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    AGE2 GTPase-activating protein AGE2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854767, updated on 13-Apr-2024

    Summary

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    Gene symbol
    AGE2
    Gene description
    GTPase-activating protein AGE2
    Primary source
    SGD:S000001306
    Locus tag
    YIL044C
    See related
    AllianceGenome:SGD:S000001306
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SAT2
    Summary
    Enables GTPase activator activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intra-Golgi vesicle-mediated transport. Located in cytosol. Colocalizes with clathrin-coated vesicle. Orthologous to several human genes including SMAP1 (small ArfGAP 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (272950..273846, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene ubiquitin-binding SDF ubiquitin ligase complex subunit MET30 Neighboring gene putative protein phosphatase regulator PIG2 Neighboring gene cytochrome-b5 reductase Neighboring gene protein kinase PKP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activity of specific lipid-regulated ADP ribosylation factor-GTPase-activating proteins is required for Sec14p-dependent Golgi secretory function in yeast. Yanagisawa LL, et al. Mol Biol Cell, 2002 Jul. PMID 12134061, Free PMC Article
    2. The Gcs1 and Age2 ArfGAP proteins provide overlapping essential function for transport from the yeast trans-Golgi network. Poon PP, et al. J Cell Biol, 2001 Dec 24. PMID 11756474, Free PMC Article
    3. The yeast Arf GTPase-activating protein Age1 is regulated by phospholipase D for post-Golgi vesicular transport. Benjamin JJ, et al. J Biol Chem, 2011 Feb 18. PMID 21135091, Free PMC Article
    4. Four ARF GAPs in Saccharomyces cerevisiae have both overlapping and distinct functions. Zhang CJ, et al. Yeast, 2003 Mar. PMID 12627398
    5. A family of Arf effectors defined as suppressors of the loss of Arf function in the yeast Saccharomyces cerevisiae. Zhang CJ, et al. J Biol Chem, 1998 Jul 31. PMID 9677411

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AP-3 vesicle uncoating occurs after HOPS-dependent vacuole tethering.
      Title: AP-3 vesicle uncoating occurs after HOPS-dependent vacuole tethering.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    GTPase-activating protein AGE2
    NP_012220.3
    • ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      272950..273846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179394.3 → NP_012220.3  TPA: GTPase-activating protein AGE2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012220.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVN8, P40529
      UniProtKB/TrEMBL
      A0A8H4BZ67, G2WGA2, N1P263
      Conserved Domains (1) summary
      COG5347
      Location:1 → 298
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40529.1

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