Ajuba ajuba LIM protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ajubaprovided by RGD
Official Full Name: ajuba LIM proteinprovided by RGD
Primary source: RGD:620407
See related: Ensembl:ENSRNOG00000012791 AllianceGenome:RGD:620407
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Jub
Summary: Predicted to enable several functions, including actin filament binding activity; alpha-catenin binding activity; and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; regulation of cellular response to hypoxia; and regulation of gene expression. Predicted to act upstream of or within several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; negative regulation of macromolecule metabolic process; and positive regulation of intracellular signal transduction. Located in cell-cell junction. Orthologous to human AJUBA (ajuba LIM protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 158.2), Kidney (RPKM 98.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (31989796..32000042, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (28019775..28031537, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (33208210..33218456, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We propose that Ajuba is a scaffolding protein allowing GLT-1 to regulate intracellular signaling or interact with the cytoskeleton.
Title: The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba.

Submit: New GeneRIF Correction

General gene information

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Markers

d15rat85 (e-PCR)
- UniSTS:121102

RH131975 (e-PCR)
- UniSTS:215258

D15RAT6 (e-PCR)
- UniSTS:121082

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables alpha-catenin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within focal adhesion assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycerophospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated gene silencing by inhibition of translation	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated gene silencing by inhibition of translation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within miRNA-mediated post-transcriptional gene silencing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippo signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cellular biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within wound healing, spreading of epidermal cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: LIM domain-containing protein ajuba

Names: ajuba homolog; jub, ajuba homolog; protein ajuba

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053503.1 → NP_445955.1 LIM domain-containing protein ajuba

See identical proteins and their annotated locations for NP_445955.1

Status: PROVISIONAL

Source sequence(s)

BC085802

UniProtKB/Swiss-Prot

Q5U2Z2, Q99ND4

UniProtKB/TrEMBL

A6KGU9

Related

ENSRNOP00000017753.3, ENSRNOT00000017753.6

Conserved Domains (3) summary

cd09352
Location:348 → 401

LIM1_Ajuba_like; The first LIM domain of Ajuba-like proteins

cd09355
Location:413 → 465

LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins

cd09438
Location:473 → 534

LIM3_Ajuba_like; The third LIM domain of Ajuba-like proteins