OR6A2 olfactory receptor family 6 subfamily A member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OR6A2provided by HGNC
Official Full Name: olfactory receptor family 6 subfamily A member 2provided by HGNC
Primary source: HGNC:HGNC:15301
See related: Ensembl:ENSG00000184933 MIM:608495; AllianceGenome:HGNC:15301
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: I7; OR6A1; OR6A2P; OR11-55
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs: mouse all
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Genomic context

Location:: 11p15.4

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (6791736..6799689, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (6850158..6858111, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (6812967..6820920, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Odorant receptors in macrophages: potential targets for atherosclerosis.
Title: Odorant receptors in macrophages: potential targets for atherosclerosis.
Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.
Title: Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.
I7 olfactory receptor
Title: Discrimination of saturated aldehydes by the rat I7 olfactory receptor.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

OR6A2__5928 (e-PCR)
- UniSTS:463736

Olfr2 (e-PCR), detects polymorphism
- UniSTS:531362

NoName (e-PCR)
- UniSTS:485547

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables olfactory receptor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of smell	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of smell	NAS Non-traceable Author Statement more info	PubMed
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: olfactory receptor 6A2

Names: hI7 olfactory receptor; hP2 olfactory receptor; olfactory receptor 11-55; olfactory receptor 6A1; olfactory receptor OR11-83; olfactory receptor, family 6, subfamily A, member 1; olfactory receptor, family 6, subfamily A, member 2 pseudogene; seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003696.3 → NP_003687.2 olfactory receptor 6A2

See identical proteins and their annotated locations for NP_003687.2

Status: VALIDATED

Source sequence(s)

AC087280

Consensus CDS

CCDS7772.1

UniProtKB/Swiss-Prot

O95222, Q3MJC7, Q6IF35, Q9H206

UniProtKB/TrEMBL

A0A126GW91

Related

ENSP00000492990.1, ENST00000641196.1

Conserved Domains (1) summary

cd15224
Location:41 → 299

7tmA_OR6B-like; olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors