ZNF394 zinc finger protein 394 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF394provided by HGNC
Official Full Name: zinc finger protein 394provided by HGNC
Primary source: HGNC:HGNC:18832
See related: Ensembl:ENSG00000160908 MIM:619300; AllianceGenome:HGNC:18832
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZSCAN46; ZKSCAN14
Summary: The protein encoded by this gene is a zinc finger protein that inhibits the transcription of mitogen-activated protein kinase signaling pathways. The encoded protein may be involved in cardiac function. [provided by RefSeq, Sep 2016]
Expression: Broad expression in bone marrow (RPKM 26.0), spleen (RPKM 6.3) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q22.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (99486519..99500281, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (100725427..100739185, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (99084142..99097904, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of ZNF394 in the cell inhibits the transcriptional activities of c-Jun and AP-1 reporters.
Title: Inhibition of transcriptional activities of AP-1 and c-Jun by a new zinc finger protein ZNF394.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 394

Names: zinc finger protein 99; zinc finger protein with KRAB and SCAN domains 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001345967.2 → NP_001332896.1 zinc finger protein 394 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC073063

Consensus CDS

CCDS87524.1

UniProtKB/Swiss-Prot

Q53GI3

Related

ENSP00000409565.2, ENST00000426306.2
NM_001345968.2 → NP_001332897.1 zinc finger protein 394 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC073063
NM_032164.4 → NP_115540.2 zinc finger protein 394 isoform 1

See identical proteins and their annotated locations for NP_115540.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

BC051847, DA962329

Consensus CDS

CCDS5666.1

UniProtKB/Swiss-Prot

A4D281, Q05DA6, Q53GI3, Q6P5X9, Q8TB27, Q9HA37, Q9UD51

Related

ENSP00000337363.6, ENST00000337673.7

Conserved Domains (6) summary

smart00431
Location:60 → 170

SCAN; leucine rich region

COG5048
Location:356 → 420

COG5048; FOG: Zn-finger [General function prediction only]

COG5189
Location:464 → 543

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:471 → 491

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:414 → 436

zf-C2H2; Zinc finger, C2H2 type

cl02581
Location:155 → 214

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box