9) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, AF536975, BC036319, BF197530
      Consensus CDS
      CCDS56369.1
      UniProtKB/Swiss-Prot
      Q08499
      Conserved Domains (1) summary
      cd00077
      Location:170352
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    9. NM_006203.4NP_006194.2  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D3

      See identical proteins and their annotated locations for NP_006194.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D3 (also known as isoform 2) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, BF197530, L20970, U50159
      Consensus CDS
      CCDS54858.1
      UniProtKB/Swiss-Prot
      Q08499
      Conserved Domains (1) summary
      cd00077
      Location:325507
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

      Range
      58969038..60522120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543472.1XP_011541774.1  

      See identical proteins and their annotated locations for XP_011541774.1

      UniProtKB/Swiss-Prot
      Q08499
      Conserved Domains (1) summary
      cd00077
      Location:400582
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    2. XM_011543473.1XP_011541775.1  

      See identical proteins and their annotated locations for XP_011541775.1

      UniProtKB/Swiss-Prot
      Q08499
      Conserved Domains (1) summary
      cd00077
      Location:400582
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    3. XM_011543469.1XP_011541771.1  

      See identical proteins and their annotated locations for XP_011541771.1

      Conserved Domains (1) summary
      cd00077
      Location:449631
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    4. XM_011543474.1XP_011541776.1  

      Conserved Domains (1) summary
      cd00077
      Location:390572
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    5. XM_011543471.1XP_011541773.1  

      See identical proteins and their annotated locations for XP_011541773.1

      UniProtKB/Swiss-Prot
      Q08499
      Conserved Domains (1) summary
      cd00077
      Location:400582
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    6. XM_011543470.1XP_011541772.1  

      See identical proteins and their annotated locations for XP_011541772.1

      Conserved Domains (1) summary
      cd00077
      Location:449631
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    7. XM_011543477.1XP_011541779.1  

      Conserved Domains (1) summary
      cd00077
      Location:314496
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    8. XM_005248538.3XP_005248595.1  

      See identical proteins and their annotated locations for XP_005248595.1

      UniProtKB/Swiss-Prot
      Q08499
      Conserved Domains (1) summary
      cd00077
      Location:325507
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    9. XM_011543478.1XP_011541780.1  

      See identical proteins and their annotated locations for XP_011541780.1

      Conserved Domains (1) summary
      cd00077
      Location:293475
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    10. XM_011543475.1XP_011541777.1  

      Conserved Domains (1) summary
      cd00077
      Location:339521
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    11. XM_011543476.1XP_011541778.1  

      Conserved Domains (1) summary
      cd00077
      Location:321503
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    12. XM_005248537.2XP_005248594.1  

      See identical proteins and their annotated locations for XP_005248594.1

      Conserved Domains (1) summary
      cd00077
      Location:351533
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    13. XM_011543479.1XP_011541781.1  

      See identical proteins and their annotated locations for XP_011541781.1

      Related
      ENSP00000442734, ENST00000546160
      Conserved Domains (1) summary
      cd00077
      Location:293475
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      58265111..59783530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)