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    ZSCAN26 zinc finger and SCAN domain containing 26 [ Homo sapiens (human) ]

    Gene ID: 7741, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZSCAN26provided by HGNC
    Official Full Name
    zinc finger and SCAN domain containing 26provided by HGNC
    Primary source
    HGNC:HGNC:12978
    See related
    Ensembl:ENSG00000197062 MIM:616474; AllianceGenome:HGNC:12978
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SREZBP; ZNF187; SRE-ZBP
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary (RPKM 10.1), endometrium (RPKM 7.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    6p22.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (28267143..28278204)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (28138885..28149946)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28234921..28245981)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc finger with KRAB and SCAN domains 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24351 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17043 Neighboring gene NFKB activating protein like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24352 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:28234963-28235527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17044 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:28249721-28249897 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:28251848-28252055 Neighboring gene piggyBac transposable element derived 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:28278749-28279250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:28279251-28279750 Neighboring gene SMIM15 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression cloning of a novel zinc finger protein that binds to the c-fos serum response element. Attar RM, et al. Mol Cell Biol, 1992 May. PMID 1569959, Free PMC Article
    2. The transcriptome of human CD34+ hematopoietic stem-progenitor cells. Kim YC, et al. Proc Natl Acad Sci U S A, 2009 May 19. PMID 19416867, Free PMC Article
    3. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Siddaway R, et al. Mol Cell Proteomics, 2022 Oct. PMID 36089195, Free PMC Article
    4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
    5. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC2815

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger and SCAN domain-containing protein 26
    Names
    zinc finger protein 187

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001023560.4 → NP_001018854.2  zinc finger and SCAN domain-containing protein 26 isoform a

      See identical proteins and their annotated locations for NP_001018854.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK095948, AL526328, BC013951
      UniProtKB/TrEMBL
      A0A024RCN4
      Related
      ENSP00000481707.1, ENST00000421553.7
      Conserved Domains (6) summary
      smart00431
      Location:52 → 158
      SCAN; leucine rich region
      COG5048
      Location:290 → 469
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:285 → 305
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:283 → 305
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:47 → 135
      SCAN; SCAN domain
      pfam13465
      Location:297 → 322
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001111039.3 → NP_001104509.1  zinc finger and SCAN domain-containing protein 26 isoform b

      See identical proteins and their annotated locations for NP_001104509.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) uses an alternate in-frame splice site in the 5' coding region, compared to variant a. It encodes isoform b, which is shorter than isoform a.
      Source sequence(s)
      AK095948, AK301081, BC013951, DA884554
      Consensus CDS
      CCDS78119.1
      UniProtKB/Swiss-Prot
      Q16670, Q5JPG4, Q7Z3Q6, Q96A17
      Related
      ENSP00000485228.1, ENST00000623276.3
      Conserved Domains (6) summary
      smart00431
      Location:52 → 157
      SCAN; leucine rich region
      COG5048
      Location:289 → 468
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:284 → 304
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282 → 304
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:47 → 135
      SCAN; SCAN domain
      pfam13465
      Location:296 → 321
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001287421.2 → NP_001274350.1  zinc finger and SCAN domain-containing protein 26 isoform c

      See identical proteins and their annotated locations for NP_001274350.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (d) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant a. Variants c and d encode the same isoform (c), which is shorter than isoform a.
      Source sequence(s)
      AK301081, AL021997, AL832741, DA341149
      Consensus CDS
      CCDS75414.1
      UniProtKB/TrEMBL
      A0A087X2F1
      Related
      ENSP00000479314.1, ENST00000614088.1
      Conserved Domains (3) summary
      COG5048
      Location:174 → 334
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:150 → 170
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:162 → 187
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001287422.2 → NP_001274351.1  zinc finger and SCAN domain-containing protein 26 isoform d

      See identical proteins and their annotated locations for NP_001274351.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (e) lacks two exons in the 5' coding region and initiates translation at a downstream start codon, compared to variant a. It encodes isoform d, which is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK095948, AL832741, DA528922
      Consensus CDS
      CCDS75415.1
      UniProtKB/TrEMBL
      B4DMT1
      Related
      ENSP00000478769.1, ENST00000611552.2
      Conserved Domains (3) summary
      COG5048
      Location:100 → 260
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:76 → 96
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:88 → 113
      zf-H2C2_2; Zinc-finger double domain

    5. NM_152736.6 → NP_689949.3  zinc finger and SCAN domain-containing protein 26 isoform c

      See identical proteins and their annotated locations for NP_689949.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) uses an alternate in-frame splice site in the 5' coding region, compared to variant a. Variants c and d encode the same isoform (c), which is shorter than isoform a.
      Source sequence(s)
      BC013951, DB262147
      Consensus CDS
      CCDS75414.1
      UniProtKB/TrEMBL
      A0A087X2F1
      Related
      ENSP00000484931.1, ENST00000316606.10
      Conserved Domains (3) summary
      COG5048
      Location:174 → 334
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:150 → 170
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:162 → 187
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      28267143..28278204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419314.1 → XP_047275270.1  zinc finger and SCAN domain-containing protein 26 isoform X5

    2. XM_011514862.3 → XP_011513164.1  zinc finger and SCAN domain-containing protein 26 isoform X1

      See identical proteins and their annotated locations for XP_011513164.1

      UniProtKB/TrEMBL
      A0A024RCN4
      Related
      ENSP00000484018.1, ENST00000619937.4
      Conserved Domains (6) summary
      smart00431
      Location:52 → 158
      SCAN; leucine rich region
      COG5048
      Location:290 → 469
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:285 → 305
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:283 → 305
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:47 → 135
      SCAN; SCAN domain
      pfam13465
      Location:297 → 322
      zf-H2C2_2; Zinc-finger double domain

    3. XM_017011264.2 → XP_016866753.1  zinc finger and SCAN domain-containing protein 26 isoform X2

      UniProtKB/Swiss-Prot
      Q16670, Q5JPG4, Q7Z3Q6, Q96A17
      Conserved Domains (6) summary
      smart00431
      Location:52 → 157
      SCAN; leucine rich region
      COG5048
      Location:289 → 468
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:284 → 304
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282 → 304
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:47 → 135
      SCAN; SCAN domain
      pfam13465
      Location:296 → 321
      zf-H2C2_2; Zinc-finger double domain

    4. XM_011514864.2 → XP_011513166.1  zinc finger and SCAN domain-containing protein 26 isoform X3

      See identical proteins and their annotated locations for XP_011513166.1

      Conserved Domains (3) summary
      COG5048
      Location:261 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:256 → 276
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:23 → 129
      SCAN; SCAN oligomerization domain

    5. XM_047419312.1 → XP_047275268.1  zinc finger and SCAN domain-containing protein 26 isoform X4

    6. XM_047419313.1 → XP_047275269.1  zinc finger and SCAN domain-containing protein 26 isoform X5

    7. XM_024446538.2 → XP_024302306.1  zinc finger and SCAN domain-containing protein 26 isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:261 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:256 → 276
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:23 → 129
      SCAN; SCAN oligomerization domain

    8. XM_047419311.1 → XP_047275267.1  zinc finger and SCAN domain-containing protein 26 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      28138885..28149946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356349.1 → XP_054212324.1  zinc finger and SCAN domain-containing protein 26 isoform X5

    2. XM_054356342.1 → XP_054212317.1  zinc finger and SCAN domain-containing protein 26 isoform X1

      UniProtKB/TrEMBL
      A0A024RCN4

    3. XM_054356343.1 → XP_054212318.1  zinc finger and SCAN domain-containing protein 26 isoform X2

      UniProtKB/Swiss-Prot
      Q16670, Q5JPG4, Q7Z3Q6, Q96A17

    4. XM_054356345.1 → XP_054212320.1  zinc finger and SCAN domain-containing protein 26 isoform X3

    5. XM_054356347.1 → XP_054212322.1  zinc finger and SCAN domain-containing protein 26 isoform X4

    6. XM_054356348.1 → XP_054212323.1  zinc finger and SCAN domain-containing protein 26 isoform X5

    7. XM_054356344.1 → XP_054212319.1  zinc finger and SCAN domain-containing protein 26 isoform X3

    8. XM_054356346.1 → XP_054212321.1  zinc finger and SCAN domain-containing protein 26 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_007151.1: Suppressed sequence

      Description
      NM_007151.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate when translated from the upstream AUG.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16670.2 GenPept UniProtKB/Swiss-Prot:Q16670

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